1,3,4-Trimethyl-5-methoxypyrazole

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,3,4-Trimethyl-5-methoxypyrazole
• 英文别名: 5-methoxy-1,3,4-trimethylpyrazole
• 化学式: C₇H₁₂N₂O
• 分子量: 140.18
• InChiKey: LHLQNFGYHMTKHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS<br/>[FR] LACTAMES SUBSTITUÉS PAR LE PIPÉRIDINYLE COMME MODULATEURS DE GPR119
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2013066869A1

  公开（公告）日：2013-05-10

  Compounds of Formula (I) and pharmaceutically acceptable salts thereof in which X1, X2, X3, L, R3, R4, R5, R7 and n have the meanings given in the specification, are modulators of GPR119 and are useful in the treatment or prevention of diseases such as such as, but not limited to, type 2 diabetes, diabetic complications, symptoms of diabetes, metabolic syndrome, obesity, dyslipidemia, and related conditions.

  式（I）的化合物及其药学上可接受的盐，其中X1、X2、X3、L、R3、R4、R5、R7和n的含义如规范中所述，是GPR119的调节剂，并且在治疗或预防诸如但不限于2型糖尿病、糖尿病并发症、糖尿病症状、代谢综合征、肥胖、血脂异常及相关疾病方面是有用的。
• N-((3-BENZYL)-2,2-(BIS-PHENYL)-PROPAN-1-AMINE DERIVATIVES AS CETP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROSIS AND CARDIOVASCULAR DISEASES
  申请人：Bristol-Myers Squibb Company

  公开号：US20130184279A1

  公开（公告）日：2013-07-18

  Compounds of formula Ia and Ib wherein A, B, C, R 1 and R 14 are described herein.

  公式Ia和Ib的化合物，其中A、B、C、R1和R14的描述如下。
• AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF
  申请人：Sinochem Corporation

  公开号：EP2281810A1

  公开（公告）日：2011-02-09

  Amide compounds, preparation methods and uses thereof. The structure of the compounds is represented as the general formula (I), in which the definitions of substituents are illuminated as description. The present amide compounds have broad spectrum activity of killing pests and are effective on lepidopteran pests including ostrinia nubilalis, sugarcane borer, adoxophyes orana fischer von reslerstamm, apple fruit borer, grapholitha inopinata, lymantri dispar 1., cnaphalocrocis medinalis, ostrinia furnacalis, helicoverpa assulta, grapholitha inopinata, plutella xylostella, spodoptera exigua, prodenia litura etc., especially for plutella xylostella, spodoptera exigua. The present amide compounds can obtain good effect at very low dosage. At the same time, some compounds have good fungicidal activity which can be used to prevent rice blast, phytophthora infestans, cucumber downy mildew or grey mould of vegetables.

  酰胺化合物、制备方法及其用途。这些化合物的结构如通式（I）所示，其中取代基的定义如图所示。 本发明的酰胺类化合物具有广谱杀虫活性，对鳞翅目害虫有效，这些害虫包括桔梗、甘蔗蛀虫、adoxophyes orana fischer von reslerstamm、苹果蠹蛾、grapholitha inopinata、lymantri dispar 1.medinalis、otrinia furnacalis、helicoverpa assulta、grapholitha inopinata、plutella xylostella、spodoptera exigua、prodenia litura 等、特别是对木虱和鞘翅目幼虫。目前的酰胺类化合物可以在很低的剂量下获得很好的效果。同时，一些化合物还具有良好的杀菌活性，可用于防治稻瘟病、疫霉病、黄瓜霜霉病或蔬菜灰霉病。
• US20140256756A1
  申请人：——

  公开号：US20140256756A1

  公开（公告）日：2014-09-11
• US8404896B2
  申请人：——

  公开号：US8404896B2

  公开（公告）日：2013-03-26