1-(溴甲基)-3,5-二氟-2-甲氧基苯 | 52510-51-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-(溴甲基)-3,5-二氟-2-甲氧基苯
• 英文名称: [(2R,3R,4R,5R)-5-acetamido-2,4-dihydroxy-6-oxo-1-sulfooxyhexan-3-yl] hydrogen sulfate
• CAS: 52510-51-7
• 化学式: C₈H₁₅NO₁₂S₂
• 分子量: 381.3
• InChiKey: JDJXXRJSUJZYDJ-OSMVPFSASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.2
• 重原子数：
  23
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  231
• 氢给体数：
  5
• 氢受体数：
  12

文献信息

• Oligosaccharide biomarkers for mucopolysaccharidoses and other related disorders
  申请人：Meikle John Peter

  公开号：US20060286034A1

  公开（公告）日：2006-12-21

  The present invention is related to methods for diagnosing mucopolysaccharidoses (“MPS”) and related diseases. This invention pertains to methods for identifying and quantitating biochemical markers (“biomarkers”) that are present in biological fluids or tissues of a patient having a MPS or related disorder. One aspect of the method comprises determining a target quantity of a target MPS biomarker oligosaccharide from a target biological sample taken from the target animal, and then comparing the target quantity to a reference quantity of a reference MPS biomarker oligosaccharide for the diagnosis, characterization, monitoring, and clinical management of MPS and related disease. This invention also describes a kit comprising a oligosaccharide derivatization solution; an acid solution; an internal standard; a solid phase extraction column; a solid phase extraction column wash solution; an oligosaccharide elution solution; and a set of instructions for using the kit to diagnose a MPS or related disease.

  本发明涉及诊断粘多糖病（“MPS”）及相关疾病的方法。本发明涉及一种用于识别和定量生物标志物（“生物标记物”）的方法，这些生物标记物存在于患有MPS或相关疾病的患者的生物体液或组织中。该方法的一个方面包括确定来自目标生物样本的目标动物的目标MPS生物标记物寡糖的目标量，然后将目标量与用于诊断、表征、监测和临床管理MPS和相关疾病的参考MPS生物标记物寡糖的参考量进行比较。本发明还描述了一种工具包，包括寡糖衍生物溶液；酸溶液；内部标准；固相萃取柱；固相萃取柱洗涤溶液；寡糖洗脱溶液；以及一套用于使用该工具包诊断MPS或相关疾病的说明书。
• Biomedical materials
  申请人：Nishihara, Katsunari

  公开号：EP0842670A1

  公开（公告）日：1998-05-20

  The present invention provides a biomedical material comprising a shark-derived collagen; a biomedical material comprising a shark-derived collagen and hydroxyapatite; and methods for preparing the same. Since the biomedical materials of the invention comprise a shark-derived collagen which is low in antigenicity and high in biocompatibility, they do not cause rejection and they produce effects of good adhesion to organisms and easy remodeling when they are used as artificial skin, artificial tendon, artificial bone, surgical suture or the like. They also have an effect that they do not leave a prominent scar when the wound has been cured. Further, the biomedical materials of the invention are excellent in mechanical strength. Thus, when used as artificial skin, they are hard to tear, good for tightly adhering and capable of following the movement of a joint well.

  本发明提供了一种由鲨鱼源胶原组成的生物医学材料；一种由鲨鱼源胶原和羟基磷灰石组成的生物医学材料；以及制备方法。由于本发明的生物医学材料包含一种抗原性低、生物相容性高的鲨鱼源胶原蛋白，因此在用作人造皮肤、人造肌腱、人造骨骼、手术缝合线或类似材料时，不会产生排异反应，并能产生良好的生物粘附性和易于重塑的效果。它们还具有伤口愈合后不会留下明显疤痕的效果。此外，本发明的生物医学材料具有优异的机械强度。因此，当用作人造皮肤时，它们不易撕裂，粘合紧密，并能很好地跟随关节运动。
• OLIGOSACCHARIDES OF DERMATAN SULPHATE, PROCESS FOR THEIR PRODUCTION, AND ASSOCIATED PHARMACEUTICAL COMPOSITIONS
  申请人：OPOCRIN S.p.A.

  公开号：EP0600934B1

  公开（公告）日：1997-03-19
• EP1532438A4
  申请人：——

  公开号：EP1532438A4

  公开（公告）日：2006-12-06
• OLIGOSACCHARIDE BIOMARKERS FOR MUCOPOLYSACCHARIDOSES AND OTHER RELATED DISORDERS
  申请人：WOMEN'S AND CHILDREN'S HOSPITAL

  公开号：EP1532438A1

  公开（公告）日：2005-05-25