1-(2-溴乙氧基)-4-苯氧基苯 | 87545-48-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(2-溴乙氧基)-4-苯氧基苯
• 英文名称: 2-bromo-1-(4-phenoxyphenoxy)ethane
• 英文别名: 1-(4-(2-bromoethoxy)phenoxy)benzene；4-phenoxphenoxyethyl bromide；1-(2-bromo-ethoxy)-4-phenoxy-benzene；2-(4-Phenoxy-phenoxy)-aethylbromid；O-(2-Brom-aethyl)-O'-phenyl-hydrochinon；1-(2-Brom-aethoxy)-4-phenoxy-benzol；4-(2-bromoethoxy)-1-phenoxybenzene；1-(2-Bromoethoxy)-4-phenoxybenzene
• CAS: 87545-48-0
• 化学式: C₁₄H₁₃BrO₂
• mdl: MFCD00446389
• 分子量: 293.16
• InChiKey: DHBGFBFDCPJARX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(2-溴乙氧基)-4-苯氧基苯 在 sodium hydroxide 、 四丁基溴化铵 、 硫酸羟胺 、 三乙胺 作用下， 以 水 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 11.0h， 生成 O-[2-(4-Phenoxyphenoxy)ethyl]hydroxylamine
  参考文献：
  名称：

  Ohsumi, Tadashi; Hatakoshi, Makoto; Kisida, Hirosi, Agricultural and Biological Chemistry, 1985, vol. 49, # 11, p. 3197 - 3202

  摘要：

  DOI：
• 作为产物：
  描述：

  4-苯氧基苯酚 在 N-溴代丁二酰亚胺(NBS) 、 4-甲基苯磺酸吡啶 、 三苯基膦 、 potassium hydroxide 作用下， 以 甲醇 、 二氯甲烷 、 二甲基亚砜 为溶剂， 反应 32.0h， 生成 1-(2-溴乙氧基)-4-苯氧基苯
  参考文献：
  名称：

  含硒的WC-9类似物对克氏锥虫的进一步见解。

  摘要：

  作为我们旨在寻找针对美国锥虫病（Chagas病）的新化学治疗剂的项目的延续，针对该疾病的病原体克氏锥虫的临床上更相关的划分形式，设计，合成了新的硒氰酸酯衍生物，并对其进行了生物学评估。另外，为了确立硒氰酸酯部分的每个部分的作用，构思，合成和生物学评估了其中不存在硒原子或氰基的不同衍生物。此外，为了研究末端苯氧基的最佳位置，合成了新的WC-9区域异构体，并针对克鲁氏梭菌进行了评估。最后，WC-9的强效构象刚性类似物的外消旋混合物的拆分已完成，并已进一步测试过，可作为克氏锥虫增殖的生长抑制剂。该结果提供了关于硒氰酸酯基团在其抗寄生虫活性中的作用的进一步见解。

  DOI：

  10.1016/j.bmc.2019.02.039

文献信息

• Insect Juvenile Hormone Analogues and Their Biological Activity on Sea Lice (<i>Lepeophtheirus salmonis</i>)
  作者：Lars Skattebøl、Yngve Stenstrøm、Christian Syvertsen

  DOI：10.1021/jf049259h

  日期：2004.11.1

  A number of synthetic compounds that exhibit juvenile hormone activity when tested on the insect species Tenebrio molitor have been shown to inhibit the development of the sea lice species Lepeophtheirus salmonis. The testing was carried out on both isolated nauplius larvae and live Atlantic salmon (Salmo salar).

  对昆虫黄粉虫进行测试时，已显示出许多显示少年激素活性的合成化合物可抑制海虱物种鲑鱼麻风病的发展。对分离的无节幼体幼鱼和活的大西洋鲑鱼（Salmo salar）均进行了测试。
• ARYL AMINO ACID DERIVATIVES AS INHIBITORS FOR TREATING INFLAMMATION
  申请人：Sandanayaka Vincent

  公开号：US20080033024A1

  公开（公告）日：2008-02-07

  The present invention relates to a chemical genus of 3-(triaryl)-2-aminopropanol derivative inhibitors of LTA4H (leukotriene A4 hydrolase) useful for the treatment and prevention of inflammatory diseases and disorders. The compounds have general formula III: A particular embodiment is

