1-(2-羟基-4-甲氧基苯基)-3-(3-羟基苯基)丙-2-烯-1-酮 | 32274-69-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 中文名称: 1-(2-羟基-4-甲氧基苯基)-3-(3-羟基苯基)丙-2-烯-1-酮
• 英文名称: 2',3-dihydroxy-4'-methoxychalcone
• 英文别名: trans-2',3-Dihydroxy-4'-methoxychalcone；1-(2-hydroxy-4-methoxyphenyl)-3-(3-hydroxyphenyl)prop-2-en-1-one
• CAS: 32274-69-4
• 化学式: C₁₆H₁₄O₄
• 分子量: 270.285
• InChiKey: REZLOMBHXVOHSX-UHFFFAOYSA-N

物化性质

• 沸点：
  522.1±50.0 °C(Predicted)
• 密度：
  1.282±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2914509090

反应信息

• 作为反应物：
  描述：

  1-(2-羟基-4-甲氧基苯基)-3-(3-羟基苯基)丙-2-烯-1-酮 、 4-磺酰胺基苯肼盐酸盐 以 乙醇 为溶剂， 以60%的产率得到4-[5-(2-Hydroxy-4-methoxyphenyl)-3-(3-hydroxyphenyl)-3,4-dihydropyrazol-2-yl]benzenesulfonamide
  参考文献：
  名称：

  Synthesis and antiinflammatory activity of some new 1,3,5-trisubstituted pyrazolines bearing benzene sulfonamide

  摘要：

  Nineteen new 2-pyrazoline bearing benzenesulfonamide derivatives were synthesized by condensing chalcones with 4-hydrazinonbenzenesulfonamide hydrochloride. Their chemical structures were proved by means of IR, H-1 NMR, C-13 NMR, mass spectroscopic and elemental analyses data. These compounds were tested at dose of 20 mg/kg for their anti-inflammatory activity in carrageenan-induced rat paw edema model and volume of paw edema was measured at 0, 3 and 5 h. Two compounds 3k and 3l were found to be more active than celecoxib throughout the study (at 3 and 5 h). While two other compounds 3m and 3n showed more potent activity than celecoxib at 5 h. They are devoid of ulcerogenic potential when administered orally at a dose of 60 mg/kg. Compounds (3k-m) showed COX-1 and COX-2 inhibitory activity at 0.05 mu M. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.10.105
• 作为产物：
  描述：

  丹皮酚 、 间羟基苯甲醛 以 乙醇 为溶剂， 生成 1-(2-羟基-4-甲氧基苯基)-3-(3-羟基苯基)丙-2-烯-1-酮
  参考文献：
  名称：

  Synthesis and antiinflammatory activity of some new 1,3,5-trisubstituted pyrazolines bearing benzene sulfonamide

  摘要：

  Nineteen new 2-pyrazoline bearing benzenesulfonamide derivatives were synthesized by condensing chalcones with 4-hydrazinonbenzenesulfonamide hydrochloride. Their chemical structures were proved by means of IR, H-1 NMR, C-13 NMR, mass spectroscopic and elemental analyses data. These compounds were tested at dose of 20 mg/kg for their anti-inflammatory activity in carrageenan-induced rat paw edema model and volume of paw edema was measured at 0, 3 and 5 h. Two compounds 3k and 3l were found to be more active than celecoxib throughout the study (at 3 and 5 h). While two other compounds 3m and 3n showed more potent activity than celecoxib at 5 h. They are devoid of ulcerogenic potential when administered orally at a dose of 60 mg/kg. Compounds (3k-m) showed COX-1 and COX-2 inhibitory activity at 0.05 mu M. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.10.105

文献信息

• NOTCH INHIBITORS FOR USE IN THE TREATMENT OF T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
  申请人：UNIVERSITÀ DEGLI STUDI DI ROMA "LA SAPIENZA"

  公开号：US20190337916A1

  公开（公告）日：2019-11-07

  Compounds of formula (I) in the capacity of compounds with anti-tumor activity for the treatment of T-cell acute lymphoblastic leukemia (T-ALL).
• Synthesis and antiinflammatory activity of some new 1,3,5-trisubstituted pyrazolines bearing benzene sulfonamide
  作者：I.G. Rathish、Kalim Javed、Shamim Ahmad、Sameena Bano、M.S. Alam、K.K. Pillai、Surender Singh、Vivek Bagchi

  DOI：10.1016/j.bmcl.2008.10.105

  日期：2009.1

  Nineteen new 2-pyrazoline bearing benzenesulfonamide derivatives were synthesized by condensing chalcones with 4-hydrazinonbenzenesulfonamide hydrochloride. Their chemical structures were proved by means of IR, H-1 NMR, C-13 NMR, mass spectroscopic and elemental analyses data. These compounds were tested at dose of 20 mg/kg for their anti-inflammatory activity in carrageenan-induced rat paw edema model and volume of paw edema was measured at 0, 3 and 5 h. Two compounds 3k and 3l were found to be more active than celecoxib throughout the study (at 3 and 5 h). While two other compounds 3m and 3n showed more potent activity than celecoxib at 5 h. They are devoid of ulcerogenic potential when administered orally at a dose of 60 mg/kg. Compounds (3k-m) showed COX-1 and COX-2 inhibitory activity at 0.05 mu M. (C) 2008 Elsevier Ltd. All rights reserved.