1-[4-(苄氧基)苯基]-2-(4-羟基-4-苯基-1-哌啶基)-1-丙酮 | 188591-61-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-[4-(苄氧基)苯基]-2-(4-羟基-4-苯基-1-哌啶基)-1-丙酮
• 英文名称: 1-(4-benzyl-oxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanone
• 英文别名: 1-(4-benzoxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanone；1-(4-Benzyloxyphenyl)-2-(4-hydroxy-4-phenyl-1-piperidyl)propan-1-one；2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-(4-phenylmethoxyphenyl)propan-1-one
• CAS: 188591-61-9
• 化学式: C₂₇H₂₉NO₃
• 分子量: 415.532
• InChiKey: LRXIEGZMKNGPLB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-[4-(苄氧基)苯基]-2-(4-羟基-4-苯基-1-哌啶基)-1-丙酮 生成 (1R,2S)-1-(4-benzoxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol
  参考文献：
  名称：

  Process for the preparation of nonracemic syn-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenyl -piperidin-1-yl)-1-propanol compounds

  摘要：

  本发明提供了一种制备非外消旋对映体1-(4-苯氧基苯基)-2-(4-羟基-4-苯基哌啶-1-基)-1-丙醇的方法，通过使用催化剂体系对相应的非外消旋1-(4-苯氧基苯基)-2-(4-羟基-4-苯基哌啶-1-基)-1-丙酮进行加氢反应，所述催化剂体系包括钌、非外消旋二膦配体、从氨基硫醚和非手性二胺中选择的双齿胺配体以及碱。

  公开号：

  US20030144521A1

文献信息

• Process for the preparation of the mesylate salt trihydrate of 1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol and intermediates useful therefor
  申请人：——

  公开号：US20020016466A1

  公开（公告）日：2002-02-07

  The present invention is directed to a novel process for the preparation of the mesylate trihydrate of the compound of formula (I), (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol: 1 The present invention is further directed to a process for the preparation of a (2S)-(+)-compound of formula (II): 2 wherein R 1 is a protecting group. In addition, the present invention relates to intermediates useful in said processes.

  本发明涉及一种制备公式(I)化合物的甲磺酸三水合物的新工艺，其中，(1S,2S)-1-(4-羟基苯基)-2-(4-羟基-4-苯基哌啶-1-基)-1-丙醇；本发明还涉及一种制备公式(II)的(2S)-(+)-化合物的工艺，其中R1是保护基。此外，本发明还涉及在所述工艺中有用的中间体。
• Process for the preparation of nonracemic syn-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol compounds
  申请人：DSM Catalytica Pharmaceuticals, Inc.

  公开号：US06743921B2

  公开（公告）日：2004-06-01

  The present invention provides a process for the preparation of a nonracemic diastereomer of 1-(4-benzoxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanol by hydrogenation of a corresponding nonracemic 1-(4-benzoxy-phenyl)-2-(4-hydroxy-4-phenyl-piperidin-1-yl)-1-propanone using a catalyst system comprising ruthenium, a nonracemic diphosphine ligand, a bidentate amine ligand selected from amino-thioethers and achiral diamines, and a base.

  本发明提供了一种制备非外消旋对映体1-(4-苯氧基苯基)-2-(4-羟基-4-苯基哌啶-1-基)-1-丙醇的方法，其通过对应的非外消旋1-(4-苯氧基苯基)-2-(4-羟基-4-苯基哌啶-1-基)-1-丙酮进行氢化反应，使用包含钌、非外消旋双膦配体、选择自氨基硫醚和无手性二胺的双齿胺配体以及碱的催化剂体系。
• PROCESS FOR THE PREPARATION OF NONRACEMIC SYN-1-(4-HYDROXY-PHENYL)-2-(4-HYDROXY-4-PHENYL.PIPERIDIN-1Yl)-1-PROPANOL COMPOUNDS
  申请人：DSM Pharmaceuticals, Inc.

  公开号：EP1497245A1

  公开（公告）日：2005-01-19
• Process for preparing nonracemic chiral alcohols
  申请人：DSM N.V.

  公开号：US20030181318A1

  公开（公告）日：2003-09-25

  The present invention provides a catalyst system and a process for the preparation of a nonracemic chiral alcohol by hydrogenation of a ketone using the catalyst system, wherein the catalyst system comprises ruthenium, a nonracemic nonatropisomeric chiral diphosphine ligand, an achiral diamine ligand, and a base.
• US6570018B2
  申请人：——

  公开号：US6570018B2

  公开（公告）日：2003-05-27