1-氯-2-(2-氯乙氧基甲氧基甲氧基)乙烷 | 73131-00-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-氯-2-(2-氯乙氧基甲氧基甲氧基)乙烷
• 英文名称: bis-(2-chloro-ethoxymethyl) ether
• 英文别名: 1-Chloro-2-{[(2-chloroethoxy)methoxy]methoxy}ethane；1-chloro-2-(2-chloroethoxymethoxymethoxy)ethane
• CAS: 73131-00-7
• 化学式: C₆H₁₂Cl₂O₃
• 分子量: 203.065
• InChiKey: SXVLNMXFQJCPJQ-UHFFFAOYSA-N

物化性质

• 沸点：
  237.8±25.0 °C(Predicted)
• 密度：
  1.198±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  11
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 2-氯乙醇 在 碘 作用下， 生成 1-氯-2-(2-氯乙氧基甲氧基甲氧基)乙烷
  参考文献：
  名称：

  838.缩醛和低聚缩醛。第一部分：反应性寡聚甲醛的制备和性质

  摘要：

  DOI：

  10.1039/jr9620004307

文献信息

• [EN] TRIAZOLE COMPOUNDS USEFUL IN TREATING DISEASES ASSOCIATED WITH UNWANTED CYTOKINE ACTIVITY<br/>[FR] COMPOSES TRIAZOLE CONVENANT POUR LE TRAITEMENT DE MALADIES ASSOCIEES A L'ACTIVITE INDESIRABLE DES CYTOKINES
  申请人：PROCTER & GAMBLE

  公开号：WO2002088108A1

  公开（公告）日：2002-11-07

  The present invention relates to 4-aryl triazoles having the formula: wherein R1 is independently selected from the group consisting of: lower alkyl, lower alkenyl, lower alkynyl, lower heteroalkyl, lower heteroalkenyl, lower heteroalkynyl, heterocycloalkyl, heteroaryl, halo, CN, OR4, SR4, S(O)R4, S(O)2R4, and NR4R5; and Q is has the general formula: or said compounds are useful in treating diseases associated with unwanted cytokine activity, inter alia, interleukin-1 (IL-1) and tumor necrosis factor (TNF) from cells.

  本发明涉及具有以下式的4-芳基三唑：其中R1独立地选自以下组中的一种：低烷基，低烯基，低炔基，低杂原烷基，低杂原烯基，低杂原炔基，杂环烷基，杂环芳基，卤素，CN，OR4，SR4，S（O）R4，S（O）2R4和NR4R5；Q具有以下通式：或者说这些化合物在治疗与不必要的细胞因子活性相关的疾病方面有用，例如白细胞介素-1（IL-1）和肿瘤坏死因子（TNF）。
• [EN] HYDROXYL COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES<br/>[FR] COMPOSES HYDROXYLES ET COMPOSITIONS DE REGULATION DU CHOLESTEROL ET UTILISATIONS ASSOCIEES
  申请人：ESPERION THERAPEUTICS INC

  公开号：WO2004067489A2

  公开（公告）日：2004-08-12

  The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

  本发明涉及新型羟基化合物、包含羟基化合物的组合物和用于治疗和预防各种疾病和病症的方法，例如但不限于老化、阿尔茨海默病、癌症、心血管疾病、糖尿病肾病、糖尿病视网膜病变、葡萄糖代谢紊乱、脂质代谢紊乱、高血压、阳痿、炎症、胰岛素抵抗、胆汁中脂质消除、肥胖症、胆汁中氧化固醇消除、胰腺炎、帕金森病、过氧化物酶体增殖物激活受体相关疾病、胆汁中磷脂消除、肾脏疾病、败血症、代谢综合征（例如综合征X）、血栓性疾病。本发明的化合物和方法还可用于调节C反应蛋白或增强患者的胆汁产生。在某些实施例中，本发明的化合物、组合物和方法可与其他治疗药物（如降胆固醇和降血糖药物）联合使用。
• [EN] ETHER COMPOUNDS, COMPOSITIONS, AND USES THEREOF<br/>[FR] COMPOSES D'ETHER, COMPOSITIONS ET LEURS UTILISATIONS
  申请人：ESPERION THERAPEUTICS INC

  公开号：WO2000059855A1

  公开（公告）日：2000-10-12

  The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

  本发明涉及新型醚化合物、包含醚化合物的组合物及其用于治疗和预防心血管疾病、血脂异常、蛋白异常和葡萄糖代谢障碍的方法，包括给予含有醚化合物的组合物。本发明的化合物、组合物和方法还可用于治疗和预防阿尔茨海默病、X综合征、过氧化物酶体增殖物激活受体相关疾病、败血症、血栓性疾病、肥胖症、胰腺炎、高血压、肾脏疾病、癌症、炎症和阳痿。在某些实施例中，本发明的化合物、组合物和方法与其他治疗药物（如降胆固醇和降血糖药物）的联合治疗也是有用的。
• Triazole compounds useful in treating diseases associated with unwanted cytokine activity
  申请人：——

  公开号：US20030013712A1

  公开（公告）日：2003-01-16

  The present invention relates to 4-aryl triazoles having the formula: 1 wherein R 1 is independently selected from the group consisting of: lower alkyl, lower alkenyl, lower alkynyl, lower heteroalkyl, lower heteroalkenyl, lower heteroalkynyl, heterocycloalkyl, heteroaryl, halo, CN, OR 4 , SR 4 , S(O)R 4 , S(O) 2 R 4 , and NR 4 R 5 ; and Q is has the general formula: 2 said compounds are useful in treating diseases associated with unwanted cytokine activity, inter alia, interleukin-1 (IL-1) and tumor necrosis factor (TNF) from cells.

  本发明涉及具有以下式子的4-芳基三唑：1其中R1独立地选自以下组：低烷基，低烯基，低炔基，低杂原烷基，低杂原烯基，低杂原炔基，杂环烷基，杂环芳基，卤素，CN，OR4，SR4，S（O）R4，S（O）2R4和NR4R5; Q具有一般式：2所述化合物在治疗与细胞中不需要的细胞因子活性相关的疾病中有用，包括白细胞介素-1（IL-1）和肿瘤坏死因子（TNF）。
• Gubaidullin. L. Yu.; Chugunov, Yu. V.; Ioffe, D. S., Russian Journal of Applied Chemistry, 1996, vol. 69, # 1, p. 153 - 154
  作者：Gubaidullin. L. Yu.、Chugunov, Yu. V.、Ioffe, D. S.、Gubaidullin, I. L.、Tyut'ko, K. A.、et al.

  DOI：——

  日期：——