1,4-二甲氧基-2-(甲氧基甲基)-5-甲基苯 | 32176-89-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1,4-二甲氧基-2-(甲氧基甲基)-5-甲基苯
• 英文名称: 1,4-Dimethoxy-2-methoxymethyl-5-methyl-benzene
• 英文别名: 1,4-Dimethoxy-2-(methoxymethyl)-5-methylbenzene
• CAS: 32176-89-9
• 化学式: C₁₁H₁₆O₃
• 分子量: 196.246
• InChiKey: MEMVAKPCVJNATJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,4-二甲氧基-2-(甲氧基甲基)-5-甲基苯 在 Orange CRET^.+ 、 一氯化碘 、 锌 作用下， 以 二氯甲烷 为溶剂， 反应 0.58h， 生成 1-(氯甲基)-2,5-二甲氧基-4-甲基苯
  参考文献：
  名称：

  Radical-Cation Catalysis in the Synthesis of Diphenylmethanes via the Dealkylative Coupling of Benzylic Ethers

  摘要：

  The dealkylative coupling of benzyl alkyl ethers (ArCH(2)OR) to yield the corresponding diarylmethanes (ArCH2Ar) together with dialkoxymethane (ROCH(2)OR) is catalyzed by small amounts of 1-electron oxidants (such as aromatic cation radicals, NO+, etc.) or py an equivalent electrochemical (anodic) method. The catalytic method is successfully employed for the facile synthesis of a novel macrocyclic crown ether 18 that contains a diarylmethane linkage. On the basis of the spectral observation of the radical cation ArCH(2)OR(.+) and the excellent catalytic efficiency with turnover numbers in excess of 10(2), an electron-transfer and an alternative electrophilic chain mechanism are discussed for the dealkylative coupling process.

  DOI：

  10.1021/jo00128a020
• 作为产物：
  描述：

  2-(溴甲基)-5-甲基-1,4-二甲氧基苯 、 sodium methylate 以 甲醇 为溶剂， 反应 2.0h， 以96%的产率得到1,4-二甲氧基-2-(甲氧基甲基)-5-甲基苯
  参考文献：
  名称：

  Radical-Cation Catalysis in the Synthesis of Diphenylmethanes via the Dealkylative Coupling of Benzylic Ethers

  摘要：

  The dealkylative coupling of benzyl alkyl ethers (ArCH(2)OR) to yield the corresponding diarylmethanes (ArCH2Ar) together with dialkoxymethane (ROCH(2)OR) is catalyzed by small amounts of 1-electron oxidants (such as aromatic cation radicals, NO+, etc.) or py an equivalent electrochemical (anodic) method. The catalytic method is successfully employed for the facile synthesis of a novel macrocyclic crown ether 18 that contains a diarylmethane linkage. On the basis of the spectral observation of the radical cation ArCH(2)OR(.+) and the excellent catalytic efficiency with turnover numbers in excess of 10(2), an electron-transfer and an alternative electrophilic chain mechanism are discussed for the dealkylative coupling process.

  DOI：

  10.1021/jo00128a020

文献信息

• METHOD AND DEVICE FOR ELECTRONICALLY CONTROLLING THE PH OF A SOLUTION
  申请人：Robert Bosch GmbH

  公开号：EP3708673A1

  公开（公告）日：2020-09-16

  Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest by modulating the pH or ionic gradient near the electrodes in such biosensor. An electrochemically active agent that is suitable for use in biological buffers for changing the pH of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample.

  用于生物传感器的装置和方法，该生物传感器包括多检测点阵列，该装置和方法可通过调节生物传感器中电极附近的pH值或离子梯度来调节（生物分子）探针或检测剂与相关分析物之间的结合相互作用。适用于生物缓冲液的电化学活性剂，用于改变生物缓冲液的 pH 值。使用电化学活性剂改变生物缓冲液 pH 值的方法。生物传感器中提供的调节结合相互作用的方法、更精确地控制和测量这种生物传感器中电极附近的pH值或离子梯度的分析方法，以及更精确地测量生物样品中感兴趣的分析物的分析方法。
• Acid Catalysis vs. Electron-Transfer Catalysis via Organic Cations or Cation-Radicals as the Reactive Intermediate. Are These Distinctive Mechanisms?
  作者：Rajendra Rathore、Jay K. Kochi、Augusto Canavesi、Larry L. Miller、Giovanni V. Sebastiani、George W. Francis、József Szúnyog、Bengt Långström

  DOI：10.3891/acta.chem.scand.52-0114

  日期：——

  Proton transfer to aromatic and olefinic donors (D) lends to the facile interchange of transient carbocations (DH+) and cation-radical (D+.). The same types of cation and cation-radical are reactive intermediates in the acid catalysis and the electron-transfer catalysis of such organic transformations as benzylic coupling, epoxide.-pinacol rearrangements and cis-trans isomerization of stilbenes when they are both carried out under otherwise identical reaction conditions, However, the rapid exchange of diamagnetic cations and paramagnetic cation-radicals blurs the traditional view of sepal ate electrophilic and homolytic processes, and rigorous experimental evidence is required to establish whether acid catalysis and electron-transfer catalysis actually represent distinct mechanistic categories.