2-(4-phenoxyphenoxy)ethylamine | 72490-14-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-phenoxyphenoxy)ethylamine
• 英文别名: 4-phenoxyphenoxyethyl amine；2-(4-Phenoxyphenoxy)ethanamine
• CAS: 72490-14-3
• 化学式: C₁₄H₁₅NO₂
• mdl: MFCD09736436
• 分子量: 229.279
• InChiKey: FBLANPWAVFBRNS-UHFFFAOYSA-N

物化性质

• 沸点：
  364.5±27.0 °C(Predicted)
• 密度：
  1.122±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于碱性水溶液

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(4-phenoxyphenoxy)ethylamine 在 盐酸 、 水 作用下， 以 二氯甲烷 为溶剂， 生成 1-[(4-phenoxyphenoxyethylamino)ethyl]-1,1-bisphosphonic acid
  参考文献：
  名称：

  WC-9 的含氟类似物和结构相关类似物对抗两种细胞内寄生虫：克氏锥虫和弓形虫的活性

  摘要：

  两种专性细胞内寄生虫，克氏锥虫（恰加斯病的病原体）和弓形虫（弓形虫病的病原体），在感染后上调宿主细胞的甲羟戊酸途径，这表明该宿主途径可能是潜在的药物靶点。在这项工作中，设计、合成了许多结构与WC-9 （4-苯氧基苯氧基乙基硫氰酸酯）（一种已知的角鲨烯合酶抑制剂）相关的化合物，并评估了它们对组织培养细胞中克氏弓形虫和刚地弓形虫生长的影响。两种含氟衍生物，3-(3-氟苯氧基)-和3-(4-氟苯氧基)苯氧基乙基硫氰酸盐，针对T的速殖子表现出半最大有效浓度(EC 50 )值分别为1.6和4.9μm 。 .​​​​此外，2-[3-（苯氧基）苯氧基乙硫基]乙基-1,1-二膦酸酯是一种含有 3-苯氧基苯氧基和二膦酸酯基团的混合抑制剂，具有亚微摩尔水平的抗弓形虫增殖活性（EC 50 = 0.7 μ m ），这表明两个官能团的联合抑制作用。

  DOI：

  10.1002/cmdc.201600505
• 作为产物：
  描述：

  1-(2-溴乙氧基)-4-苯氧基苯 在 ammonium hydroxide 作用下， 生成 2-(4-phenoxyphenoxy)ethylamine
  参考文献：
  名称：

  Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives

  摘要：

  The synthesis and biological evaluation of a series of diphenyl ether derivatives were described. The compounds can either activate or inhibit the aminopeptidase activity of leukotriene A(4) hydrolase, while at the same time do not influence the hydrolase activity. Further enzyme kinetics and molecular modeling investigation on these novel chemical activators revealed their possible activation mechanism. These compounds can be used as probes to regulate the aminopeptidase activity of leukotriene A4 hydrolase. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.10.044

文献信息

• Synthesis of Haptens and Protein Conjugates for the Development of Immunoassays for the Insect Growth Regulator Fenoxycarb
  作者：Ferenc Szurdoki、András Székács、Hong M. Le、Bruce D. Hammock

  DOI：10.1021/jf0107050

  日期：2002.1.1

  The parent molecule [ethyl 2-(4-phenoxyphenoxy)ethylcarbamate] was derivatized at several positions to obtain haptens (2-5) that were used to produce protein conjugates and rabbit polyclonal antisera. Amino derivatives of fenoxycarb at the terminal and internal rings (2 and 3, respectively) were linked to carrier proteins by azo coupling. Carboxyalkyl-spacer groups were attached to the ethyl group and

  针对昆虫生长调节剂（IGR）的苯氧威（1）开发了固定抗原形式的灵敏和选择性酶联免疫吸附测定（ELISA）。将母体分子[2-（4-苯氧基苯氧基）乙基氨基甲酸酯]在几个位置上衍生化，得到半抗原（2-5），用于生产蛋白结合物和兔多克隆抗血清。末端和内部环（分别为2和3）上的苯氧威的氨基衍生物通过偶氮偶合与载体蛋白连接。将羧基烷基-间隔基连接到目标化合物（1）的乙基和氮原子上，分别获得半抗原4和5。基于化合物2和4的蛋白质结合物进行的半抗原同源ELISA测定的苯氧威含量在中ppb范围内（分别为IC（50），102和95 ppb）。
• [EN] CATALYTIC HYDROGENATION OF NITRILES TO PRODUCE CAPSAICINOID DERIVATIVES AND AMINE COMPOUNDS, AND METHODS FOR PURIFIYING AND OBTAINING THE POLYMORPHS THEREOF<br/>[FR] HYDROGENATION CATALYTIQUE DE NITRILES POUR PRODUIRE DES DERIVES CAPSAICINOIDES ET DES COMPOSES D'AMINES, ET PROCEDES DE PURIFICATION ET D'OBTENTION DE LEURS POLYMORPHES
  申请人：STIEFEL LABORATORIES

