1-(2,3-二氯苯基)-2,2-二甲基-1-丙酮 | 898766-54-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-(2,3-二氯苯基)-2,2-二甲基-1-丙酮
• 英文名称: 2',3'-Dichloro-2,2-dimethylpropiophenone
• 英文别名: 1-(2,3-dichlorophenyl)-2,2-dimethylpropan-1-one
• CAS: 898766-54-6
• 化学式: C₁₁H₁₂Cl₂O
• 分子量: 231.11
• InChiKey: HWMZHBFTGIGLBA-UHFFFAOYSA-N

物化性质

• 沸点：
  285.6±25.0 °C(Predicted)
• 密度：
  1.188±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2914700090

文献信息

• CONSTRUCTION AND SCREENING OF SOLUTION-PHASE DERIVED LIBRARY OF FENBUFEN AND ETHACRYNIC ACID
  申请人：Yu Chung-Shan

  公开号：US20110306668A1

  公开（公告）日：2011-12-15

  A process for synthesizing and screening solution phase derived libraries of fenbufen and ethacrynic acid is provided in the present invention. Compounds in the present invention having cytotoxicities are useful for a variety of therapeutic applications.

  本发明提供了一种合成和筛选溶液相衍生的芬布芬和依他克酸库的过程。本发明中具有细胞毒性的化合物对多种治疗应用是有用的。
• PEPTIDYL INHIBITORS OF CALCINEURIN-NFAT INTERACTION
  申请人：Ohio State Innovation Foundation

  公开号：US20210169966A1

  公开（公告）日：2021-06-10

  Described are peptides and peptide conjugates comprising CN binding motifs (CNBM) which inhibit the CN-NFAT interaction. In some embodiments, the peptides comprise: (i) CNBM; (ii) a hydrophobic, non-peptidic moiety (RH) which interacts with the hydrophobic pocket on a CN protein; (iii) a sequence -AAU1-AAU2-AAU3-AAU4-AAU5-AAU6-, wherein each of AAU2, AAU3, AAU4, AAU5, and AAU6, is, independently, optional, and each of AAU, AAU2, AAU3, AAU4, AAU5, and AAU6 when present is independently an amino acid as defined herein; or (iv) combinations thereof. In some embodiments, RH is conjugated to the N- or C-terminus of the CNBM. In some embodiments, the sequence -AAU1-AAU2-AAU3-AAU4-AAU5-AAU6- is conjugated to the N- or C terminus of the CNBM. In some embodiments, the peptides comprise: CNBM and RH. In some embodiments. In some embodiments, the peptides comprise: CNBM and AAU1-AAU2-AAU3-AAU4-AAU5-AAU6-. In some embodiments, the peptides of the disclosure CNBM and RH.
• US7645771B2
  申请人：——

  公开号：US7645771B2

  公开（公告）日：2010-01-12
• US8093427B2
  申请人：——

  公开号：US8093427B2

  公开（公告）日：2012-01-10