Disodium methylarsonate | 144-21-8

• 物质功能分类: 化学农药原药 - 除草剂 - 其他除草剂
• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: Disodium methylarsonate
• 英文别名: disodium;methyl-dioxido-oxo-λ5-arsane
• CAS: 144-21-8；2163-80-6
• 化学式: CH3AsNa2O3
• 分子量: 183.934
• InChiKey: SDIXRDNYIMOKSG-UHFFFAOYSA-L

物化性质

• 熔点：
  >355 °C
• 沸点：
  165°C
• 密度：
  1.1500
• 溶解度：
  轻微溶于水
• 颜色/状态：
  Hydrated crystals containing 5H2O or 6H2O
• 味道：
  Pleasant acid taste
• 蒸汽压力：
  10-7 mm Hg @ 25 °C
• 稳定性/保质期：

  DECOMPOSED BY STRONG OXIDIZING & REDUCING AGENTS.

• 分解：
  When heated to decomposition it emits toxic fumes of /arsenic & sodium oxide/.
• 腐蚀性：
  NON-CORROSIVE TO IRON, RUBBER AND MOST PLASTICS
• 解离常数：
  pKa1 = 4.1; pKa2 = 8.94

计算性质

• 辛醇/水分配系数(LogP)：
  -8.29
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  63.2
• 氢给体数：
  0
• 氢受体数：
  3

ADMET

代谢

... 检查了DSMA的 ... 在紫色香附子（莎草属植物圆形L）。... 从（14）C DSMA处理的植物中呼吸的二氧化碳中检测到放射性，表明C-AS键降解。

... EXAMINED REACTION PRODUCTS OF DSMA ... IN PURPLE NUTSEDGE (CYPERUS ROTUNDUS L). ... RADIOACTIVITY WAS ... DETECTED IN RESPIRATORY CARBON DIOXIDE FROM (14)C DSMA-TREATED PLANTS, INDICATING C-AS BOND DEGRADATION.

来源:Hazardous Substances Data Bank (HSDB)

代谢

...处理的...百慕大草（狗牙根豆科牧草）用（14）C DSMA。分子保持完整，但...配合物。80%热乙醇提取物含有未知...少量（14）C二氧化碳（0.1%）...在处理10天后在呼吸二氧化碳中找到。

... TREATED ... BERMUDA GRASS (CYNODON DACTYLON LEGUMINOSAE PERS) WITH (14)C DSMA. MOLECULE REMAINED INTACT, BUT ... COMPLEXED. 80% HOT ETHANOL EXTRACT CONTAINED UNKNOWN ... LITTLE (14)C CARBON DIOXIDE (0.1%) ... FOUND IN RESPIRATORY CARBON DIOXIDE 10 DAYS AFTER TREATMENT.

来源:Hazardous Substances Data Bank (HSDB)

代谢

DSMA处理的土壤中气体砷的演化是有机物和水分含量的函数。最大的砷损失来自含有11%添加有机物并在还原条件下保持的土壤。吸附的砷主要以铁砷酸盐的形式存在。铝砷酸盐是次丰富形式。

Evolution of gaseous arsenic from DSMA-treated soil was a function of organic matter and moisture content. Greatest loss of arsenic was from soil containing 11% added organic matter and maintained under reduced conditions. The sorbed arsenic was predominantly in the form of iron arsenate. Aluminum arsenate was the next most abundant form.

来源:Hazardous Substances Data Bank (HSDB)

代谢

研究已经确定，从含有DSMA的短头青霉培养物中演变的化合物是三甲基胂烷。

Studies have identified the compound evolved from cultures of Penicillium brevicaule containing DSMA as trimethylarsine.

