氟草敏 | 27314-13-2

• 物质功能分类: 化学农药原药
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 氟草敏
• 中文别名: 达草灭；达草呋；达草呋/4-氯-5-(甲胺)-2-(ALPHA,ALPHA,ALPHA-三氟-间-甲苯基)-3(2H)-哒嗪酮；达草灭标准品；哒草伏Norflurazon
• 英文名称: norfluazon
• 英文别名: Norflurazon；4-chloro-5-methylamino-2-(α,α,α-trifluoro-m-tolyl)-pyridazin-3(2H)-one；4-chloro-5-(methylamino)-2-[3-(trifluoromethyl)phenyl]pyridazin-3-one；4-chloro-5-(methylamino)-2-[3-(trifluoromethyl)phenyl]-3(2H)-pyridazinone
• CAS: 27314-13-2
• 化学式: C₁₂H₉ClF₃N₃O
• 分子量: 303.671
• InChiKey: NVGOPFQZYCNLDU-UHFFFAOYSA-N

物化性质

• 熔点：
  184℃
• 沸点：
  345.2±52.0 °C(Predicted)
• 密度：
  1.4395 (estimate)
• 溶解度：
  可溶于氯仿（少许）、甲醇（少许）
• 物理描述：
  Norflurazon appears as colorless odorless crystals. Non corrosive. Used as an herbicide.
• 颜色/状态：
  White to greyish brown, crystalline powder
• 气味：
  Odorless
• 蒸汽压力：
  2.89X10-8 mm Hg at 25 °C
• 稳定性/保质期：

  Stable in aqueous solution @ pH 3-9 (<8% loss within 24 hr). ... Stable upon storage (shelf life (@ 20 °C) greater than or equal to 4 yr). ... Rapidly degraded by sunlight.

• 腐蚀性：
  Non-corrosive
• 解离常数：
  No dissociation in range of pH 1 to 12 (25 °C)
• 保留指数：
  2339;2348;2324.5;2328.3;2343;2326.7;2322.4

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  44.7
• 氢给体数：
  1
• 氢受体数：
  6

ADMET

代谢

Norflurazon 以 2 或 110 mg/kg 的单次口服剂量、2 mg/kg 的单次静脉注射剂量，或者在大鼠饮食中添加 2 ppm 并持续 14 天后给予 2 mg/kg 的单次口服剂量给药。在尿液中，96 小时内排除了 18.5-28.4% 的给药剂量，65.3-79.5% 的给药剂量通过粪便排出。分离出了 Norflurazon 的十三个代谢物。Norflurazon 的代谢似乎有四种途径：N-去甲基化；通过谷胱甘肽取代氯原子；谷胱甘肽攻击芳香环；以及氯原子被氢取代...进行了一项额外的代谢研究，以确定在大鼠单次低剂量 1 mg/kg 或单次高剂量 100 mg/kg 口服后，排泄物中是否存在磺酰代谢物。在给予药物的鼠的尿液和粪便中都检测到了磺酰代谢物。在尿液中，低剂量时磺酰代谢物占尿液中放射活性的 0.03%，高剂量时占 0.2%。在粪便中，低剂量时磺酰代谢物占粪便放射活性的 0.3%，高剂量时占 0.1%。

Norflurazon was administered as single oral doses of 2 or 110 mg/kg, a single i.v. dose of 2 mg/kg, or a single oral dose of 2 mg/kg following administration of 2 ppm in animal diet for 14 days to separate groups of rats. In urine, between 18.5-28.4% of the administered dose was eliminated by 96 hours post-dose, and between 65.3-79.5% of the administered dose was eliminated in feces. Thirteen metabolites of norflurazon were isolated. There appear to be 4 pathways for norflurazon metabolism: N-demethylation; displacement of the chlorine atom by glutathione; glutathione attack on the aromatic ring; and replacement of the chlorine atom by hydrogen ... . An additional metabolism study was conducted to determine the presence of the sulfone metabolite in rat excreta after a single low oral dose of 1 mg/kg, or a single high oral dose of 100 mg/kg. The sulfone metabolite was detected in both urine and feces of dosed rats. In urine, the sulfone metabolite accounted for 0.03% of urinary radioactivity at the low dose, and 0.2% of urinary radioactivity at the high dose. The sulfone metabolite accounted for 0.3% of fecal radioactivity at the low dose, and for 0.1% of fecal radioactivity at the high dose.

