(2E)-3-{3-[(5-Ethyl-3-iodo-6-methyl-2-oxo-1,2-dihydropyridin-4-YL)oxy]phenyl}acrylonitrile

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2E)-3-{3-[(5-Ethyl-3-iodo-6-methyl-2-oxo-1,2-dihydropyridin-4-YL)oxy]phenyl}acrylonitrile
• 英文别名: (E)-3-[3-[(3-ethyl-5-iodo-2-methyl-6-oxo-1H-pyridin-4-yl)oxy]phenyl]prop-2-enenitrile
• 化学式: C₁₇H₁₅IN₂O₂
• 分子量: 406.22
• InChiKey: XMFUXIRAVPMVRS-FNORWQNLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  62.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• CATECHOL DIETHERS AS POTENT ANTI-HIV AGENTS
  申请人：YALE UNIVERSITY

  公开号：US20140288017A1

  公开（公告）日：2014-09-25

  The present invention is directed to novel catechol diether compounds, pharmaceutical compositions therefrom and methods for inhibiting reverse transcriptase and treating HIV infections, especially included drug resistant strains of HIV 1 and 2 and/or secondary disease states and/or conditions which occur as a consequence of HIV infection.

  本发明涉及新型儿茶酚二醚化合物、其制药组合物以及抑制反转录酶和治疗HIV感染的方法，特别包括抗药性HIV 1和2以及/或作为HIV感染后果的二级疾病状态和/或条件。
• US9487476B2
  申请人：——

  公开号：US9487476B2

  公开（公告）日：2016-11-08
• [EN] CATECHOL DIETHERS AS POTENT ANTI-HIV AGENTS<br/>[FR] DIÉTHERS DE CATÉCHOL COMME AGENTS ANTI-HIV PUISSANTS
  申请人：UNIV YALE

  公开号：WO2013056003A2

  公开（公告）日：2013-04-18

  The present invention is directed to novel catechol diether compounds, pharmaceutical compositions therefrom and methods for inhibiting reverse transcriptase and treating HIV infections, especially included drug resistant strains of HIV 1 and 2 and/or secondary disease states and/or conditions which occur as a consequence of HIV infection.