1,6,7,8-四氢喹啉-4,5-二酮 | 143261-90-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1,6,7,8-四氢喹啉-4,5-二酮
• 英文名称: 1,4,5,6,7,8-Hexahydroquinoline-4,5-dione
• 英文别名: 7,8-Dihydroquinoline-4,5(1H,6H)-dione；1,6,7,8-tetrahydroquinoline-4,5-dione
• CAS: 143261-90-9
• 化学式: C₉H₉NO₂
• mdl: MFCD18802952
• 分子量: 163.176
• InChiKey: RCYRGXOFTDOXQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,6,7,8-四氢喹啉-4,5-二酮 在 sodium azide 、 硫酸 作用下， 以 氯仿 为溶剂， 反应 10.0h， 以55%的产率得到4,5-dihydro-3H-isoxazolo<5,4,3-de>quinoline
  参考文献：
  名称：

  Synthesis of 1,2,3,4-Tetrahydroacridine and 5,6,7,8-Tetrahydroquinoline Derivatives as Potential Acetylcholinesterase Inhibitors

  摘要：

  This paper describes the synthesis of 1,3,4,5-tetrahydropyrazolo[3,4,5-kl]acridine (2) and 11-amino-1,3,4,5-tetrahydro-azepino[3,2-b]quinolin-2-one (3) obtained by Schmidt reaction of 9-amino-3,4-dihydroacridin-1(2H)-one (1) and the preparation of 4,5-dihydro-3H-isoxazolo[3,4,5-kl]acridine (7) obtained in the same manner starting f rom 3, 4-dihydroacridine-1, 9 (2H, 10H) -dione (6) . The corresponding pyrazolo[3,4,5-de]quinoline (20) and isoxazolo[5,4,3-de]quinoline (18) are also reported. The compounds have been prepared with the aim of studying their possible activity as acetylcholinesterase inhibitors.

  DOI：

  10.3987/com-92-5977
• 作为产物：
  描述：

  3-氨基-2-环己烯-1-酮 以 二苯醚 、 乙醇 为溶剂， 反应 2.5h， 生成 1,6,7,8-四氢喹啉-4,5-二酮
  参考文献：
  名称：

  Synthesis of 1,2,3,4-Tetrahydroacridine and 5,6,7,8-Tetrahydroquinoline Derivatives as Potential Acetylcholinesterase Inhibitors

  摘要：

  This paper describes the synthesis of 1,3,4,5-tetrahydropyrazolo[3,4,5-kl]acridine (2) and 11-amino-1,3,4,5-tetrahydro-azepino[3,2-b]quinolin-2-one (3) obtained by Schmidt reaction of 9-amino-3,4-dihydroacridin-1(2H)-one (1) and the preparation of 4,5-dihydro-3H-isoxazolo[3,4,5-kl]acridine (7) obtained in the same manner starting f rom 3, 4-dihydroacridine-1, 9 (2H, 10H) -dione (6) . The corresponding pyrazolo[3,4,5-de]quinoline (20) and isoxazolo[5,4,3-de]quinoline (18) are also reported. The compounds have been prepared with the aim of studying their possible activity as acetylcholinesterase inhibitors.

  DOI：

  10.3987/com-92-5977

文献信息

• Groundwater, Paul W.; Munawar, Munawar Ali, Journal of the Chemical Society. Perkin transactions I, 1997, # 22, p. 3381 - 3385
  作者：Groundwater, Paul W.、Munawar, Munawar Ali

  DOI：——

  日期：——
• Synthesis of 1,2,3,4-Tetrahydroacridine and 5,6,7,8-Tetrahydroquinoline Derivatives as Potential Acetylcholinesterase Inhibitors
  作者：Franco Gatta、Maria Rosaria Del Giudice、Massimo Pomponi、Maurizio Marta

  DOI：10.3987/com-92-5977

  日期：——

  This paper describes the synthesis of 1,3,4,5-tetrahydropyrazolo[3,4,5-kl]acridine (2) and 11-amino-1,3,4,5-tetrahydro-azepino[3,2-b]quinolin-2-one (3) obtained by Schmidt reaction of 9-amino-3,4-dihydroacridin-1(2H)-one (1) and the preparation of 4,5-dihydro-3H-isoxazolo[3,4,5-kl]acridine (7) obtained in the same manner starting f rom 3, 4-dihydroacridine-1, 9 (2H, 10H) -dione (6) . The corresponding pyrazolo[3,4,5-de]quinoline (20) and isoxazolo[5,4,3-de]quinoline (18) are also reported. The compounds have been prepared with the aim of studying their possible activity as acetylcholinesterase inhibitors.