来源:Hazardous Substances Data Bank (HSDB)

代谢

4-氯-5-二甲氨基-2-(α,α,α-三氟-间-甲苯基)-3(2H)-哒嗪酮在棉花中并没有显著降解。在玉米和大豆中，24小时后在显著的量中观察到了单脱甲基和双脱甲基衍生物。norflurazone的代谢在玉米和大豆中也比棉花要快。

4-Chloro-5-dimethylamino-2-(a,a,a-trifluoro-m- tolyl)-3(2H)-pyridazinone was not degraded to any great extent in cotton. In corn and soybean, significant amounts of the mono- and des-methyl derivatives were seen after 24 hr. Metabolism of norflurazone also was more rapidly in corn and soybean than in cotton.

来源:Hazardous Substances Data Bank (HSDB)

代谢

(14)C 4-氯-5-二甲基氨基-2-(α,α,α-三氟邻甲苯基)-3(2H)-哒嗪酮被加入到带有蔓越莓插条的艾尔伦迈尔烧瓶中的溶液里。随后，分析了叶子、茎和根。在一天之内，根中检测到了去甲氟草酮和一种未识别的代谢物。十五天后，除了去甲氟草酮之外，在叶子、茎和根中还鉴定出了4-氯-5-氨基-2-(α,α,α-三氟邻甲苯基)-3(2H)-哒嗪酮。当将去甲氟草酮应用于植物时，8天后在叶子、茎和根中观察到了4-氯-5-氨基-2-(α,α,α-三氟邻甲苯基)-3(2H)-哒嗪酮和一种未识别的代谢物。

(14)C 4-Chloro-5-dimethylamino-2(a,a,a-trifluroo-m-tolyl)-3(2H)-pyridazinone was added to solutions in Ehrlenmeyer flasks in which cranberry cuttings were propagated. Subsequently, leaf, shoot and root were analyzed. Within one day, norflurazon and an unidentified metabolite were detected in the roots. After 15 days, in addition to norflurazon, 4-chloro-5-amino-2-(a,a,a,-trifluoro-m- tolyl)-3(2H)-pyridazinone was identified in leaf shoot and root. When norflurazon was applied to the plants, 4-chloro-5-amino-2-(a,a,a,-trifluoro-m- tolyl)-3(2H)-pyridazinone and an unidentified metabolite were observed in leaf, stem and root after 8 days.

来源:Hazardous Substances Data Bank (HSDB)

代谢

研究了诺氟沙松在Sprague-Dawley雌性大鼠体内的代谢情况，这些大鼠通过灌胃接受了0、2或110毫克/千克碳-14（C-14）标记的诺氟沙松单次剂量。在给予2毫克/千克放射性标记诺氟沙松的一些大鼠中，之前已经以2毫克/千克未标记诺氟沙松的饮食维持了14天。其他大鼠通过静脉注射（iv）接受了0或2毫克/千克C-14标记的诺氟沙松。收集了4天的尿液、粪便和呼出空气，并分析了诺氟沙松代谢物。在尿液中检测到6种代谢物。除了接受110毫克/千克剂量的大鼠外，诺氟沙松亚砜（NFS）被识别为最丰富的代谢物，占剂量的24%至39%。110毫克/千克大鼠排泄的最丰富代谢物未被识别。在粪便中检测到10种代谢物，其中NFS再次被识别为主要的代谢物。每个剂量中不到2%以未改变的诺氟沙松形式被排泄。作者得出结论，当诺氟沙松口服给予大鼠时，主要通过N-脱甲基和与谷胱甘肽结合的方式被广泛代谢。

The metabolism of norflurazon was investigated in ... female Sprague-Dawley-rats administered single doses of 0, 2, or 110mg/kg carbon-14 (C-14) labeled norflurazon by gavage. Some of the rats given 2mg/kg radiolabeled norflurazon had been maintained on a diet containing 2 mg/kg unlabeled norflurazon for 14 days previously. Other rats were administered 0 or 2 mg/kg C-14 labeled norflurazon intravenously (iv).Urine, feces, and expired air were collected for 4 days and analyzed ... for norflurazon metabolites. ... Six urinary metabolites were detected. Except for rats given the 110mg/kg dose, norflurazon-sulfoxide (NFS) was identified as the most abundant metabolite, accounting for 24 to 39% of the doses. The most abundant metabolite excreted by 110mg/kg rats was not identified. Ten fecal metabolites were detected, with NFS again identified as the predominant metabolite. Less than 2% of each dose was excreted as unchanged norflurazon. The authors conclude that norflurazon when given orally to rats is metabolized extensively primarily by N-demethylation and conjugation with glutathione.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

癌症分类：C组可能的人类致癌物

Cancer Classification: Group C Possible Human Carcinogen

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌物分类

对人类不具有致癌性（未被国际癌症研究机构IARC列名）。

No indication of carcinogenicity to humans (not listed by IARC).

