Umbelliferose

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Umbelliferose
• 英文别名: (2R,3R,4S,5R,6R)-2-[(2R,3R,4S,5R,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
• 化学式: C₁₈H₃₂O₁₆
• 分子量: 504.4
• InChiKey: LNRUEZIDUKQGRH-YZUCMPLFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.3
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  269
• 氢给体数：
  11
• 氢受体数：
  16

文献信息

• LIPID MEMBRANE STRUCTURE FOR siRNA INTRACELLULAR DELIVERY
  申请人：NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

  公开号：US20170273905A1

  公开（公告）日：2017-09-28

  A lipid membrane structure encapsulating an siRNA inside thereof and containing a lipid compound of the formula (I) as a lipid component (R 1 and R 2 represent CH 3 —(CH 2 ) n —CH═CH—CH 2 —CH═CH—(CH 2 ) m —, n represents an integer of 3 to 5, m represents an integer of 6 to 10, p represents an integer of 2 to 7, and R 3 and R 4 represent a C 1-4 alkyl group or a C 2-4 alkenyl group.

  一种脂质膜结构，其中包含一种siRNA并含有一种化合物(I)作为脂质成分（其中R1和R2代表CH3-（CH2）n-CH═CH-CH2-CH═CH-（CH2）m-，n表示3至5的整数，m表示6至10的整数，p表示2至7的整数，R3和R4代表C1-4烷基或C2-4烯基）。
• LIPID MEMBRANE STRUCTURE
  申请人：Harashima Hideyoshi

  公开号：US20130195962A1

  公开（公告）日：2013-08-01

  A lipid membrane structure for delivering a substance to a target cell having satisfactory cell permeability, selectivity for target cell, and in vivo stability, wherein lipid membrane is modified with (a) a polyalkylene glycol bound with a target cell-selective ligand; and (b) a polypeptide comprising a plurality of arginine residues.

  一种脂质膜结构，用于将物质传递到目标细胞，具有令人满意的细胞渗透性、目标细胞选择性和体内稳定性，其中脂质膜被修饰为：(a)与目标细胞选择性配体结合的聚烷基乙二醇;和(b)包含多个精氨酸残基的多肽。
• Lipid membrane structure for intracellular delivery of siRNA
  申请人：NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

  公开号：US10182987B2

  公开（公告）日：2019-01-22

  A lipid membrane structure encapsulating an siRNA inside thereof and containing a lipid compound of the formula (I) as a lipid component (R1 and R2 represent CH3—(CH2)n—CH═CH—CH2—CH═CH—(CH2)m—, n represents an integer of 3 to 5, m represents an integer of 6 to 10, p represents an integer of 2 to 7, and R3 and R4 represent a C1-4 alkyl group or a C2-4 alkenyl group.

  一种脂质膜结构，在其内部封装 siRNA，并含有式 (I) 的脂质化合物作为脂质成分（R1 和 R2 代表 CH3-(CH2)n-CH═CH-CH2-CH═CH-(CH2)m-，n 代表 3 至 5 的整数，m 代表 6 至 10 的整数，p 代表 2 至 7 的整数，R3 和 R4 代表 C1-4 烷基或 C2-4 烯基）。
• LIPID MEMBRANE STRUCTURE HAVING INTRANUCLEAR MIGRATING PROPERTY
  申请人：Harashima Hideyoshi

  公开号：US20130122054A1

  公开（公告）日：2013-05-16

  A lipid membrane structure for delivering a substance into a nucleus of a cell, wherein lipid membrane is modified with (a) a polypeptide comprising the amino acid sequence of SEQ ID NO: 1, and/or (b) a polypeptide consisting of an amino acid sequence comprising the amino acid sequence of SEQ ID NO: 1, but including deletion and/or substitution and/or insertion of one or several amino acid residues, and having an activity of promoting migration of the lipid membrane structure into a nucleus of a cell, which can efficiently deliver a nucleic acid into a nucleus of an immunocyte such as dendritic cell.
• US8981044B2
  申请人：——

  公开号：US8981044B2

  公开（公告）日：2015-03-17