来源:Hazardous Substances Data Bank (HSDB)

代谢

志愿者口服单剂500毫克砒霜（亚砷酸钠）。四天后，摄入的砒霜中有78%通过尿液排出。亚砷酸酯中有13%甲基化成二甲胂酸盐。

VOLUNTEERS INGESTED A SINGLE ORAL DOSE OF 500 MG ARSENIC AS DISODIUM METHANEARSONATE. AFTER 4 DAYS, 78% OF INGESTED ARSENIC WAS EXCRETED IN URINE. METHANEARSONATE IS 13% METHYLATED INTO DIMETHYLARSINATE.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

癌症分类：不太可能对人类致癌

Cancer Classification: Not Likely to be Carcinogenic to Humans

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 毒性数据

LC50 (大鼠) > 6,000 毫克/立方米

LC50 (rat) > 6,000 mg/m3

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 人类毒性摘录

包含的化合物为甲酸和其钠盐；34例中有9例出现全身症状，其余有眼部和皮肤刺激。

COMPOUNDS INCLUDED METHANEARSONIC ACID & ITS SODIUM SALTS; 9/34 CASES SHOWED SYSTEMIC SYMPTOMS & REMAINDER HAD EYE & SKIN IRRITATION.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

有机砷化合物包括甲基胂酸钠...和氨基甲基砷酸钠。这些化合物对人类的有毒性远低于...无机砷化合物；然而，如果吸入、吞咽或接触到眼睛或皮肤，它们也是有害的。

ORGANIC ARSENICALS INCLUDE DISODIUM METHYLARSONATE ... AND AMINE METHYLARSONATE. TOXICITY OF THESE CMPD TO HUMANS IS CONSIDERABLY LESS THAN ... INORGANIC ARSENICALS; HOWEVER THEY ARE HARMFUL IF INHALED, SWALLOWED, OR IF THEY COME IN CONTACT WITH EYES OR SKIN.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

经口摄入和吸入均有毒。

Toxic by ingestion and inhalation.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

使用(14)C标记的DSMA，研究表明DSMA能被百慕大草从营养液中迅速吸收，但从土壤中吸收较慢。大约25%的DSMA在5天内被转运到根部和匍匐茎。检测到少量的二氧化碳，C-AS键大部分保持完整。

USING (14)C LABELED DSMA, STUDIES SHOWED THAT DSMA .. READILY TAKEN UP BY BERMUDAGRASS FROM ... NUTRIENT SOLN BUT... SLOWLY FROM SOIL. ... ABOUT 25% ... TRANSLOCATED TO ROOTS & RHIZOMES WITHIN 5 DAYS. SMALL AMT OF CARBON DIOXIDE ... DETECTED. ... C-AS BOND REMAINED LARGELY INTACT ... .

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

初步报告显示... DSMA... 在植物中未发生转运... 然而... 检查了单颗莎草块茎到末端块茎芽的氨甲基砷酸盐的转运。砷被转运了... 到至少隔了四个块茎的块茎上... /氨甲基砷酸盐/

EARLY REPORTS INDICATED ... DSMA ... NOT TRANSLOCATED IN PLANTS ... HOWEVER ... EXAMINED TRANSLOCATION OF AMMONIUM METHYLARSONATE TO SHOOTS OF SINGLE NUTSEDGE TUBERS & TO TERMINAL TUBER SHOOTS. ARSENIC WAS TRANSLOCATED ... LATERALLY TO TUBERS SEPARATED BY AT LEAST FOUR TUBERS FROM TUBER'S SHOOT ... . /AMMONIUM METHYLARSONATE/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

... 对紫叶苜蓿进行了DSMA的转运研究 ... 在叶面施用后。... 研究表明 ... 胞外与共质体运动 ... DSMA在 ... 顶向下与基向下的方向上移动 ... 砷 ... 在重复施用后在末端块茎中积累。

... STUDIED TRANSLOCATION OF DSMA ... IN PURPLE NUTSEDGE FOLLOWING FOLIAR APPLICATION. ... STUDIES INDICATED ... APOPLASTIC & SYMPLASTIC MOVEMENT ... DSMA MOVED IN ... ACROPETAL & BASIPETAL DIRECTIONS ... ARSENIC ... ACCUMULATED IN TERMINAL TUBERS AFTER REPEATED APPLICATIONS.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

... 发现砷从叶片应用到DSMA后转移到了约翰逊草的根状茎和叶再生部分。在海滨百慕大草中发现了向上和向下转移的现象。大约25%的砷被叶片拦截后转移到了根部和根状茎。 ...

