Solatriose

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Solatriose
• 英文别名: (2S,3R,4R,5R,6S)-2-[(3R,4S,5S,6R)-2,5-dihydroxy-6-(hydroxymethyl)-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol
• 化学式: C₁₈H₃₂O₁₅
• 分子量: 488.4
• InChiKey: XNBZPOHDTUWNMW-QVCHUJKCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.3
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  248
• 氢给体数：
  10
• 氢受体数：
  15

文献信息

• Further syntheses of cyproterone acetate
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP1359154A1

  公开（公告）日：2003-11-05

  The present invention relates to improved methods for synthesising cyproterone acetate (17α-Acetoxy-6-chloro-1α, 2α-methylene-4,6-pregnadiene-3,20-dione) from solasodine. The methods of the invention are shorter as those of the prior art and therefore more economic.

  本发明涉及从索拉索丁合成环丙孕酮醋酸酯（17α-乙酰氧基-6-氯-1α，2α-亚甲基-4,6-孕二烯-3,20-二酮）的改进方法。本发明的方法比先前技术更短，因此更经济。
• AhR mediators
  申请人：Krutmann Jean

  公开号：US20090028804A1

  公开（公告）日：2009-01-29

  The invention relates to a method for finding and assessing agonists [and] antagonists of the aryl hydrocarbon receptor (Ah receptor; AhR), to the agonists and antagonists themselves and to uses thereof.

  这项发明涉及一种用于寻找和评估芳香族羟基化合物受体（Ah受体；AhR）的激动剂和拮抗剂的方法，以及这些激动剂和拮抗剂本身及其用途。
• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• Method for the separation of triglycoalkaloids
  申请人：SOLBEC PHARMACEUTICALS LTD.

  公开号：US20040030109A1

  公开（公告）日：2004-02-12

  In accordance with the present invention there is provided a method for the separation of a triglycoalkaloid in which the triglycoside portion comprises &agr;-L-rhamnopyranosyl-(1→2gal)-O-&bgr;-D-glucopyranosyl-(1→3gal)-&bgr;-D-galactopyranose (or 6-deoxy-&agr;-L-mannopyranosyl-(1→2)-O-[&bgr;-D-glucopyranosyl-(1→3)]-&bgr;-D-galactopyranoside) (‘an rhamnose-glucose-galactose triglycoalkaloid’) from a triglycoalkaloid in which the triglycoside portion is &agr;-L-rhamnopyranosyl-(1→2glu)-O-&agr;-L-rhamnopyranosyl-(1→4glu)-&bgr;-D-glucopyranose (‘a rhamnose-rhamnose-glucose triglycoalkaloid’) in a mixture containing both, the method comprising the steps of: Combining the mixture with a portion of alcoholic solvent; Causing or allowing a substantial portion of the rhamnose-rhamnose-glucose triglycoalkaloid to dissolve, thereby generating an alcoholic solution substantially of the rhamnose-rhamnose-glucose triglycoalkaloid, and a solid substantially comprising the rhamnose-glucose-galactose triglycoalkaloid; and Separating the solid substantially comprising the rhamnose-glucose-galactose triglycoalkaloid from the solution substantially of the rhamnose-rhamnose-glucose triglycoalkaloid.

  根据本发明提供了一种用于分离三糖生物碱的方法，其中三糖苷部分包括α-L-鼠李糖苷-(1→2半乳糖)-O-β-D-葡萄糖苷-(1→3半乳糖)-β-D-半乳糖（或6-去氧-α-L-甘露糖苷-(1→2)-O-[β-D-葡萄糖苷-(1→3)]-β-D-半乳糖苷）（称为“鼠李糖-葡萄糖-半乳糖三糖生物碱”），从其中三糖苷部分为α-L-鼠李糖苷-(1→2葡)-O-α-L-鼠李糖苷-(1→4葡)-β-D-葡萄糖苷（称为“鼠李糖-鼠李糖-葡萄糖三糖生物碱”）的混合物中分离出来，该方法包括以下步骤：将混合物与部分醇溶剂混合；导致或允许大部分鼠李糖-鼠李糖-葡萄糖三糖生物碱溶解，从而生成基本上由鼠李糖-鼠李糖-葡萄糖三糖生物碱组成的醇溶液，以及基本上由鼠李糖-葡萄糖-半乳糖三糖生物碱组成的固体；分离基本上由鼠李糖-葡萄糖-半乳糖三糖生物碱组成的固体与基本上由鼠李糖-鼠李糖-葡萄糖三糖生物碱组成的溶液。
• [EN] METHOD FOR THE SEPARATION OF TRIGLYCOALKALOIDS<br/>[FR] PROCEDE DE SEPARATION DE TRIGLYCOALCALOÏDES
  申请人：SOLBEC PHARMACEUTICALS LTD

  公开号：WO2004002998A1

  公开（公告）日：2004-01-08

  In accordance with the present invention there is provided a method for the separation of a triglycoalkaloid in which the triglycoside portion comprises α-L-rhamnopyranosyl-(1→2gal)-O-β-D-glucopyranosyl-(1→3gal)-ß-D-galactopyranose (or 6-deoxy-a-L-mannopyranosyl-(1→2)-O-[ß-D-glucopyranosyl-(1→3)]-ß-D-galactopyranoside) ('an rhamnose-glucose-galactose triglycoalkaloid') from a triglycoalkaloid in which the triglycoside portion is a-L-rhamnopyranosyl-(1→2glu)-O-a-L-rhamnopyranosyl-(1→4glu)-ß-D-glucopyranose ('a rhamnose-rhamnose-glucose triglycoalkaloid') in a mixture containing both, the method comprising the steps of: Combining the mixture with a portion of alcoholic solvent; Causing or allowing a substantial portion of the rhamnose-rhamnose-glucose triglycoalkaloid to dissolve, thereby generating an alcoholic solution substantially of the rhamnose-rhamnose-glucose triglycoalkaloid , and a solid substantially comprising the rhamnose-glucose-galactose triglycoalkaloid; and Separating the solid substantially comprising the rhamnose-glucose-galactose triglycoalkaloid from the solution substantially of the rhamnose-rhamnose-glucose triglycoalkaloid.

  根据本发明提供了一种用于从含有α-L-鼠李糖苷-(1→2半乳糖)-O-β-D-葡萄糖苷-(1→3半乳糖)-ß-D-半乳糖苷（或6-去氧-α-L-甘露糖苷-(1→2)-O-[ß-D-葡萄糖苷-(1→3)]-ß-D-半乳糖苷）（'一种鼠李糖-葡萄糖-半乳糖三糖生物碱'）中分离三糖生物碱的方法，其中三糖苷部分是α-L-鼠李糖苷-(1→2葡)-O-α-L-鼠李糖苷-(1→4葡)-ß-D-葡萄糖苷（'一种鼠李糖-鼠李糖-葡萄糖三糖生物碱'）的混合物，该方法包括以下步骤：将混合物与部分酒精溶剂结合；导致或允许大部分鼠李糖-鼠李糖-葡萄糖三糖生物碱溶解，从而生成基本上由鼠李糖-鼠李糖-葡萄糖三糖生物碱的酒精溶液，以及基本上由鼠李糖-葡萄糖-半乳糖三糖生物碱组成的固体；并将基本上由鼠李糖-葡萄糖-半乳糖三糖生物碱组成的固体与基本上由鼠李糖-鼠李糖-葡萄糖三糖生物碱的溶液分离。