1-乙氧基丁烷-2-酮 | 76086-05-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-乙氧基丁烷-2-酮
• 英文名称: 1-Ethoxy-2-butanon
• 英文别名: 1-Ethoxy-butan-2-on；1-ethoxy-2-oxobutane；ethoxy-2-butanone；1-ethoxy-butan-2-one；α-Aethoxy-β-oxo-butan；Aethoxymethyl-aethyl-keton；1-Aethoxy-butan-2-on；Ethyl ethoxymethyl ketone；1-ethoxybutan-2-one
• CAS: 76086-05-0
• 化学式: C₆H₁₂O₂
• 分子量: 116.16
• InChiKey: FRFMOVPIHHDDPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-乙氧基丁烷-2-酮 在 氢氧化钾 、 乙醚 、 硫酸 作用下， 生成 ethyl-(2-ethylidene-hex-5-en-3-ynyl)-ether
  参考文献：
  名称：

  Wartanjan; Shamagorzjan, Izvestiya Akademii Nauk Armyanskoi SSR, Khimicheskie Nauki, 1958, vol. 11, p. 99,104

  摘要：

  DOI：
• 作为产物：
  描述：

  1-ethoxy-2-butanol 在 chromium(VI) oxide 作用下， 生成 1-乙氧基丁烷-2-酮
  参考文献：
  名称：

  Some Nucleophilic Displacements on 3-Bromo-1,2-epoxybutane and 1-Bromo-2,3-epoxybutane

  摘要：

  DOI：

  10.1021/ja01632a021

文献信息

• [EN] CONJUGATES COMPRISING CELL-BINDING AGENTS AND CYTOTOXIC AGENTS<br/>[FR] CONJUGUÉS COMPRENANT DES AGENTS DE LIAISON CELLULAIRE ET DES AGENTS CYTOTOXIQUES
  申请人：IMMUNOGEN INC

  公开号：WO2016036794A1

  公开（公告）日：2016-03-10

  The invention relates to novel cell-binding agent-cytotoxic agent conjugates, wherein the cell-binding agent (CBA) is covalently linked to the cytotoxic agent through an aldehyde group obtained from oxidation of a 2-hydroxyethylamine moiety on the CBA. The invention also provides methods of preparing the conjugates of the present invention. The invention further provides composition and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the conjugates of the invention.

  该发明涉及一种新型细胞结合剂-细胞毒剂偶联物，其中细胞结合剂（CBA）通过氧化CBA上的2-羟乙胺基团得到的醛基与细胞毒剂共价连接。该发明还提供了制备本发明偶联物的方法。该发明还提供了使用该发明的偶联物抑制异常细胞生长或治疗哺乳动物增生性疾病的组合物和方法。
• DIHYDROXYACETONE MONOETHERS
  申请人：Buehle Philipp

  公开号：US20130272978A1

  公开（公告）日：2013-10-17

  The present invention relates to the use of dihydroxyacetone monoethers as self-tanning substance, to preparations comprising dihydroxyacetone monoethers, and to certain dihydroxyacetone monoethers and to a process for the preparation thereof.

  本发明涉及将二羟基丙酮单醚用作自然晒黑物质，涉及含有二羟基丙酮单醚的制剂，涉及某些二羟基丙酮单醚以及其制备方法。
• Water soluble chiral diphoshpines
  申请人：——

  公开号：US20040102649A1

  公开（公告）日：2004-05-27

  The invention concerns a water soluble compound of formula (a) wherein: A represents naphthyl or phenyl; and Ar 1 and Ar 2 independently represent a saturated or aromatic carbocyclic group; X a , X b are independently selected among an amino group, an ammonium group and an amino group modified by a linear polyoxyalkylene chain, provided that at least one of X a and X b represents ammonium or modified amino.

  本发明涉及一种水溶性化合物，其化学式为（a），其中：A代表萘基或苯基；Ar1和Ar2分别代表饱和或芳香环烃基；Xa，Xb分别独立地选自氨基，铵基和通过线性聚氧烷链修饰的氨基，但至少其中之一代表铵基或修饰氨基。
• BICYCLIC HETEROCYCLIC DERIVATIVE
  申请人：Nakahira Hiroyuki

  公开号：US20110190278A1

  公开（公告）日：2011-08-04

  The present invention relates to a compound of the following formula (I) or a pharmaceutically acceptable salt thereof, being useful as a renin inhibitor. [wherein R 1a is halogen, etc.; R 1m is H, etc.; G 1 is —N(R 1b )—, etc.; G 2 is —CO—, etc.; G 3 is —C(R 1c )(R 1d )—, etc.; G 4 is oxygen, etc.; R 1b is optionally substituted C 1-6 alkyl, etc.; R 1c and R 1d are independently the same or different, H, etc.; R 3 is H, optionally substituted C 1-6 alkyl, etc.; R 3a , R 3b , R 3 c and R 3d are independently the same or different, and a group: -A-B (said A is single bond, etc., and said B is H, etc.), etc.; and n is 1, etc.]

  本发明涉及以下式（I）的化合物或其药学上可接受的盐，其可用作肾素抑制剂。[其中，R1a是卤素等；R1m是H等；G1是—N（R1b）—等；G2是—CO—等；G3是—C（R1c）（R1d）—等；G4是氧等；R1b是可选取代的C1-6烷基等；R1c和R1d独立选择为H等；R3是H、可选取代的C1-6烷基等；R3a、R3b、R3c和R3d独立选择为相同或不同的基团：-A-B（其中A是单键等，B是H等）等；n为1等。]
• N-SUBSTITUTED-CYCLIC AMINO DERIVATIVE
  申请人：Suetsugu Satoshi

  公开号：US20120122773A1

  公开（公告）日：2012-05-17

  The present invention provides a compound of formula (I): wherein R 1a is optionally substituted C 1-6 alkyl, etc.; R 1m is hydrogen atom, etc.; G 1 , G 2 , G 3 and G 4 are (i), etc. ((i) G 1 is —N(R 1b )—, G 2 is —CO—, G 3 is —C(R 1c )(R 1d )—, and G 4 is oxygen, etc.); R 1b is optionally substituted C 1-6 alkyl, etc.; R 1c and R 1d are each independently optionally substituted C 1-6 alkyl, etc.; R 2 is optionally substituted C 1-6 alkyl, etc.; R 3a , R 3b , R 3c and R 3d are each independently a group: -A-B (A is a single bond, etc., B is hydrogen atom, etc.), etc.; n is 1, etc.; R 5 is C 1-4 alkoxycarbonyl, etc., or a pharmaceutically acceptable salt thereof, which is useful as a renin inhibitor.

  本发明提供了一种化合物，其化学式为(I)：其中R1a是可选取代的C1-6烷基等；R1m是氢原子等；G1，G2，G3和G4是(i)等，((i) G1是—N(R1b)—，G2是—CO—，G3是—C(R1c)(R1d)—，G4是氧原子等)；R1b是可选取代的C1-6烷基等；R1c和R1d分别独立地是可选取代的C1-6烷基等；R2是可选取代的C1-6烷基等；R3a、R3b、R3c和R3d分别独立地是一种基团：-A-B（其中A是单键等，B是氢原子等）等；n是1等；R5是C1-4烷氧羰基等，或其药学上可接受的盐，其作为一种肾素抑制剂是有用的。