... FOUND MOVEMENT OF ARSENIC INTO RHIZOMES AND FOLIAR REGROWTH OF JOHNSONGRASS FOLLOWING FOLIAR APPLICATION OF DSMA. ... FOUND ACROPETAL AND BASIPETAL TRANSLOCATION ... IN COASTAL BERMUDA GRASS. APPROXIMATELY 25% OF ARSENIC INTERCEPTED BY LEAVES ... TRANSLOCATED TO ROOTS AND RHIZOMES ... .

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险等级：
  6.1(b)
• 危险品标志：
  Xn
• 安全说明：
  S26
• 危险类别码：
  R22
• 危险品运输编号：
  2759
• RTECS号：
  PA2275000
• 海关编码：
  2931900090
• 包装等级：
  III
• 危险类别：
  6.1(b)

制备方法与用途

用途：是制造田安的原材料，同时也是杀雄剂。

类别：农药

毒性分级：中毒

急性毒性：

• 大鼠口服 LD50: 821 毫克/公斤
• 小鼠口服 LD50: 1150 毫克/公斤

可燃性危险特性：受热分解产生有毒砷化物气体。

储运特性：

• 库房应通风、低温干燥
• 必须与食品原料分开储存和运输

灭火剂：砂土、干粉、泡沫

职业标准：时间加权平均容许浓度（TWA）0.5 毫克/立方米（砷）。

反应信息

• 作为反应物：
  描述：

  Disodium methylarsonate 、 硫酸 、 亚膦酸 以55%的产率得到
  参考文献：
  名称：

  RHEINGOLD, A. L., ORGANOMET. SYNTH. VOL. 3, AMSTERDAM E. A.,(1986) 618-620

  摘要：

  DOI：

文献信息

• 6-arylpyrimidines and herbicidal use
  申请人：Rohm and Haas Company

  公开号：US05397767A1

  公开（公告）日：1995-03-14

  A class of 6-arylpyrimidines which is useful in the control of weeds is of the general formulae: ##STR1## wherein R.sup.2 is selected from hydrogen, halo, substituted or unsubstituted alkyl, haloalkyl, polyhaloalkyl, haloalkenyl, polyhaloalkenyl, haloalkynyl, polyhaloalkynyl, alkenyl, alkynyl, alkoxy, alkylthio, alkoxycarbonylalkyl, cyano, alkoxyalkyl, alkoxycarbonyl, cycloalkyl, aralkyl, alkylamino, dialkylamino, or dialkylaminocarbonyl group; R.sup.3 is an alkyl, alkenyl, alkynyl, or haloalkyl group; R.sup.5 is an alkyl, alkenyl, alkynyl, alkenynyl, or alkoxyalkyl, group; R.sup.6 is an aryl group (e.g. aromatic ring); and X is oxygen or sulfur. R.sup.2 and R.sup.3 may form a fused ring.

  一类6-芳基嘧啶类化合物可用于除草，其一般式为：##STR1##其中R.sup.2选自氢、卤素、取代或未取代的烷基、卤代烷基、多卤代烷基、卤代烯基、多卤代烯基、卤代炔基、多卤代炔基、烯基、炔基、烷氧基、烷硫基、烷氧羰基烷基、氰基、烷氧基烷基、烷氧羰基、环烷基、芳基烷基、烷基氨基、二烷基氨基或二烷基氨基羰基；R.sup.3为烷基、烯基、炔基或卤代烷基；R.sup.5为烷基、烯基、炔基、烯炔基或烷氧基烷基；R.sup.6为芳基（例如芳香环）；X为氧或硫。R.sup.2和R.sup.3可以形成融合环。
• Halopyridyl triazolinone herbicides and herbicidal use thereof
  申请人：Rohm and Haas Company

  公开号：US05733849A1

  公开（公告）日：1998-03-31

  Disclosed are herbicidal halopyridyl triazolinones, herbicidal compositions comprising the halopyridyl triazolinones, and herbicidal use of the compounds and compositions. Such compounds and compositions are useful as both preemergence and postemergence herbicides in a variety of crops.

  本发明涉及除草的卤代吡啶基三唑啉酮，包含该卤代吡啶基三唑啉酮的除草组合物，以及该化合物和组合物的除草用途。这种化合物和组合物在各种农作物中作为早期和后期除草剂都很有用。