1-(呋喃-2-基)-2-(4-甲氧基苯基)乙酮 | 81474-54-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1-(呋喃-2-基)-2-(4-甲氧基苯基)乙酮
• 英文名称: 1-(furan-2-yl)-2-(4-methoxyphenyl)ethanone
• 英文别名: 2-(p-methoxyphenyl)-acetylfuran；1-(2-Furyl)-2-(4-methoxyphenyl)-ethanone；1-(Furan-2-yl)-2-(4-methoxyphenyl)ethan-1-one
• CAS: 81474-54-6
• 化学式: C₁₃H₁₂O₃
• 分子量: 216.236
• InChiKey: KAPQFLKYRYKTBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  39.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(呋喃-2-基)-2-(4-甲氧基苯基)乙酮 在 A-162 Br₃^1- 作用下， 以 硝基甲烷 为溶剂， 反应 4.0h， 以90%的产率得到2-Chloro-1-furan-2-yl-2-(4-methoxy-phenyl)-ethanone
  参考文献：
  名称：

  One Pot Synthesis of Furyl α-Bromoketones from Furyl Ketones Using the A-162 Br3-Resin/CH3NO2 System

  摘要：

  Furyl ketones are brominated in a single - step reaction using the A-162 Br3/CH3NO2 system Furyl alpha-bromoketones are obtained with good yield and high selectivity .

  DOI：

  10.1080/00397919208021322
• 作为产物：
  描述：

  对甲氧基苯基丙酮 在 2-mesityl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate 、 2,4,5,6-四(9H-咔唑-9-基)异酞腈 、 碘 、 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 48.0h， 生成 1-(呋喃-2-基)-2-(4-甲氧基苯基)乙酮
  参考文献：
  名称：

  酮的同系化：通过光氧化还原催化脱酰-芳酰化序列将烷基酮直接转化为芳基酮

  摘要：

  酮作为重要的官能团骨架，由于其多样化的转变而引起了人们的极大兴趣。在这里，我们描述了一种多功能的光氧化还原催化的脱酰化-芳酰化策略，该策略能够将烷基酮直接转化为芳基酮。该过程涉及由烷基酮衍生的二氢喹唑啉酮的光氧化还原脱酰作用以产生烷基自由基，随后进行 NHC 催化或 NHC 介导的自由基芳酰化。

  DOI：

  10.1021/acs.orglett.4c02576

文献信息

• 1,2,3-thiadiazole compounds, compositions and method of anti-thrombotic
  申请人：The Upjohn Company

  公开号：US05098918A1

  公开（公告）日：1992-03-24

  Novel 1,2,3-thiadiazole compounds, new and old 1,2,3-thiadiazole compositions and method of anti-thrombotic treatment are systemically administered to a human or animal.

  新颖和旧的1,2,3-噻二唑化合物，新的和旧的1,2,3-噻二唑组合物以及抗血栓治疗方法被系统地用于人类或动物。
• Iridium‐Catalyzed Asymmetric Hydrogenation of <i>N</i> ‐Alkyl α‐Aryl Furan‐Containing Imines: an Efficient Route to Unnatural <i>N</i> ‐Alkyl Arylalanines and Related Derivatives.
  作者：Javier Mazuela、Thomas Antonsson、Laurent Knerr、Stephen P. Marsden、Rachel H. Munday、Magnus J. Johansson

  DOI：10.1002/adsc.201801143

  日期：2019.2

  High throughput experimentation (HTE) has enabled the rapid identification of ligand/precatalyst combinations that facilitate highly enantioselective hydrogenations of prochiral N‐alkyl α‐aryl ketimines containing a furyl moiety. The chiral amines obtained have proven to be modular precursors in the synthesis of unnatural mono N‐alkylated arylalanines and related derivatives.

  高通量实验（HTE）已使快速鉴定配体/预催化剂组合成为可能，从而促进了含有呋喃基部分的前手性N-烷基α-芳基酮亚胺的高度对映选择性氢化。已证明所获得的手性胺是合成非天然单N烷基化芳基丙氨酸和相关衍生物的模块前体。
• A spiro-bis-γ-lactone glucoside from viburnum dilatatum
  作者：Tetsuo Iwagawa、Tsunao Hase

  DOI：10.1016/s0031-9422(00)80539-7

  日期：1984.1

  Abstract A new spiro-bis-γ-lactone glucoside was isolated from the leaves of Viburnum dilatatum and its structure was elucidated on the basis of spectral and chemical evidence.

  摘要 从荚膜荚兰(Viburnum dilatatum) 的叶子中分离到了一种新的螺双-γ-内酯糖苷，并根据光谱和化学证据阐明了其结构。
• Synthesis and platelet aggregation inhibitory activity of 4,5-bis(substituted)-1,2,3-thiadiazoles
  作者：Edward W. Thomas、Edward E. Nishizawa、David C. Zimmermann、Davey J. Williams

  DOI：10.1021/jm00382a009

  日期：1985.4

  Routine screening of compounds for inhibition of collagen-induced platelet aggregation in vitro revealed 4,5-bis-(4-methoxyphenyl)-1,2,3-thiadiazole (2) was active and it represents the first example of a 1,2,3-thiadiazole with possible antithrombotic activity. In order to develop a structure-activity relationship for this heterocycle, a number of new 4(5)-mono- and -disubstituted 1,2,3-thiadiazoles were synthesized. These were tested in our screen and a number of additional active compounds were found. The most active compounds (2, 5a, 5b, and 6c) were those in which the heterocycle was substituted with benzene rings possessing para electron-donating groups.
• THOMAS, E. W.;NISHIZAWA, E. E.;ZIMMERMANN, D. C.;WILLIAMS, D. J., J. MED. CHEM., 1985, 28, N 4, 442-446
  作者：THOMAS, E. W.、NISHIZAWA, E. E.、ZIMMERMANN, D. C.、WILLIAMS, D. J.

  DOI：——

  日期：——