  本发明涉及一种化学类别的3-(三芳基)-2-氨基丙醇衍生物，它们是LTA4H (白三烯A4水解酶)的抑制剂，可用于治疗和预防炎症性疾病和紊乱。这些化合物具有通用的化学式III:一种特定的实施方式是
• Nitrogen-containing heterocyclic compounds, and their production and use
  申请人：Sumitomo Chemical Company, Limited

  公开号：US04970222A1

  公开（公告）日：1990-11-13

  A nitrogen-containing heterocyclic compound of the formula: ##STR1## wherein R.sub.1 is either one of the following groups: ##STR2## (in which R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12, R.sub.13, R.sub.14, R.sub.15, R.sub.16 and R.sub.17 are, the same or different, each a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.4 alkyl group, a C.sub.1 -C.sub.4 alkoxy group, a C.sub.1 -C.sub.4 alkylthio group, a trifluoromethyl group or a nitro group, R.sub.18, R.sub.19, R.sub.20 and R.sub.21 are, the same or different, each a hydrogen atom or a methyl group, k is an integer of 0 to 1 and l is an integer of 0 to 3); R.sub.2 and R.sub.3 are, the same or different, each a hydrogen atom, a halogen atom or a methyl group; R.sub.4 is a halogen atom or a methyl group; R.sub.5 and R.sub.6 are, the same or different, each a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.4 alkyl group, a C.sub.1 -C.sub.4 alkoxy group, a C.sub.1 -C.sub.4 haloalkyl group or a C.sub.1 -C.sub.4 haloalkoxy group; X, Y and Z are, the same or different, each an oxygen atom, a sulfur atom or a methylene group; m is an integer of 0 to 4; and n is an integer of 0 to 2, which is useful as an insecticidal agent.

  一种含氮杂环化合物，化学式为：##STR1## 其中R.sub.1是以下任意一种基团之一：##STR2##（其中R.sub.7，R.sub.8，R.sub.9，R.sub.10，R.sub.11，R.sub.12，R.sub.13，R.sub.14，R.sub.15，R.sub.16和R.sub.17是相同或不同的氢原子，卤素原子，C.sub.1-C.sub.4烷基，C.sub.1-C.sub.4烷氧基，C.sub.1-C.sub.4烷硫基，三氟甲基或硝基，R.sub.18，R.sub.19，R.sub.20和R.sub.21是相同或不同的氢原子或甲基，k是0到1的整数，l是0到3的整数）；R.sub.2和R.sub.3是相同或不同的氢原子，卤素原子或甲基；R.sub.4是卤素原子或甲基；R.sub.5和R.sub.6是相同或不同的氢原子，卤素原子，C.sub.1-C.sub.4烷基，C.sub.1-C.sub.4烷氧基，C.sub.1-C.sub.4卤代烷基或C.sub.1-C.sub.4卤代烷氧基；X，Y和Z是相同或不同的氧原子，硫原子或亚甲基基团；m是0到4的整数；n是0到2的整数，该化合物可用作杀虫剂。
• Certain 2-pyridyloxy-lower alkylene-oxy-phenoxy compounds, thio-and
  申请人：Sumitomo Chemical Company, Limited

  公开号：US04751225A1

  公开（公告）日：1988-06-14

  A nitrogen-containing heterocyclic compound of the formula: ##STR1## wherein R.sub.1 is either one of the following groups: ##STR2## (in which R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12, R.sub.13, R.sub.14, R.sub.15, R.sub.16 and R.sub.17 are, the same or different, each a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.4 alkyl group, a C.sub.1 -C.sub.4 alkoxy group, a C.sub.1 -C.sub.4 alkylthio group, a trifluoromethyl group or a nitro group, R.sub.18, R.sub.19, R.sub.20 and R.sub.21 are, the same or different, each a hydrogen atom or a methyl group, k is an integer of 0 to 1 and l is an integer of 0 to 3); R.sub.2 and R.sub.3 are, the same or different, each a hydrogen atom, a halogen atom or a methyl group; R.sub.4 is a halogen atom or a methyl group; R.sub.5 and R.sub.6 are, the same or different, each a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.4 alkyl group, a C.sub.1 -C.sub.4 alkoxy group, a C.sub.1 -C.sub.4 haloalkyl group or a C.sub.1 -C.sub.4 haloalkoxy group; X, Y and Z are, the same or different, each an oxygen atom, a sulfur atom or a methylene group; m is an integer of 0 to 4; and n is an integer of 0 to 2, which is useful as an insecticidal agent.

