氘代烟酰胺 | 347841-88-7

• 物质功能分类: 化学试剂 - 氘代试剂
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 氘代烟酰胺
• 中文别名: 烟酰胺-2,4,5,6-d4
• 英文名称: Nicotinamide-d4
• 英文别名: 2,4,5,6-tetradeuteriopyridine-3-carboxamide
• CAS: 347841-88-7
• 化学式: C6H6N2O
• 分子量: 126.15
• InChiKey: DFPAKSUCGFBDDF-RHQRLBAQSA-N

物化性质

• 熔点：
  125-127°C
• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  56
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36/37/39,S45
• 危险类别码：
  R36/37/38

反应信息

• 作为产物：
  描述：

  3-氰基吡啶 、 重水 以250%的产率得到
  参考文献：
  名称：

  WERSTIUK, NICK HENRY;JU, CHEN, CAN. J. CHEM., 67,(1989) N, C. 5-10

  摘要：

  DOI：

文献信息

• NOVEL PYRIDYLOXYACETYL TETRAHYDROISOQUINOLINE COMPOUNDS USEFUL AS NAMPT INHIBITORS
  申请人：ELI LILLY AND COMPANY

  公开号：US20160229835A1

  公开（公告）日：2016-08-11

  The present invention provides novel pyridyloxyacetyl tetrahydroisoquinoline compounds that inhibit NAMPT and may be useful in the treatment of cancer.

  本发明提供了新型的吡啶氧乙酰基四氢异喹啉化合物，可抑制NAMPT，并可能用于癌症治疗。
• METHODS FOR ANALYSIS OF VITAMINS
  申请人：Huang Min

  公开号：US20090203145A1

  公开（公告）日：2009-08-13

  The invention relates to methods for determining the level of B vitamins in a test sample. The methods can include the steps of obtaining a water soluble vitamin fraction by extraction in acidic aqueous solution of a test sample, wherein the vitamin fraction comprises one or more B vitamins having at least a predetermined minimum concentration; adding a vitamin standard comprising one or more B vitamins of known quantity to a portion of the vitamin fraction of the test sample, wherein said vitamins in the vitamin standard comprise an isotope label and wherein the vitamin standard is added in an amount sufficient to determine the level of the corresponding vitamins in the test sample; and determining the level of one or more vitamins in the test sample corresponding to one or more of the vitamins in the vitamin standard using mass spectrometry.
• [EN] METHODS FOR ANALYSIS OF VITAMINS<br/>[FR] PROCÉDÉS D'ANALYSE DE VITAMINES
  申请人：COVANCE LAB INC

  公开号：WO2009100229A1

  公开（公告）日：2009-08-13

  The invention relates to methods for determining the level of B vitamins in a test sample. The methods can include the steps of obtaining a water soluble vitamin fraction by extraction in acidic aqueous solution of a test sample, wherein the vitamin fraction comprises one or more B vitamins having at least a predetermined minimum concentration; adding a vitamin standard comprising one or more B vitamins of known quantity to a portion of the vitamin fraction of the test sample, wherein said vitamins in the vitamin standard comprise an isotope label and wherein the vitamin standard is added in an amount sufficient to determine the level of the corresponding vitamins in the test sample; and determining the level of one or more vitamins in the test sample corresponding to one or more of the vitamins in the vitamin standard using mass spectrometry.