1-(3,4,5-三羟苯基)-1-壬酮 | 100079-26-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-(3,4,5-三羟苯基)-1-壬酮
• 英文名称: 1-(3,4,5-Trihydroxyphenyl)nonan-1-one
• CAS: 100079-26-3
• 化学式: C₁₅H₂₂O₄
• 分子量: 266.33
• InChiKey: NVFRHTFJDGAFQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• TREATMENT OF PAIN BY TARGETING NR4A1
  申请人：University of Cincinnati

  公开号：EP4103216A1

  公开（公告）日：2022-12-21
• [EN] TREATMENT OF PAIN BY TARGETING NR4A1<br/>[FR] TRAITEMENT DE LA DOULEUR PAR CIBLAGE DE NR4A1
  申请人：UNIV CINCINNATI

  公开号：WO2021042038A1

  公开（公告）日：2021-03-04

  The present invention involves a method of treating pain. The method treats a patient having post-operative pain or chemotherapy induced neuropathic pain, and it involves a) assessing the patient to determine if they are experiencing post-operative pain or chemotherapy induced neuropathic pain, and if such pain is diagnosed; b) administering to the patient a therapeutically effective amount of an agonist for the nuclear receptor subfamily 4, group A, member 1 (NR4A1). In one embodiment, the agonist is selected from the group consisting of Cytosporone B, Ethyl 2-[2,3,4-trimethoxy-6-(1-octanoyl)-phenyl] acetate (TMPA), 1,3,7-trihydroxy-2,4-diprenylxanthone (CCE9), 1-(3,4,5-trihydroxyphenyl)-nonan-1-one (THPN), DIM-C-pPhOCH3 (C-DIM-5), 1,1-bis(3 '-indolyl)-1-(phenyl)methane (DIM-C-Ph) and 1,1-bis(3 '-indolyl)-1-(p-anisyl)methane (DIM-C-pPhOCH3).
• [EN] METFORMIN PREVENTS HYPERGLYCAEMIA-ASSOCIATED, OXIDATIVE STRESS-INDUCED VASCULAR ENDOTHELIAL DYSFUNCTION: ESSENTIAL ROLE FOR THE ORPHAN NUCLEAR RECEPTOR, NR4A1 (NUR77)<br/>[FR] LA METFORMINE PRÉVIENT UN DYSFONCTIONNEMENT ENDOTHÉLIAL VASCULAIRE INDUIT PAR LE STRESS OXYDATIF ASSOCIÉ À L'HYPERGLYCÉMIE : RÔLE ESSENTIEL POUR LE RÉCEPTEUR NUCLÉAIRE ORPHELIN, NR4A1 (NUR77)
  申请人：[en]UTI LIMITED PARTNERSHIP

  公开号：WO2022133586A1

  公开（公告）日：2022-06-30

  Metformin prevents hyperglycaemia-associated, oxidative stress-induced vascular endothelial dysfunction at low concentrations (~1 µM). The orphan nuclear receptor Nr4al (i.e. Nur77) is involved in the protective activity, which can be reversed by a Na4rl antagonist.