  一种含氮杂环化合物，其化学式为：##STR1## 其中R.sub.1是以下任意一种基团之一： ##STR2## （其中R.sub.7，R.sub.8，R.sub.9，R.sub.10，R.sub.11，R.sub.12，R.sub.13，R.sub.14，R.sub.15，R.sub.16和R.sub.17是相同或不同的氢原子，卤素原子，C.sub.1-C.sub.4烷基，C.sub.1-C.sub.4烷氧基，C.sub.1-C.sub.4烷硫基，三氟甲基或硝基，R.sub.18，R.sub.19，R.sub.20和R.sub.21是相同或不同的氢原子或甲基，k是0到1的整数，l是0到3的整数）；R.sub.2和R.sub.3是相同或不同的氢原子，卤素原子或甲基；R.sub.4是卤素原子或甲基；R.sub.5和R.sub.6是相同或不同的氢原子，卤素原子，C.sub.1-C.sub.4烷基，C.sub.1-C.sub.4烷氧基，C.sub.1-C.sub.4卤代烷基或C.sub.1-C.sub.4卤代烷氧基；X、Y和Z是相同或不同的氧原子，硫原子或亚甲基基团；m是0到4的整数；n是0到2的整数，该化合物可用作杀虫剂。
• Certain-phenoxy-phenoxy-alkylene-oxy-pyrimidines or symmetrical
  申请人：Sumitomo Chemical Company, Limited

  公开号：US04879292A1

  公开（公告）日：1989-11-07

  A nitrogen-containing heterocyclic compound of the formula: ##STR1## wherein R.sub.1 is either one of the following groups: ##STR2## (in which R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12, R.sub.13, R.sub.14, R.sub.15, R.sub.16 and R.sub.17 are, the same or different, each a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.4 alkyl group, a C.sub.1 -C.sub.4 alkoxy group, a C.sub.1 -C.sub.4 alkylthio group, a trifluoromethyl group or a nitro group, R.sub.18, R.sub.19, R.sub.20 and R.sub.21 are, the same or different, each a hydrogen atom or a methyl group, k is an integer of 0 to 1 and l is an integer of 0 to 3); R.sub.2 and R.sub.3 are, the same or differnt, each a hydrogen atom, a halogen atom or a methyl group; R.sub.4 is a halogen atom or a methyl group; R.sub.5 and R.sub.6 are, the same or different, each a hydrogen atom, a halogen atom, a C.sub.1 -C.sub.4 alkyl group, a C.sub.1 -C.sub.4 alkoxy group, a C.sub.1 -C.sub.4 haloalkyl group or a C.sub.1 -C.sub.4 haloalkoxy group; X, Y and Z are, the same or different, each an oxygen atom, a sulfur atom or a methylene group; m is an integer of 0 to 4; and n is an integer of 0 to 2, which is useful as an insecticidal agent.

  一种含氮杂环化合物的化学式为：##STR1## 其中R.sub.1是以下任一基团之一：##STR2## （其中R.sub.7，R.sub.8，R.sub.9，R.sub.10，R.sub.11，R.sub.12，R.sub.13，R.sub.14，R.sub.15，R.sub.16和R.sub.17是相同或不同的氢原子，卤素原子，C.sub.1-C.sub.4烷基，C.sub.1-C.sub.4烷氧基，C.sub.1-C.sub.4烷硫基，三氟甲基或硝基；R.sub.18，R.sub.19，R.sub.20和R.sub.21是相同或不同的氢原子或甲基，k是0到1的整数，l是0到3的整数）；R.sub.2和R.sub.3是相同或不同的氢原子，卤素原子或甲基；R.sub.4是卤素原子或甲基；R.sub.5和R.sub.6是相同或不同的氢原子，卤素原子，C.sub.1-C.sub.4烷基，C.sub.1-C.sub.4烷氧基，C.sub.1-C.sub.4卤代烷基或C.sub.1-C.sub.4卤代烷氧基；X，Y和Z是相同或不同的氧原子，硫原子或亚甲基基团；m是0到4的整数；n是0到2的整数。该化合物可用作杀虫剂。