1-[2-(十六烷氧基)乙氧基]十六烷 | 17367-09-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-[2-(十六烷氧基)乙氧基]十六烷
• 英文名称: Ethylenglycol-bis-hexadecylether
• 英文别名: Glycol-di-cetylether；1,2-bis-hexadecyloxy-ethane；1,2-Bis-hexadecyloxy-aethan；Ethane, 1,2-bis(hexadecyloxy)-；1-(2-hexadecoxyethoxy)hexadecane
• CAS: 17367-09-8
• 化学式: C₃₄H₇₀O₂
• 分子量: 510.929
• InChiKey: VONSQKWGDMKGDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  15.4
• 重原子数：
  36
• 可旋转键数：
  33
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2909199090

反应信息

• 作为产物：
  描述：

  1-chloromethoxy-hexadecane 在 铜 作用下， 生成 1-[2-(十六烷氧基)乙氧基]十六烷
  参考文献：
  名称：

  Teramura; Oda, Kogyo Kagaku zasshi / Journal of the Society of Chemical Industry, 1951, vol. 54, p. 604,606

  摘要：

  DOI：

文献信息

• Novel Lipids and Compositions for Intracellular Delivery of Biologically Active Compounds
  申请人：Constien Rainer

  公开号：US20120295832A1

  公开（公告）日：2012-11-22

  The present invention provides novel amino-lipids, compositions comprising such amino-lipids and methods of producing them. In addition, lipid nanoparticles comprising the novel amino-lipids and a biologically active compound are provided, as well as methods of production and their use for intracellular drug delivery.

  本发明提供了新型氨基脂质、含有这种氨基脂质的组合物以及它们的制备方法。此外，还提供了包含新型氨基脂质和生物活性化合物的脂质纳米粒子，以及它们的制备方法和用于细胞内药物输送的方法。
• Amphoteric liposomes, a method of formulating an amphoteric liposome and a method of loading an amphoteric liposome
  申请人：Panzner Steffen

  公开号：US20080089932A1

  公开（公告）日：2008-04-17

  An amphoteric liposome composed of a mixture of lipids, said mixture comprising a cationic amphiphile, an anionic amphiphile and optionally one or more neutral amphiphiles, at least one of said cationic and anionic amphiphiles being chargeable and the respective amounts of said cationic and anionic amphiphiles being selected such there is a stoichiometric excess of positively charged cationic amphiphile at a first lower pH, a stoichiometric excess of negatively charged anionic amphiphile at a second higher pH and said mixture has an isoelectric point intermediate said first and second pHs; characterised in that said positively charged cationic and negatively charged anionic amphiphiles are adapted to form a lipid salt with one another at said isoelectric point. Also disclosed are methods of predicting the fusogenicity of an amphoteric liposome at a given pH, formulating an amphoteric liposome and loading an amphoteric liposome with a cargo moiety.

  一种由混合脂质组成的两性脂质体，所述混合物包括阳离子型两性分子、阴离子型两性分子和可选的一种或多种中性两性分子，其中至少一种阳离子型和阴离子型两性分子可被电荷化，所述阳离子型和阴离子型两性分子的相应量被选择为在第一个较低的pH下具有过量的正电荷的阳离子型两性分子，在第二个较高的pH下具有过量的负电荷的阴离子型两性分子，且所述混合物具有介于第一个和第二个pH之间的等电点；其特征在于所述的阳离子型和阴离子型两性分子适合在所述等电点处彼此形成脂质盐。还公开了预测给定pH下两性脂质体的融合性、制备两性脂质体和将载荷基团装载到两性脂质体中的方法。
• Amphoteric Liposomes, A Method Of Formulating An Amphoteric Liposome And A Method Of Loading An Amphoteric Liposome
  申请人：Panzner Steffen

  公开号：US20120135065A1

  公开（公告）日：2012-05-31

  An amphoteric liposome composed of a mixture of lipids, said mixture comprising a cationic amphiphile, an anionic amphiphile and optionally one or more neutral amphiphiles, at least one of said cationic and anionic amphiphiles being chargeable and the respective amounts of said cationic and anionic amphiphiles being selected such there is a stoichiometric excess of positively charged cationic amphiphile at a first lower pH, a stoichiometric excess of negatively charged anionic amphiphile at a second higher pH and said mixture has an isoelectric point intermediate said first and second pHs; characterised in that said positively charged cationic and negatively charged anionic amphiphiles are adapted to form a lipid salt with one another at said isoelectric point. Also disclosed are methods of predicting the fusogenicity of an amphoteric liposome at a given pH, formulating an amphoteric liposome and loading an amphoteric liposome with a cargo moiety.

