1-环己基-5-苯基咪唑 | 71333-68-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 1-环己基-5-苯基咪唑
• 英文名称: 1-cyclohexyl-5-phenyl-1H-imidazole
• 英文别名: 1-cyclohexyl-5-phenyl imidazole；1-cyclohexyl-5-phenylimidazole；1-cyclohexyl-5-phenyl-1H-imidazole；1-Cyclohexyl-5-phenylimidazol
• CAS: 71333-68-1
• 化学式: C₁₅H₁₈N₂
• 分子量: 226.321
• InChiKey: RJAUJRNONCTRPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-溴苯乙酮 在 氢氧化钾 、 对甲苯磺酸 作用下， 以 甲醇 、 xylene 为溶剂， 反应 12.0h， 生成 1-环己基-5-苯基咪唑
  参考文献：
  名称：

  The chemical simulation of the “atp-imidazole” cycle

  摘要：

  DOI：

  10.1016/s0040-4020(01)87289-6

文献信息

• Synthesis on templates : Regiospecific synthesis of imidazoles
  作者：Darshan Ranganathan、Firdous Farooqui

  DOI：10.1016/s0040-4039(01)91416-9

  日期：1984.1

  A new, biomimetic template operated strategy has been developed leading to regiospecific synthesis of imidazoles (CHARTS I & II).

  已开发出一种新的仿生模板操作策略，该策略可导致咪唑的区域特异性合成（图I和II）。
• Converting oxazoles into imidazoles: new opportunities for diversity-oriented synthesis
  作者：Thibaut Alzieu、Johannes Lehmann、Ajay B. Naidu、Rainer E. Martin、Robert Britton

  DOI：10.1039/c3cc48467j

  日期：——

  We report the optimization of a neglected reaction for the rapid and direct conversion of oxazoles into N-substituted imidazoles. The utility of this microwave-promoted reaction for diversity-oriented synthesis is demonstrated in the preparation of >40 N-substituted imidazoles, including alpha-imidazolyl esters.

  我们报告了快速和直接将恶唑转化为N-取代的咪唑的被忽视反应的优化。微波促进反应在面向多样性的合成中的实用性在包括α-咪唑基酯在内的> 40种N-取代的咪唑的制备中得到了证明。
• Synthesis on templates II : Directed synthesis of imidazoles from adenine
  作者：Darshan Ranganathan、Firdous Farooqui、Dipti Bhattacharyya

  DOI：10.1016/s0040-4039(00)98868-3

  日期：1985.1

  Adenine has been used as the template for the directed synthesis of 5-substituted imidazoles. A Novel intermediate involved in the cyclic operation has been characterised.

  腺嘌呤已被用作直接合成5-取代的咪唑的模板。表征了涉及循环操作的新型中间体。
• Isocyanoalkenes, process and useful intermediates for their preparation, pharmaceutical and fungicidal preparations containing those isocyanoalkenes and the use of the fungicidal preparations in agriculture
  申请人：GIST-BROCADES N.V.

  公开号：EP0007672A1

  公开（公告）日：1980-02-06

  Isocysnoalksnes, process and useful intermediates for their preparation, pharmaceutical and fungicidal preparations containing those isocyanoalkenes and the use of the fungicidal preparations in agriculture, the isocyanoalkenes having the general formula: wherein Rx and Ry are the same or different and each is a hydrogen atom or an alkyl, aryl or heterocyclic group and Rx and Ry together with the carbon atom to which they are attached represent a homo- or heterogeneous cydoal- kylidene, adamantylidene or cholestamtlidene group, Rw is an alkylidene group or Rw together with Rx and the carbon atom to which they are attached represent a homo- or heterogeneous cycloalkenyl group and Rz is an aryl group.

  异氰基烯烃、制备它们的工艺和有用中间体、含有这些异氰基烯烃的药物和杀菌制剂以及这些杀菌制剂在农业中的用途，这些异氰基烯烃具有通式： 其中 Rx 和 Ry 相同或不同，且各自为氢原子或烷基、芳基或杂环基团，Rx 和 Ry 与它们所连接的碳原子一起代表同族或异族的亚烷基、亚金刚烷基或亚胆烷基，Rw 为亚烷基或 Rw 与 Rx 和它们所连接的碳原子一起代表同族或异族的环烯基，Rz 为芳基。
• RANGANATHAN, DARSHAN;FAROOQUI, FIRDOUS, TETRAHEDRON LETT., 1984, 25, N 49, 5701-5704
  作者：RANGANATHAN, DARSHAN、FAROOQUI, FIRDOUS

  DOI：——

  日期：——