1-(2-乙酰基四氢-6alpha-羟基-2,3A,5-三甲基呋喃并[2,3-d]-1,3-二氧杂环戊烯-5-基)-乙酮 | 18114-49-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-(2-乙酰基四氢-6alpha-羟基-2,3A,5-三甲基呋喃并[2,3-d]-1,3-二氧杂环戊烯-5-基)-乙酮
• 英文名称: 2,5-Diacetyl-3a,5,6,6a-tetrahydro-6a-hydroxy-2,3a,5-trimethyl-furo<2.3-d>-1,3-dioxal
• 英文别名: 1,1'-(Tetrahydro-6a-hydroxy-2,3a,5-trimethylfuro[2,3-d]-1,3-dioxole-2,5-diyl)bis-ethanone；1-(2-acetyl-6a-hydroxy-2,3a,5-trimethyl-6H-furo[2,3-d][1,3]dioxol-5-yl)ethanone
• CAS: 18114-49-3
• 化学式: C₁₂H₁₈O₆
• 分子量: 258.271
• InChiKey: TXTNKDRGVWKECN-UHFFFAOYSA-N

物化性质

• 沸点：
  370.2±42.0 °C(Predicted)
• 密度：
  1.279±0.06 g/cm3(Predicted)
• LogP：
  4.907 (est)
• 物理描述：
  Yellowish solid; Roasted buttery aroma
• 溶解度：
  Sparingly soluble in water

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  82.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  申请人：Senomyx, Inc.

  公开号：US20170096418A1

  公开（公告）日：2017-04-06

  The present disclosure relates to compounds which are useful as cooling sensation compounds.

  本公开涉及作为冷感化合物有用的化合物。
• USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS
  申请人：Krammer Gerhard

  公开号：US20100233102A1

  公开（公告）日：2010-09-16

  The invention provides the use of a 4-hydroxydihydrochalcone of the formula (I) wherein R 1 , R 2 , R 3 and R 4 each, independently, represent H, OH or O-alkyl, with the proviso that at least one of the groups R 1 , R 2 or R 3 represents OH, a salt of such a 4-hydroxydihydrochalcone of the formula (I), a mixture containing or consisting of two or more different 4-hydroxydihydrochalcones of the formula (I), wherein R 1 , R 2 , R 3 and R 4 are each defined in the way given above, a mixture containing or consisting of salts of two or more different 4-hydroxydihydrochalcones of the formula (I), wherein R 1 , R 2 , R 3 and R 4 are each defined in the way given above or a mixture containing or consisting of a 4-hydroxydihydrochalcone of the formula (I) or two or more different 4-hydroxydihydrochalcones of the formula (I), wherein R 1 , R 2 , R 3 and R 4 are each defined in the way given above, and a salt of a 4-hydroxydihydrochalcone of the formula (I) or two or more salts of different 4-hydroxydihydrochalcones of the formula (I), wherein R 1 , R 2 , R 3 and R 4 are each defined in the way given above, to enhance the sweet taste of a sweet-tasting substance or the impression of a sweet smell of a flavouring that gives an impression of a sweet smell.

  本发明提供使用式(I)的4-羟基二氢查尔酮，其中R1、R2、R3和R4各自独立地表示H、OH或O-烷基，但至少其中一个基团R1、R2或R3表示OH，以及该式(I)的4-羟基二氢查尔酮的盐，含有或由两种或更多不同的式(I)的4-羟基二氢查尔酮混合而成，其中R1、R2、R3和R4的定义如上所述，含有或由两种或更多不同的式(I)的4-羟基二氢查尔酮的盐混合而成，其中R1、R2、R3和R4的定义如上所述，含有或由式(I)的4-羟基二氢查尔酮或两种或更多不同的式(I)的4-羟基二氢查尔酮混合而成，其中R1、R2、R3和R4的定义如上所述，以及式(I)的4-羟基二氢查尔酮的盐或两种或更多不同的式(I)的4-羟基二氢查尔酮的盐混合而成，用于增强甜味物质的甜味或给予甜味香料的甜味印象。
• Verwendung von Propenylphenylglycosiden zur Verstärkung süßer sensorischer Eindrücke
  申请人：Symrise GmbH & Co. KG

  公开号：EP1955601A1

  公开（公告）日：2008-08-13

  Die Erfindung betrifft die Verwendung - eines Propenylphenylglycosids der Formel (I) wobei R entweder (1 E)-Prop-1-enyl-, (1 Z)-Prop-1 -enyl- oder Prop-2-enyl- darstellt und Glc ein α- oder β-glycosidisch gebundenes Mono- oder Oligosaccharid sein kann zur Verstärkung des süßen Geschmacks eines süß schmeckenden Stoffes oder des süßen Geruchseindrucks eines Aromastoffes, der einen süßen Geruchseindruck verursacht.

  本发明涉及使用 - 式 (I) 的丙烯基苯基糖苷的用途 式中 R 代表(1 E)-丙-1-烯基、(1 Z)-丙-1-烯基或丙-2-烯基 和 Glc 可以是α-或β-糖苷键合的单糖或寡糖 用于增强甜味物质的甜味，或增强能产生甜味的调味物质的甜味。
• Compounds useful as modulators of TRPM8
  申请人：Senomyx, Inc.

  公开号：US10392371B2

  公开（公告）日：2019-08-27

  Provided herein are compounds which are useful as cooling sensation compounds.

  本文提供的化合物可用作冷感化合物。