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 人类毒性摘录

本报告涉及一名53岁的专业除草喷雾器操作员，他被推荐进行斑贴测试。他曾出现过一次类似晒伤的急性发作，导致他的眼睛几乎完全闭合，几天后出现类似荨麻疹的皮疹。在那段时间里，他一直在使用Predict配方的去草净。使用1.0%和0.1%的Predict进行斑贴测试，在给药后2天和4天产生了++反应。在20名对照受试者中的测试结果为阴性。去草净在制剂中的浓度为78.6%，但关于惰性成分的信息无法获得。

/CASE REPORTS/ This report concerned a 53 year old professional weed sprayer who was referred for patch testing. He had an acute episode that resembled sunburn and caused his eyes to almost completely close, followed several days later by urticaria like lesions. He had been using the Predict formulation of norflurazon around that time. Patch testing with Predict at 1.0% and 0.1% produced a ++ reaction at 2 and 4 days after dosing. Tests in 20 control subjects were negative. The concentration of norflurazon in the preparation was 78.6%, but information on inert ingredients was not available.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

实验室动物：急性暴露/在利用实验室动物进行的研究中，通常显示氟菌晴的急性毒性较低。通过口服和皮肤途径，以及家兔的眼睛和皮肤刺激性方面，实际上是无毒的。基于这些效果，它被归类为毒性IV类（四个类别中最低的一类）。[美国环保局/OPPTS；氟菌晴的R.E.D.事实。EPA-738-F-96-012，14页（1996年7月）。从2007年2月28日起可从以下网址获得：http://www.epa.gov/REDs/facTSheet/0229fact.pdf]

/LABORATORY ANIMALS: Acute Exposure/ In studies using laboratory animals, norflurazon generally has been shown to be of low acute toxicity. It is practically nontoxic by the oral and dermal routes, as well as in terms of eye and dermal irritation in rabbits. It has been placed in Toxicity Category IV (the lowest of four categories) for these effects.[EPA/OPPTS; R.E.D. Facts for Norflurazone. EPA-738-F-96-012, 14 p. (July 1996). Available from, as of February 28, 2007: http://www.epa.gov/REDs/factsheet/0229fact.pdf]

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

实验室动物：亚慢性或前慢性暴露/进行了一项为期21天的皮肤毒性研究，研究对象为含量80%的可湿性粉剂（WP）的诺氟沙。在这项研究中，3只雄性和3只雌性的新西兰白兔接受了重复的皮肤涂抹诺氟沙80% WP，剂量为150 mg 80% WP/mL（大约375 mg/kg/天）和400 mg 80% WP/mL（大约1000 mg/kg/天），每周5天，每天6-8小时，持续21天。基于两性中碱性磷酸酶活性、肝脏重量和肝脏与体重比的增加，全身NOEL为雄性和雌性均为375 mg/kg/天，全身LEL为雄性和雌性均为1000 mg/kg/天。基于敷料移除后立即观察到的轻微红斑，皮肤NOEL为两性均为375 mg/kg/天，皮肤LEL为两性均为1000 mg/kg/天。[美国环保局/农药项目办公室；诺氟沙重新登记合格决定文件。第5页（1996年）于2007年2月28日之前可从http://www.epa.gov/pesticides/reregistration/status.htm获取]