  公开号：WO2005068414A1

  公开（公告）日：2005-07-28

  Processes for preparing an amine compound by catalytically hydrogenating a precursor nitrile compound. In a particular aspect, the present hydrogenation process occurs in a dipolar organic solvent in the presence of a palladium/carbon catalyst and a strong anhydrous protic acid. In a further aspect, the preferred embodiment relates to a process for deprotecting a compound to produce an amine compound. In yet a further aspect, the preferred embodiment relates to amine products produced by the present processes. These amine products may be used for a variety of purposes.

  通过在存在钯/碳催化剂和强无水质子酸的情况下，在偶极有机溶剂中催化氢化前体腈化合物的过程。在一个特定方面，目前的氢化过程发生在一个偶极有机溶剂中，在钯/碳催化剂和强无水质子酸的存在下。在另一个方面，首选实施例涉及一种去保护化合物以产生胺化合物的过程。在另一个方面，首选实施例涉及通过目前的过程产生的胺产品。这些胺产品可以用于各种目的。
• AMINOETHYLATION PROCESS HAVING IMPROVED YIELD OF ARYLOXYALKYLENE AMINE COMPOUNDS AND REDUCED UREA BY-PRODUCTS
  申请人：McDougall Patrick J.

  公开号：US20140073814A1

  公开（公告）日：2014-03-13

  Disclosed is a process for preparing an aryloxyalkylene amine compound via an aminoethylation reaction comprising: a) reacting an aromatic hydroxyl compound in the presence of a basic catalyst with a 2-oxazolidinone compound of the formula II to form an intermediate reaction product; wherein R 3 is selected from the group consisting of hydrogen or lower alkyl having 1 to 6 carbon atoms, R 4 is selected from the group consisting of hydrogen, straight or branched chain alkyl having from one to six carbon atoms, phenyl, alkaryl, or arylalkyl; and b) reacting the intermediate product of step a) with a polyalkylene polyamine.

  揭示了一种通过氨基乙基化反应制备芳基氧基烷胺化合物的过程，包括：a)在碱性催化剂存在下，将芳香羟基化合物与式II的2-噁唑烷酮化合物反应，形成中间反应产物；其中R3选自氢或1至6个碳原子的较低烷基，R4选自氢、一元或分支链烷基（含1至6个碳原子）、苯基、烷基芳基或芳基烷基；b)将步骤a）中间产物与聚烷基聚胺反应。
• Carbamic acid derivatives
  申请人：Hoffmann-La Roche Inc.

  公开号：US04215139A1

  公开（公告）日：1980-07-29

  Carbamic acid derivatives, processes for their preparation, as well as pesticidal compositions containing the carbamic acid derivatives, and methods for their use, are disclosed.

  本发明揭示了羧酸衍生物，其制备过程，以及含有该羧酸衍生物的杀虫剂组合物和使用方法。
• Catalytic hydrogenation of nitriles to produce capsaicinoid derivatives and amine compounds, and methods for purifying and obtaining the polymorphs thereof
  申请人：Meckler Harold

  公开号：US20060047171A1

  公开（公告）日：2006-03-02

  Processes for preparing an amine compound by catalytically hydrogenating a precursor nitrile compound. In a particular aspect, the present hydrogenation process occurs in a dipolar organic solvent in the presence of a palladium/carbon catalyst and a strong anhydrous protic acid. In a further aspect, the preferred embodiment relates to a process for deprotecting a compound to produce an amine compound. In yet a further aspect, the preferred embodiment relates to amine products produced by the present processes. These amine products may be used for a variety of purposes.

  通过催化氢化前体腈化合物制备胺化合物的过程。在特定方面，本氢化过程发生在极性有机溶剂中，在钯/碳催化剂和强无水质子酸的存在下。在进一步方面，首选实施例涉及去保护化合物以产生胺化合物的过程。在另一个进一步方面，首选实施例涉及由本过程产生的胺产品。这些胺产品可用于各种用途。