1,3,5-三(3-甲氧基丙基)-1,3,5-三嗪烷 | 3960-05-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪烷类
• 中文名称: 1,3,5-三(3-甲氧基丙基)-1,3,5-三嗪烷
• 英文名称: 1,3,5-tris(3-methoxypropyl)[1,3,5]triazinane
• 英文别名: Hexahydro-1,3,5-tris(3-methoxypropyl)-s-triazine；1,3,5-tris(3-methoxypropyl)-1,3,5-triazinane
• CAS: 3960-05-2
• 化学式: C₁₅H₃₃N₃O₃
• 分子量: 303.445
• InChiKey: BYWNSSMFBBZKMO-UHFFFAOYSA-N

物化性质

• 沸点：
  370.3±42.0 °C(Predicted)
• 密度：
  0.977±0.06 g/cm3(Predicted)
• 物理描述：
  Liquid

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  21
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-{4-[2-(4-fluorophenyl)-2-hydroxyliminoacetyl]pyridin-2-yl}acetamide 、 1,3,5-三(3-甲氧基丙基)-1,3,5-三嗪烷 以 乙醇 为溶剂， 反应 6.0h， 以71%的产率得到N-{4-[5-(4-fluorophenyl)-1-oxy-3-(3-methoxypropyl)-3H-imidazol-4-yl]pyridin-2-yl}acetamide
  参考文献：
  名称：

  Tetrasubstituted Imidazole Inhibitors of Cytokine Release:  Probing Substituents in the N-1 Position

  摘要：

  We prepared novel 1,2,4,5-tetrasubstituted imidazole derivatives with high anti-inflammatory activity by using our previously described regiospecific synthesis. Systematic optimization of the imidazole N-1 substituent resulted in compound 9b that potently inhibited the mitogen-activated protein kinase p38 (p38 IC50 = 0.218 muM) as well as the release of the proinflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor alpha. (TNFalpha) from human whole blood after stimulation with LPS. Furthermore, compound 9b exhibited reduced cytochrome P450 interaction in comparison with SB203580. This result is particularly important, since cytochrome P450 interaction is observed for some p38 inhibitors and in turn can potentially cause drug-drug interaction or lead to other hepatic changes such as P450 enzyme induction.

  DOI：

  10.1021/jm0496584

文献信息

• HEXAHYDROTRIAZINES, SYNTHESIS AND USE
  申请人：Kaplan Gregory

  公开号：US20130118996A1

  公开（公告）日：2013-05-16

  Methods for making asymmetrical triazines are provided. The methods comprise first forming a mixture of at least two primary amines then reacting the mixture with an aldehyde. Methods for removing sulfides from hydrocarbon streams are also provided. The triazines may be added to the hydrocarbon stream in a molar ratio of triazine:H 2 S of about 10:1 to about 1:2.

  本文提供了制备非对称三嗪的方法。该方法包括首先形成至少两种主要胺的混合物，然后将混合物与醛反应。本文还提供了从烃流中去除硫化物的方法。三嗪可以以三嗪：H2S的摩尔比约为10:1至约1:2的比例添加到烃流中。
• Method of reducing hydrogen sulfide levels in gaseous mixtures using triazines
  申请人：Dow Global Technologies LLC

  公开号：US10155911B2

  公开（公告）日：2018-12-18

  The present invention relates to a scavenging composition capable of scavenging a wide variety of sulfur-bearing compounds, such as hydrogen sulfide and method of use thereof. Said scavenging composition comprises an aqueous solution of a triazine compound, an anionic surfactant, and optionally an alcohol and/or glycol ether solution. The composition may be used in any kind of sulfide-scavenging operation and is particularly useful for sulfide scavenging in the context of sulfide removal from oil or gas streams and in the treatment of oil or gas transmission lines or equipment.

  本发明涉及一种能够清除多种含硫化合物（如硫化氢）的清除组合物及其使用方法。所述清除组合物包括一种三嗪化合物的水溶液、一种阴离子表面活性剂，以及可选的醇和/或乙二醇醚溶液。该组合物可用于任何类型的硫化物清除操作，尤其适用于清除石油或天然气流中的硫化物，以及处理石油或天然气输送管道或设备。
• FORMULATIONS ANTI-CORROSION STABLES AU STOCKAGE
  申请人：CECA S.A.

  公开号：EP3004421A1

  公开（公告）日：2016-04-13
• METHOD OF REDUCING HYDROGEN SULFIDE LEVELS IN LIQUID OR GASEOUS STREAMS USING COMPOSITIONS COMPRISING TRIAZINES AND ANIONIC SURFACTANTS
  申请人：Dow Global Technologies LLC

  公开号：EP3283600B1

  公开（公告）日：2019-09-25
• ANTI-CORROSION FORMULATIONS THAT ARE STABLE DURING STORAGE
  申请人：CECA S.A.

  公开号：US20160090655A1

  公开（公告）日：2016-03-31

  The present invention relates to formulations for inhibiting the corrosion of the metals used in the oil industry, and more generally in all types of industries for drilling for fossil compounds or ores, such as gas or oil. The corrosion-inhibiting formulations are stable during storage, and have improved properties due to the presence of at least one compound having at least one triazine unit. The invention also relates to the use of at least one compound comprising at least one triazine unit in a corrosion-inhibiting formulation, as well as to the use of said corrosion-inhibiting formulation in the oil, gas and mining industry.