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ A twenty-one day dermal toxicity study was conducted with norflurazon 80% wettable powder (WP). In this study, male and female New Zealand white rabbits (3 males and 3 females) received repeated dermal application of norflurazon 80% WP at doses of 150 mg 80% WP/mL (approximately 375 mg/kg/day) and 400 mg 80% WP/mL (approximately 1000 mg/kg/day), 5 days per week, 6-8 hours per day, for 21 days. The systemic NOEL is 375 mg/kg/day for males and females, and the systemic LEL is 1000 mg/kg/day for males and females, based on increases in alkaline phosphatase activity, liver weight, and liver to body weight ratio in both sexes. The dermal NOEL is 375 mg/kg/day for both sexes, and the dermal LEL is 1000 mg/kg/day for both sexes, based on slight erythema observed immediately after bandage removal.[USEPA/Office of Pesticide Programs; Reregistration Eligibility Decision Document - Norflurazon. p 5 (1996) Available from, as of February 28, 2007: http://www.epa.gov/pesticides/reregistration/status.htm]

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

两种化合物/SAN-6706和norflurazon/很容易被棉花（Gossypium hirsutum 长角豆科 "Coker 203"）、玉米（Zea mays 长角豆科 "WF9"）和大豆（Glycine max (长角豆科) Merr. "Lee"）植株从营养液中吸收。在玉米和大豆植株中，这些化合物的传输速度比棉花快，并且数量更多。

Both compounds /SAN-6706 and norflurazon/ were readily absorbed from nutrient solution by cotton (Gossypium hirsutum Leguminatae "Coker 203"), corn (Zea mays Leguminatae "WF9") and soybean (Glycine max (Leguminatae) Merr. "Lee") plants. In corn and soybean plants, these compounds were translocated more rapidly and in greater amount than in cotton.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

雌性 Sprague-Dawley 大鼠通过灌胃给予单剂量的 0、2 或 110 mg/kg 碳-14（C-14）标记的氟乐灵。部分给予 2 mg/kg 放射性标记氟乐灵的大鼠在此之前已经连续 14 天饮食中含 2 mg/kg 未标记氟乐灵。其他大鼠通过静脉注射（iv）给予 0 或 2 mg/kg C-14 标记的氟乐灵。收集 4 天内的尿液、粪便和呼出气体，并分析 C-14 活性。... 4 天后处死大鼠以确定 C-14 活性的组织分布。C-14 标记的累积尿排泄量占剂量的 18.5% 至 28.4%。静脉注射的大鼠排泄最多，单次给予 110 mg/kg 剂量的大鼠排泄最少。C-14 活性的累积粪便排泄量占 65.3% 至 79.5%。给予 110 mg/kg 剂量的大鼠排泄的放射性标记最多，而经过 14 天饮食处理后给予 2 mg/kg 的大鼠排泄的最少。只有 0.1% 的剂量通过呼出气体排出。每个剂量中只有不到 1% 在组织和尸体中回收。只有肝脏和肾脏含有相对较高的 C-14 活性水平...

Female Sprague-Dawley-rats were administered single doses of 0, 2, or 110 mg/kg carbon-14 (C-14)-labeled norflurazon by gavage. Some of the rats given 2 mg/kg radiolabeled norflurazon had been maintained on a diet containing 2 mg/kg unlabeled norflurazon for 14 days previously. Other rats were administered 0 or 2 mg/kg C-14 labeled norflurazon intravenously (iv). Urine, feces, and expired air were collected for 4 days and analyzed for C-14 activity. ... The rats were killed after 4 days to determine the tissue distribution of C-14 activity. Cumulative urinary excretion of C-14 label ranged from 18.5 to 28.4% of the doses. The largest excretion was by rats dosed iv and the smallest by rats given the single 110 mg/kg dose. Cumulative fecal excretion of C-14 activity ranged from 65.3 to 79.5%. Rats given the 110 mg/kg dose excreted the most radiolabel and those given 2 mg/kg after 14 days of dietary treatment the least. Only 0.1% of the doses was eliminated in the expired air. Less than 1% of each dose was recovered in the tissues and carcass. Only the liver and kidney contained relatively high levels of C-14 activity...