  一种两性脂质体，由混合脂质组成，所述混合物包括阳离子两性分子、阴离子两性分子和可选的一个或多个中性两性分子，其中至少一种阳离子和阴离子两性分子是可带电的，并且所述阳离子和阴离子两性分子的相应量被选择为在第一个较低的pH值下存在过量的带正电荷的阳离子两性分子，在第二个较高的pH值下存在过量的带负电荷的阴离子两性分子，并且所述混合物具有介于第一个和第二个pH值之间的等电点；其特征在于所述带正电荷的阳离子和带负电荷的阴离子两性分子被适应在所述等电点处彼此形成脂质盐。还公开了预测在给定pH下两性脂质体的融合性、制备两性脂质体和将载荷基团装载到两性脂质体中的方法。
• AMPHOTERIC LIPOSOME FORMULATIONS
  申请人：Marina Biotech, Inc.

  公开号：US20160151282A1

  公开（公告）日：2016-06-02

  An amphoteric liposome composed of a mixture of lipids, said mixture comprising a cationic amphiphile, an anionic amphiphile and optionally one or more neutral amphiphiles, at least one of said cationic and anionic amphiphiles being chargeable and the respective amounts of said cationic and anionic amphiphiles being selected such there is a stoichiometric excess of positively charged cationic amphiphile at a first lower pH, a stoichiometric excess of negatively charged anionic amphiphile at a second higher pH and said mixture has an isoelectric point intermediate said first and second pHs; characterised in that said positively charged cationic and negatively charged anionic amphiphiles are adapted to form a lipid salt with one another at said isoelectric point. Also disclosed are methods of predicting the fusogenicity of an amphoteric liposome at a given pH, formulating an amphoteric liposome and loading an amphoteric liposome with a cargo moiety.

  由混合脂质组成的两性脂质体，所述混合物包括阳离子两性分子、阴离子两性分子和可选的一种或多种中性两性分子，其中至少一种阳离子和阴离子两性分子可被带电，并且所述阳离子和阴离子两性分子的相应量被选择为在第一个较低pH下存在过量的带正电的阳离子两性分子，在第二个较高pH下存在过量的带负电的阴离子两性分子，并且所述混合物具有介于第一个和第二个pH之间的等电点；其特征在于所述带正电的阳离子和带负电的阴离子两性分子被适应在所述等电点处彼此形成脂质盐。还公开了预测给定pH下两性脂质体的融合性、制备两性脂质体和将载荷基团装载到两性脂质体中的方法。
• Amphoteric liposomes, method of formulating an amphoteric liposome and a method of loading an amphoteric liposome
  申请人：novosom AG

  公开号：EP1911443A1

  公开（公告）日：2008-04-16

  An amphoteric liposome composed of a mixture of lipids, said mixture comprising a cationic amphiphile, an anionic amphiphile and optionally one or more neutral amphiphiles, at least one of said cationic and anionic amphiphiles being chargeable and the respective amounts of said cationic and anionic amphiphiles being selected such there is a stoichiometric excess of positively charged cationic amphiphile at a first lower pH, a stoichiometric excess of negatively charged anionic amphiphile at a second higher pH and said mixture has an isoelectric point intermediate said first and second pHs; characterised in that said positively charged cationic and negatively charged anionic amphiphiles are adapted to form a lipid salt with one another at said isoelectric point. Also disclosed are methods of predicting the fusogenicity of an amphoteric liposome at a given pH, formulating an amphoteric liposome and loading an amphoteric liposome with a cargo moiety.

  一种两性脂质体，由脂质混合物组成，所述混合物包括阳离子两性化合物、阴离子两性化合物和一种或多种中性两性化合物、所述阳离子和阴离子双亲化合物中至少有一种是可带电的，且阳离子和阴离子双亲化合物各自的量应选择为：在第一个较低的 pH 值下，带正电的阳离子双亲化合物按比例过量，在第二个较高的 pH 值下，带负电的阴离子双亲化合物按比例过量，且所述混合物的等电点介于所述第一和第二 pH 值之间；其特征在于，所述带正电荷的阳离子和带负电荷的阴离子两性化合物可在所述等电点相互形成脂盐。还公开了预测两性脂质体在给定 pH 值下的溶融性、配制两性脂质体和用货物分子装载两性脂质体的方法。