The present invention relates to a new method of manufacturing the compound 1-[2-[4-[5-chloro-1-(4-fluorophenyl)-1-H-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinone having the recommended INN name sertindole and a new method of manufacturing the intermediates, N-(4-fluorophenyl)-N-(2-carboxy-4-chlorophenyl)glycine and 5-chloro-1-(4-fluorophenyl)-3-(1,2,3,6-tetrahydropyridin-4-yl)indole used in the method.
本发明涉及一种制造新复合物1-[2-[4-[
5-氯-1-(4-氟苯基)-1H-吲哚-3-基]-1-
哌啶基]乙基]-
2-咪唑烷酮(建议采用INN名字sertindole)的新方法,以及制造该方法中使用的中间体N-(4-
氟苯基)-N-(2-羧基-4-
氯苯基)甘
氨酸和5-
氯-1-(4-
氟苯基)-3-(
1,2,3,6-四氢吡啶-4-基)
吲哚的新方法。