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

(14)C 4-氯-5-二甲基氨基-2-(α,α,α-三氟邻甲苯基)-3(2H)-哒嗪酮被加入到带有蔓越莓插条的艾尔伦迈尔烧瓶中的溶液里。随后，分析了叶子、茎和根。在一天之内，根中检测到了去甲氟草酮和一种未识别的代谢物。十五天后，除了去甲氟草酮之外，在叶子、茎和根中还鉴定出了4-氯-5-氨基-2-(α,α,α-三氟邻甲苯基)-3(2H)-哒嗪酮。当将去甲氟草酮施用到植物上后，8天后在叶子、茎和根中观察到了4-氯-5-氨基-2-(α,α,α-三氟邻甲苯基)-3(2H)-哒嗪酮和一种未识别的代谢物。

(14)C 4-Chloro-5-dimethylamino-2(a,a,a-trifluroo-m-tolyl)-3(2H)-pyridazinone was added to solutions in Ehrlenmeyer flasks in which cranberry cuttings were propagated. Subsequently, leaf, shoot and root were analyzed. Within one day, norflurazon and an unidentified metabolite were detected in the roots. After 15 days, in addition to norflurazon, 4-chloro-5-amino-2-(a,a,a,-trifluoro-m- tolyl)-3(2H)-pyridazinone was identified in leaf shoot and root. When norflurazon was applied to the plants, 4-chloro-5-amino-2-(a,a,a,-trifluoro-m- tolyl)-3(2H)-pyridazinone and an unidentified metabolite were observed in leaf, stem and root after 8 days.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险品标志：
  N
• 危险类别码：
  R50
• 危险品运输编号：
  UN 3077 9/PG 3
• 安全说明：
  S61
• WGK Germany：
  3

制备方法与用途

介绍
将50毫升含20克/升海盐和1克/升酵母提取物的培养基，在120℃下高压灭菌20分钟。随后，以9克/升浓度添加D(+)-葡萄糖至该培养基中。将这种50毫升培养基置于250毫升锥形瓶(Erlenmeyer flask) 中，并加入二甲基亚砜溶解的氟草敏(达草呋)(Supleco)，其终浓度为0.2克/升。接着，添加1毫升在相同培养基（25克/升海盐、10克/升酵母提取物和9克/升葡萄糖）中培养24小时的ONC-T18预培养物(接种物)。在室温下以130转/分钟的振荡速率培养四天。培养结束后，通过以4300转/分钟离心10分钟收集细胞，用蒸馏水洗涤一次，并再次以相同转速和时间离心。将所得的细胞沉淀物冷冻干燥、称重并从中提取油。

类别 农药

毒性分级 低毒

急性毒性 口服 - 大鼠 LD50: 8000 毫克/公斤

可燃性危险特性 燃烧产生有毒氯化物、氟化物和氮氧化物气体

储运特性 库房通风低温干燥；与食品原料分开储运

灭火剂 干粉、泡沫、砂土

反应信息

• 作为反应物：
  描述：

  戊炔草胺 、 maleic acid monohydrazide 、 3-氨基-1,2,4-三氮唑 、 monosodium methanearsonate 、 Disodium methylarsonate 、 双苯酰草胺 、 、 地乐灵 、 磺乐灵 、 、 4-氨基-3,5,6-三氯吡啶羧酸 、 2,3-二氯-1,4-萘醌 、 敌灭生 、 、 、 百草枯 、 、 、 异恶草酮 、 N-(1-ethylpropyl)-3,4-dimethyl-2,6-dinitrobenzamide 、 氟草敏 、 生成 2-氯-N,N-二烯丙基乙酰胺
  参考文献：
  名称：

  6-arylpyrimidines and herbicidal use

  摘要：

  一类6-芳基嘧啶类化合物可用于除草，其一般式为：##STR1##其中R.sup.2选自氢、卤素、取代或未取代的烷基、卤代烷基、多卤代烷基、卤代烯基、多卤代烯基、卤代炔基、多卤代炔基、烯基、炔基、烷氧基、烷硫基、烷氧羰基烷基、氰基、烷氧基烷基、烷氧羰基、环烷基、芳基烷基、烷基氨基、二烷基氨基或二烷基氨基羰基；R.sup.3为烷基、烯基、炔基或卤代烷基；R.sup.5为烷基、烯基、炔基、烯炔基或烷氧基烷基；R.sup.6为芳基（例如芳香环）；X为氧或硫。R.sup.2和R.sup.3可以形成融合环。

  公开号：

  US05397767A1
• 作为产物：
  描述：

  甲胺 、 4,5-二氯-2-(3-三氟甲基苯基)-3(2H)哒嗪酮 以 甲苯 为溶剂， 反应 7.0h， 以27%的产率得到5-Chloro-4-methylamino-2-(3-trifluoromethyl-phenyl)-2H-pyridazin-3-one
  参考文献：
  名称：

