1,3-二甲基茚满 | 4175-53-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 中文名称: 1,3-二甲基茚满
• 英文名称: 1,3-dimethyl-2,3-dihydro-1H-indene
• 英文别名: 2,3-dihydro-1,3-dimethyl-1H-indene；1,3-Dimethyl-indan；1,3-dimethyl-indane；Trans-1,3-dimethylindan；1,3-Dimethylindan
• CAS: 4175-53-5
• 化学式: C₁₁H₁₄
• 分子量: 146.232
• InChiKey: IIJUYSSJMAITHJ-UHFFFAOYSA-N

物化性质

• 保留指数：
  1127;1135;1175.8

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• 海关编码：
  2902909090

反应信息

• 作为反应物：
  描述：

  1,3-二甲基茚满 在 硫酸 、 硝酸 作用下， 以 硝基甲烷 为溶剂， 生成 1,3-Dimethyl-5-nitro-indan
  参考文献：
  名称：

  Relative Reactivities of Some Benzocyclenes in Aromatic Nitration and Electrophilic Side-Chain Reaction.^1-5 A Remarkable Effect of the Bicyclo[2.2.1]heptene System

  摘要：

  DOI：

  10.1021/ja00949a024
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 乙醇 、 铂 作用下， 生成 1,3-二甲基茚满
  参考文献：
  名称：

  对于倍半萜的知识。（第79部分）。五元环中被取代的天青石

  摘要：

  DOI：

  10.1002/hlca.19470300525

文献信息

• Morpholino containing indane acetic acid esters
  申请人：Societe Anonyme dite: Societe Hexachimie

  公开号：US04069326A1

  公开（公告）日：1978-01-17

  The present invention relates to certain indane derivatives of general formula ##STR1## in which: X represents a hydrogen or halogen atom; R.sub.1 and R.sub.2, which may be identical or different, each represents a hydrogen atom, an alkyl group containing 1 to 5 carbon atoms or a cycloalkyl group containing 3 to 7 carbon atoms; R.sub.3 represents a hydrogen atom or an alkyl group containing 1 to 5 carbon atoms; and Y represents --CH.sub.2 OH or a group of formula --COOR.sub.4 in which R.sub.4 represents a hydrogen atom, 1/v(M) where M is a metal of valency v, or a group of formula --(CH.sub.2).sub.n --NR.sub.5 R.sub.6 wherein n is an integer of 1 to 5 and R.sub.5 and R.sub.6, which may be identical or different, each represents a hydrogen atom, an alkyl group containing 1 to 5 carbon atoms, a cycloalkyl group containing 3 to 7 carbon atoms, an aryl group or an aralkyl group, or R.sub.5 and R.sub.6, together with the nitrogen atom to which they are bonded, form an N-heterocyclic group with 5 to 7 ring members, which heterocyclic group optionally contains a second hetero-atom, and their pharmaceutically acceptable addition salts, and to processes for their preparation. The compounds of formula (I) and their salts are useful for the treatment of inflammations, algias, rheumatisms or pain syndromes in animals.

  本发明涉及一些具有一般式##STR1##的茚烷衍生物，其中：X代表氢或卤素原子；R.sub.1和R.sub.2可以相同也可以不同，分别代表含有1至5个碳原子的烷基或含有3至7个碳原子的环烷基的氢原子；R.sub.3代表氢原子或含有1至5个碳原子的烷基；Y代表--CH.sub.2 OH或式--COOR.sub.4的基团，其中R.sub.4代表氢原子，价态为v的金属M的1/v（M）或式--（CH.sub.2）.sub.n --NR.sub.5 R.sub.6的基团，其中n为1至5的整数，R.sub.5和R.sub.6可以相同也可以不同，分别代表氢原子、含有1至5个碳原子的烷基、含有3至7个碳原子的环烷基、芳基或芳基烷基，或R.sub.5和R.sub.6与它们结合的氮原子形成具有5至7个环成员的N-杂环基团，该杂环基团可以选择地包含第二个杂原子，以及它们的药学上可接受的加成盐和制备它们的方法。式（I）化合物及其盐在动物的炎症、疼痛、风湿病或疼痛综合征的治疗中是有用的。
• Indane derivatives
  申请人：Societe Hexachimie

  公开号：US04182896A1

  公开（公告）日：1980-01-08

  The present invention relates to certain indane derivatives of general formula ##STR1## in which: X represents a hydrogen or halogen atom; R.sub.1 and R.sub.2, which may be identical or different, each represents a hydrogen atom, an alkyl group containing 1 to 5 carbon atoms or a cycloalkyl group containing 3 to 7 carbon atoms; R.sub.3 represents a hydrogen atom or an alkyl group containing 1 to 5 carbon atoms; and Y represents --CH.sub.2 OH or a group of formula --COOR.sub.4 in which R.sub.4 represents a hydrogen atom, 1/v(M) where M is a metal of valency v, or a group of formula --(CH.sub.2).sub.n --NR.sub.5 R.sub.6 wherein n is an integer of 1 to 5 and R.sub.5 and R.sub.6, which may be identical or different, each represents an alkyl group containing 1 to 5 carbon atoms, a cycloalkyl group containing 3 to 7 carbon atoms, an aryl group or an aralkyl group, or R.sub.5 and R.sub.6, together with the nitrogen atom to which they are bonded, form an N-heterocyclic group with 5 to 7 ring members, which heterocyclic group optionally contains a second hetero-atom, and their pharmaceutically acceptable addition salts, and to processes for their preparation. The compounds of formula (I) and their salts are useful for the treatment of inflammations, algias, rheumatisms or pain syndromes in animals.

