1-氨基-7-溴茚满盐酸盐 | 1071449-08-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 中文名称: 1-氨基-7-溴茚满盐酸盐
• 英文名称: 7-bromo-2,3-dihydro-1H-inden-1-amine
• CAS: 1071449-08-5
• 化学式: C₉H₁₀BrN
• 分子量: 212.089
• InChiKey: AKVBYYMULNIGLH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-氨基-7-溴茚满盐酸盐 在 2-双环己基膦-2',6'-二甲氧基联苯 、 1,1'-双(二苯基膦)二茂铁 、 palladium diacetate 、 三乙胺 、 cesium fluoride 作用下， 以 四氢呋喃 、 1,4-二氧六环 为溶剂， 反应 29.33h， 生成 ethyl 3-(3-(tert-butoxycarbonylamino)-2,3-dihydro-1H-inden-4-yl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate
  参考文献：
  名称：

  Rigid Analogues of Antimitotic Indolobenzazepinones: New Insights into Tubulin Binding via Molecular Modeling

  摘要：

  Two rigid analogues of 5-ethylindolobenzazepinone 4, a potent c-ytotoxic agent and inhibitor of tubulin polymerization, were prepared. The first was the indane derivative 5, in which the ethyl group is attached to the benzo moiety. The second was the pyrrolidine analogue 6, in which the ethyl chain was bound to the lactam nitrogen. While both compounds were considerably less active inhibitors of KB cell growth as compared to 4, inhibition of tubulin polymerization was only moderately reduced. Tubulin docking studies indicated that the aR and aS atropoisomers of 5 and 6 occupy different binding pockets at the colchicine binding site. Conversely, both aS-5 and aS-6 occupy the same binding pocket as aSS-4 but do not benefit from the favorable hydrophobic interactions provided by the CS alkyl group of 4, thus possibly explaining their lower activities.

  DOI：

  10.1021/ml200024y
• 作为产物：
  描述：

  7-溴-1-茚满酮 在 ammonium acetate 、 sodium cyanoborohydride 作用下， 以 乙醇 为溶剂， 反应 0.03h， 以83%的产率得到1-氨基-7-溴茚满盐酸盐
  参考文献：
  名称：

  Microwave-accelerated reductive amination between ketones and ammonium acetate

  摘要：

  A new procedure for reductive amination between ketones and ammonium acetate has been developed to access a variety of primary amines. This protocol takes advantage of microwave heating to significantly accelerate the reaction and offers a convenient and effective method to access some interesting amines. This new procedure compares favorably to previously reported approaches in terms of practicality, efficiency, and functional group compatibility. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.07.156

文献信息

• [EN] INDANE AND INDOLINE DERIVATIVES AND THE USE THEREOF AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS<br/>[FR] DÉRIVÉS D'INDANE ET D'INDOLINE ET LEUR UTILISATION EN TANT QU'ACTIVATEURS DE LA GUANYLATE CYCLASE SOLUBLE
  申请人：NOVARTIS AG

  公开号：WO2016001875A1

  公开（公告）日：2016-01-07

  The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了化合物(I)或其药学上可接受的盐；制造本发明化合物的方法及其治疗用途。本发明还提供了药理活性剂的组合和制药组合物。
• SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS
  申请人：Chow Ken

  公开号：US20080255239A1

  公开（公告）日：2008-10-16

  Therapeutic compounds, and methods, compositions, and medicaments related thereto are disclosed herein.

  本文揭示了治疗化合物、方法、组合物和相关药物。
• METHODS FOR MAKING QUINOLINYLDIAMINES
  申请人：ExxonMobil Chemical Patents Inc.

  公开号：US20200071344A1

  公开（公告）日：2020-03-05

  The present disclosure provides methods for making quinolinyldiamine products from quinolinyl starting materials. In addition, the quinolinyldiamines can be used as ligands or ligand precursors for catalysts, e.g. for use in olefin polymerization.

  本公开提供了一种从喹啉基起始材料制备喹啉二胺产品的方法。此外，这些喹啉二胺可以用作配体或催化剂的前体，例如用于烯烃聚合反应。
• THERAPEUTIC FLUOROETHYLCYANO GUANIDINES
  申请人：Chow Ken

  公开号：US20080255230A1

  公开（公告）日：2008-10-16

  Disclosed herein is compound having a formula as described herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.

  本文披露了具有如本文所述的化学式的化合物。还披露了与之相关的治疗方法、组成和药物。
• [EN] HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS<br/>[FR] DÉRIVÉS D'AMIDE HÉTÉROCYCLIQUE COMME ANTAGONISTES DU RÉCEPTEUR P2X7
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2013108227A1

  公开（公告）日：2013-07-25

  The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, X and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.

  该发明涉及式（I）的杂环酰胺衍生物，其中R1、R2、R3、X和n如描述中所定义，其制备以及它们作为药用活性化合物的用途。