1-[3-(3-甲氧基丙氧基)丙氧基]丁烷 | 106002-01-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-[3-(3-甲氧基丙氧基)丙氧基]丁烷
• 英文名称: 1-<3-(3-Methoxypropoxy)propoxy>butan
• 英文别名: 1-[3-(3-Methoxypropoxy)propoxy]butane
• CAS: 106002-01-1
• 化学式: C₁₁H₂₄O₃
• 分子量: 204.31
• InChiKey: FTVFUKMOMFUYAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-溴-3-甲氧基丙烷 、 Kalium-3-butoxypropanolat 生成 1-[3-(3-甲氧基丙氧基)丙氧基]丁烷
  参考文献：
  名称：

  Kirmse, Wolfgang; Jansen, Ulrich, Chemische Berichte, 1985, vol. 118, # 7, p. 2607 - 2625

  摘要：

  DOI：

文献信息

• [EN] CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE<br/>[FR] COMPOSÉS ANTISENS CONJUGUÉS ET LEUR UTILISATION
  申请人：ISIS PHARMACEUTICALS INC

  公开号：WO2015179693A1

  公开（公告）日：2015-11-26

  Provided herein are oligomeric compounds with conjugate groups. In certain embodiments, the gomeric compounds are conjugated to N-Acetylgalactosamine or to N-Acetylgalactosamine analogues.

  本文提供了具有共轭基团的寡聚化合物。在某些实施例中，这些寡聚化合物与N-乙酰半乳糖或N-乙酰半乳糖类似物结合。
• KIRMSE, W.;JANSEN, U., CHEM. BER., 1985, 118, N 7, 2607-2625
  作者：KIRMSE, W.、JANSEN, U.

  DOI：——

  日期：——
• US20140343123A1
  申请人：——

  公开号：US20140343123A1

  公开（公告）日：2014-11-20
• COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN C-III EXPRESSION
  申请人：ISIS PHARMACEUTICALS, INC.

  公开号：US20150126719A1

  公开（公告）日：2015-05-07

  Provided herein are oligomeric compounds with conjugate groups targeting apoplipoprotein C-III (ApoCIII). In certain embodiments, the ApoCIII targeting oligomeric compounds are conjugated to N-Acetylgalactosamine. Also disclosed herein are conjugated oligomeric compounds targeting ApoCIII for use in decreasing ApoCIII to treat, prevent, or ameliorate diseases, disorders or conditions related to ApoCIII. Certain diseases, disorders or conditions related to ApoCIII include inflammatory, cardiovascular and/or metabolic diseases, disorders or conditions. The conjugated oligomeric compounds disclosed herein can be used to treat such diseases, disorders or conditions in an individual in need thereof.
• CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE
  申请人：ISIS PHARMACEUTICALS, INC.

  公开号：US20150126718A1

  公开（公告）日：2015-05-07

  Provided herein are oligomeric compounds with conjugate groups. In certain embodiments, the oligomeric compounds are conjugated to N-Acetylgalactosamine.