1-(4-氨基苄基硫代)-beta-d-吡喃葡萄糖 | 35785-20-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-(4-氨基苄基硫代)-beta-d-吡喃葡萄糖
• 中文别名: 4-氨基苄基B-D-硫代吡喃半乳糖苷
• 英文名称: 1-(4-Aminobenzylthio)-beta-D galactopyranose
• 英文别名: (2S,3R,4S,5R,6R)-2-[(4-aminophenyl)methylsulfanyl]-6-(hydroxymethyl)oxane-3,4,5-triol
• CAS: 35785-20-7
• 化学式: C₁₃H₁₉NO₅S
• mdl: MFCD00057540
• 分子量: 301.36
• InChiKey: VNOKYKUWHBAQKG-SJHCENCUSA-N

物化性质

• 熔点：
  211-215
• 沸点：
  579.2±50.0 °C(Predicted)
• 密度：
  1.48±0.1 g/cm3(Predicted)
• 溶解度：
  略微加热可溶于甲醇及水

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.538
• 拓扑面积：
  142
• 氢给体数：
  5
• 氢受体数：
  7

安全信息

• 危险品标志：
  Xi

文献信息

• Activity-dependent neurotrophic factor III (ADNF III)
  申请人：THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

  公开号：EP2172478A2

  公开（公告）日：2010-04-07

  The present invention relates generally to Activity Dependent Neurotrophic Factor III (ADNF III), also known as Activity Dependent Neuroprotective Protein (ADNP). More particularly, the present invention relates to nucleic acid sequences encoding ADNF III polypeptides; ADNF III polypeptides encoded by such nuclei acid sequences; antibodies to ADNF III polypeptides; and methods of using such ADNF III polypeptides for the treatment of neurological deficiencies and for the prevention of cell death associated with (1) gp 120, the envelope protein from HIV; (2) N-methyl-D-aspartic acid (excito-toxicity); (3) tetrodotoxin (blockage of electrical activity); and (4) β-amyloid peptide, a substance related to neuronal degeneration in Alzheimer's disease.

  本发明一般涉及活动依赖性神经营养因子 III（ADNF III），也称为活动依赖性神经保护蛋白（ADNP）。更具体地说，本发明涉及编码 ADNF III 多肽的核酸序列；由此类核酸序列编码的 ADNF III 多肽；ADNF III 多肽的抗体；以及使用这种 ADNF III 多肽治疗神经系统缺陷和预防细胞死亡的方法，这些神经系统缺陷和细胞死亡与以下物质有关：(1)gp 120，HIV 的包膜蛋白；(2)N-甲基-D-天冬氨酸（兴奋毒性）；(3)河豚毒素（电活动阻断）；以及(4)β-淀粉样肽，一种与阿尔茨海默氏症中神经元变性有关的物质。
• Activity dependent neurotrophic factor III (ADNF III)
  申请人：The Government of the USA as Represented by the Secretary of the Dept. of Health & Human Services

  公开号：US20040053313A1

  公开（公告）日：2004-03-18

  The present invention relates generally to Activity Dependent Neurotrophic Factor III (ADNF III), also known as Activity Dependent Neuroprotective Protein (ADNP). More particularly, the present invention relates to nucleic acid sequences encoding ADNF III polypeptides; ADNF III polypeptides encoded by such nucleic acid sequences; antibodies to ADNF III polypeptides; and methods of using such ADNF III polypeptides for the treatment of neurological deficiencies and for the prevention of cell death associated with (1) gp120, the envelope protein from HIV; (2) N-methyl-D-aspartic acid (excito-toxicity); (3) tetrodotoxin (blockage of electrical activity); and (4) &bgr;-amyloid peptide, a substance related to neuronal degeneration in Alzheimer's disease.

  本发明一般涉及活动依赖性神经营养因子 III（ADNF III），也称为活动依赖性神经保护蛋白（ADNP）。更具体地说，本发明涉及编码 ADNF III 多肽的核酸序列；由此类核酸序列编码的 ADNF III 多肽；ADNF III 多肽的抗体；以及使用这种ADNF III多肽治疗神经系统缺陷和预防细胞死亡的方法，这些神经系统缺陷和细胞死亡与以下物质有关：(1)gp120，HIV的包膜蛋白；(2)N-甲基-D-天冬氨酸（兴奋毒性）；(3)河豚毒素（电活动阻断）；以及(4)&bgr;-淀粉样肽，一种与阿尔茨海默氏症中神经元变性有关的物质。
• Verfahren zum Nachweis von Substanzen mit Hydrolaseaktivität
  申请人：BOEHRINGER MANNHEIM GMBH

  公开号：EP0350808B1

  公开（公告）日：1995-11-08
• Hydrolase-Substrate
  申请人：BOEHRINGER MANNHEIM GMBH

  公开号：EP0423632B1

  公开（公告）日：1995-08-16
• METHOD AND COMPOSITION FOR DETECTING BACTERIAL CONTAMINATION IN FOOD PRODUCTS
  申请人：BioControl Systems, Inc.

  公开号：EP0870054B1

  公开（公告）日：2008-07-30