1,3-二溴-2-(3-溴丙氧基)苯 | 206347-33-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1,3-二溴-2-(3-溴丙氧基)苯
• 中文别名: 1,3-二溴-2-(3-溴丙氧基)-苯
• 英文名称: Benzene, 1,3-dibromo-2-(3-bromopropoxy)-
• 英文别名: 1,3-dibromo-2-(3-bromopropoxy)benzene
• CAS: 206347-33-3
• 化学式: C₉H₉Br₃O
• 分子量: 372.882
• InChiKey: LMRBFBUUUIQJQA-UHFFFAOYSA-N

物化性质

• 沸点：
  360.8±32.0 °C(Predicted)
• 密度：
  1.942±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,3-二溴-2-(3-溴丙氧基)苯 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 生成 8-溴苯并二氢吡喃
  参考文献：
  名称：

  Synthesis of arylpiperazines via palladium-catalysed aromatic amination reactions of bromoarenes with N-tert-butoxycarbonylpiperazine

  摘要：

  Reaction of a series of bicyclic bromoarenes with N-tert-butoxycarbonylpiperazine (N-Boc-piperazine) under palladium-calalysed coupling conditions followed by routine removal of the Boc group with trifluoroacetic acid in dichloromethane gave the corresponding arylpiperazines in moderate to good yield. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00179-8
• 作为产物：
  描述：

  2,6-二溴苯酚 、 1,3-二溴丙烷 在 sodium hydroxide 作用下， 生成 1,3-二溴-2-(3-溴丙氧基)苯
  参考文献：
  名称：

  Synthesis of arylpiperazines via palladium-catalysed aromatic amination reactions of bromoarenes with N-tert-butoxycarbonylpiperazine

  摘要：

  Reaction of a series of bicyclic bromoarenes with N-tert-butoxycarbonylpiperazine (N-Boc-piperazine) under palladium-calalysed coupling conditions followed by routine removal of the Boc group with trifluoroacetic acid in dichloromethane gave the corresponding arylpiperazines in moderate to good yield. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00179-8

文献信息

• WO2008/82488
  申请人：——

  公开号：——

  公开（公告）日：——
• [EN] SULFOXIMINE GLYCOSIDASE INHIBITORS<br/>[FR] INHIBITEURS DE LA SULFOXIMINE GLYCOSIDASE
  申请人：ASCENEURON S A

  公开号：WO2018153508A2

  公开（公告）日：2018-08-30

  Compounds of formula (I) wherein A, R, W, Q, n and m have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.
• Synthesis of arylpiperazines via palladium-catalysed aromatic amination reactions of bromoarenes with N-tert-butoxycarbonylpiperazine
  作者：Frank Kerrigan、Claire Martin、Gerard H. Thomas

  DOI：10.1016/s0040-4039(98)00179-8

  日期：1998.4

  Reaction of a series of bicyclic bromoarenes with N-tert-butoxycarbonylpiperazine (N-Boc-piperazine) under palladium-calalysed coupling conditions followed by routine removal of the Boc group with trifluoroacetic acid in dichloromethane gave the corresponding arylpiperazines in moderate to good yield. (C) 1998 Elsevier Science Ltd. All rights reserved.