  Konecny, Vaclav; Kovac, Stefan; Varkonda, Stefan, Collection of Czechoslovak Chemical Communications, 1985, vol. 50, # 2, p. 492 - 502

  摘要：

  DOI：

文献信息

• [EN] ACC INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE L'ACC ET UTILISATIONS ASSOCIÉES
  申请人：GILEAD APOLLO LLC

  公开号：WO2017075056A1

  公开（公告）日：2017-05-04

  The present invention provides compounds I and II useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

  本发明提供了化合物I和II，这些化合物可用作乙酰辅酶A羧化酶（ACC）的抑制剂，以及它们的组合物和使用方法。
• [EN] 3-[(HYDRAZONO)METHYL]-N-(TETRAZOL-5-YL)-BENZAMIDE AND 3-[(HYDRAZONO)METHYL]-N-(1,3,4-OXADIAZOL-2-YL)-BENZAMIDE DERIVATIVES AS HERBICIDES<br/>[FR] DÉRIVÉS DE 3-[(HYDRAZONO))MÉTHYL]-N-(TÉTRAZOL-5-YL)-BENZAMIDE ET DE 3-[(HYDRAZONO)MÉTHYL]-N-(1,3,4-OXADIAZOL-2-YL)-BENZAMIDE UTILISÉS EN TANT QU'HERBICIDES
  申请人：SYNGENTA CROP PROTECTION AG

  公开号：WO2021013969A1

  公开（公告）日：2021-01-28

  The present invention related to compounds of Formula (I): or an agronomically acceptable salt thereof, wherein Q, R2, R3, R4, R5 and R6 are as described herein. The invention further relates to compositions comprising said compounds, to methods of controlling weeds using said compositions, and to the use of compounds of Formula (I) as a herbicide.

  本发明涉及以下式（I）的化合物或其农业上可接受的盐，其中Q、R2、R3、R4、R5和R6如本文所述。该发明还涉及包含所述化合物的组合物，使用这些组合物控制杂草的方法，以及将式（I）的化合物用作除草剂的用途。
• [EN] INSECTICIDAL TRIAZINONE DERIVATIVES<br/>[FR] DÉRIVÉS DE TRIAZINONE INSECTICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2013079350A1

  公开（公告）日：2013-06-06

  Compounds of the formula (I) or (I'), wherein the substituents are as defined in claim 1, are useful as pesticides.

  式(I)或(I')的化合物，其中取代基如权利要求1所定义的那样，可用作杀虫剂。
• [EN] HERBICIDALLY ACTIVE HETEROARYL-S?BSTIT?TED CYCLIC DIONES OR DERIVATIVES THEREOF<br/>[FR] DIONES CYCLIQUES SUBSTITUÉES PAR HÉTÉROARYLE À ACTIVITÉ HERBICIDE OU DÉRIVÉS DE CELLES-CI
  申请人：SYNGENTA LTD

  公开号：WO2011012862A1

  公开（公告）日：2011-02-03

  The invention relates to a compound of formula (I), which is suitable for use as a herbicide wherein G is hydrogen or an agriculturally acceptable metal, sulfonium, ammonium or latentiating group; Q is a unsubstituted or substituted C3-C8 saturated or mono-unsaturated heterocyclyl containing at least one heteroatom selected from O, N and S, or Q is heteroaryl or substituted heteroaryl; m is 1, 2 or 3; and Het is an optionally substituted monocyclic or bicyclic heteroaromatic ring; and wherein the compound is optionally an agronomically acceptable salt thereof.

  该发明涉及一种化合物，其化学式为(I)，适用作为除草剂，其中G为氢或农业可接受的金属、磺酸盐、铵盐或潜伏基团；Q为未取代或取代的含有至少一个来自O、N和S的杂原子的饱和或单不饱和的C3-C8杂环烷基，或Q为杂芳基或取代的杂芳基；m为1、2或3；Het为可选择地取代的单环或双环杂芳环；且该化合物可选择地为其农学上可接受的盐。
• TRIAZOLE ACC INHIBITORS AND USES THEREOF
  申请人：Gilead Apollo, LLC

  公开号：US20170166584A1

  公开（公告）日：2017-06-15

  The present invention provides triazole compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

  本发明提供了三唑化合物，可用作乙酰辅酶A羧化酶（ACC）的抑制剂，以及其组合物和使用方法。

表征谱图