4,5-dichloro-2-(2-(4-methoxyphenyl)-2-oxoethyl)pyridazin-3(2H)-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4,5-dichloro-2-(2-(4-methoxyphenyl)-2-oxoethyl)pyridazin-3(2H)-one
• 英文别名: 4,5-Dichloro-2-[2-(4-methoxyphenyl)-2-oxoethyl]pyridazin-3-one
• 化学式: C₁₃H₁₀Cl₂N₂O₃
• 分子量: 313.14
• InChiKey: GRTQUDDXRUDZIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  59
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] PYRIDAZINONES FOR THE TREATMENT OR PREVENTION OF HYPERTENSION<br/>[FR] PYRIDAZINONES POUR LE TRAITEMENT OU LA PRÉVENTION DE L'HYPERTENSION
  申请人：[en]UNIVERSITETET I OSLO

  公开号：WO2022258992A1

  公开（公告）日：2022-12-15

  The invention provides compounds of formula (I), stereoisomers, and pharmaceutically acceptable salts thereof for use in the treatment or prevention of hypertension: wherein: R1 and R2 are independently selected from H, halogen, C1-6alkyl, C1-6haloalkyl, and -CN, provided that at least one of R1and R2is other than H; and R3is a group of the formula: wherein: n is 0 or 1; R4is H or C1-3alkyl; L1is a linking group selected from a bond, -(CH2)P- in which p is an integer from 1 to 3, and C3-6cycloalkylene; and X is selected from: (i) an aryl group optionally substituted by one or more substituents selected from C1-3alkyl, C1-3alkoxy, C1-3haloalkyl, halogen, and -CN; (ii) a 5 or 6- membered heterocyclic ring optionally substituted by one or more substituents selected from C1-3alkyl, C1-3alkoxy, C1-3haloalkyl, halogen, and optionally substituted phenyl; and (iii) a cycloalkyl group optionally substituted by one or more substituents selected from C1-3alkyl, C1-3haloalkyl, and halogen.