  本发明涉及一类一般式为##STR1##的茚烷衍生物，其中：X代表氢原子或卤素原子；R.sub.1和R.sub.2可以相同也可以不同，分别代表一个含有1至5个碳原子的烷基或一个含有3至7个碳原子的环烷基；R.sub.3代表氢原子或一个含有1至5个碳原子的烷基；Y代表--CH.sub.2 OH或公式--COOR.sub.4的基团，其中R.sub.4代表氢原子，1/v(M)（其中M是一个价数为v的金属），或公式--(CH.sub.2).sub.n --NR.sub.5 R.sub.6的基团，其中n为1至5的整数，R.sub.5和R.sub.6可以相同也可以不同，分别代表一个含有1至5个碳原子的烷基、一个含有3至7个碳原子的环烷基、一个芳基或一个芳基烷基，或者R.sub.5和R.sub.6与它们所连接的氮原子形成一个具有5至7个环成员的N-杂环基团，该杂环基团可以选择性地包含第二个杂原子，以及它们的药物可接受的加合盐，以及它们的制备方法。公式（I）化合物及其盐对于治疗动物的炎症、疼痛、风湿或疼痛综合征有用。
• Indane ethanols
  申请人：Societe Hexachimie

  公开号：US04088787A1

  公开（公告）日：1978-05-09

  The present invention relates to certain indane derivatives of general formula ##STR1## in which: X represents a hydrogen or halogen atom; R.sub.1 and R.sub.2, which may be identical or different, each represents a hydrogen atom, an alkyl group containing 1 to 5 carbon atoms or a cycloalkyl group containing 3 to 7 carbon atoms; R.sub.3 represents a hydrogen atom or an alkyl group containing 1 to 5 carbon atoms; and Y represents --CH.sub.2 OH or a group of formula --COOR.sub.4 in which R.sub.4 represents a hydrogen atom, 1/v(M) where M is a metal of valency v, or a group of formula --(CH.sub.2).sub.n --NR.sub.5 R.sub.6 wherein n is an integer of 1 to 5 and R.sub.5 and R.sub.6, which may be identical or different, each represents a hydrogen atom, an alkyl group containing 1 to 5 carbon atoms, a cycloalkyl group containing 3 to 7 carbon atoms, an aryl group or an aralkyl group, or R.sub.5 and R.sub.6, together with the nitrogen atom to which they are bonded, form an N-heterocyclic group with 5 to 7 ring members, which heterocyclic group optionally contains a second hetero-atom, and their pharmaceutically acceptable addition salts, and to processes for their preparation. The compounds of formula (I) and their salts are useful for the treatment of inflammations, algias, rheumatisms or pain syndromes in animals.

  本发明涉及一些一般式为##STR1##的茚烷衍生物，其中：X代表氢或卤原子；R.sub.1和R.sub.2，可能相同或不同，分别代表一个含有1至5个碳原子的烷基或一个含有3至7个碳原子的环烷基的氢原子；R.sub.3代表一个氢原子或一个含有1至5个碳原子的烷基；而Y代表--CH.sub.2 OH或式--COOR.sub.4的基团，其中R.sub.4代表一个氢原子、1/v(M)（其中M是价数为v的金属）或式--(CH.sub.2).sub.n --NR.sub.5 R.sub.6的基团，其中n是1至5的整数，而R.sub.5和R.sub.6，可能相同或不同，分别代表一个含有1至5个碳原子的烷基、一个含有3至7个碳原子的环烷基、一个芳基或一个芳基烷基，或者R.sub.5和R.sub.6与它们所连接的氮原子一起形成一个具有5至7个环成员的N-杂环基团，该杂环基团可选地包含第二个杂原子，以及它们的药学上可接受的加合物盐，以及它们的制备方法。式（I）化合物及其盐对于治疗动物的炎症、疼痛、风湿病或疼痛综合征具有用途。
• 887. Relation between hyperconjugation and conformation. Part III. Ethyl alcoholysis of some derivatives of diphenylmethyl chloride
  作者：G. Baddeley、M. Gordon

  DOI：10.1039/jr9580004379

  日期：——
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Cr: Org.Verb., 1.6.1.2.7, page 258 - 289
  作者：

  DOI：——

  日期：——

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