1-甲基丁-1-烯-1,2,4-三羧酸 | 577-53-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 1-甲基丁-1-烯-1,2,4-三羧酸
• 英文名称: Pent-3-ene-1,3,4-tricarboxylic acid
• 英文别名: 1-methylbut-1-ene-1,2,4-tricarboxylic acid
• CAS: 577-53-7
• 化学式: C₈H₁₀O₆
• 分子量: 202.164
• InChiKey: GDSOZVZXVXTJMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-甲基丁-1-烯-1,2,4-三羧酸 在 盐酸 作用下， 以 水 为溶剂， 以340 mg的产率得到2,5-二羟基-4-甲基-2,5-二氧代-3-呋喃丙酸
  参考文献：
  名称：

  Enzymatic synthesis of a 6-sialyl lactose analogue using a pH-responsive water-soluble polymer support

  摘要：

  The Letter describes a strategy for the enzymatic synthesis of glycans based on a pH-responsive water-soluble polymer. In neutral condition, the polymer is water-soluble and convenient for in-solution enzymatic synthesis, whereas in acidic condition (pH lower than 4.0), the polymer disconnects with the product and becomes insoluble, which can be easily removed. A 6-Sialyl lactose analogue was synthesized as a model reaction using this approach. (C) 2011 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2011.04.076
• 作为产物：
  描述：

  2-氧代戊烷-1,5-二甲酸二乙酯 在 sodium hydride 、 potassium hydroxide 作用下， 以 四氢呋喃 、 乙醇 、 mineral oil 为溶剂， 反应 2.5h， 生成 1-甲基丁-1-烯-1,2,4-三羧酸
  参考文献：
  名称：

  Enzymatic synthesis of a 6-sialyl lactose analogue using a pH-responsive water-soluble polymer support

  摘要：

  The Letter describes a strategy for the enzymatic synthesis of glycans based on a pH-responsive water-soluble polymer. In neutral condition, the polymer is water-soluble and convenient for in-solution enzymatic synthesis, whereas in acidic condition (pH lower than 4.0), the polymer disconnects with the product and becomes insoluble, which can be easily removed. A 6-Sialyl lactose analogue was synthesized as a model reaction using this approach. (C) 2011 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2011.04.076

文献信息

• Enzymatic synthesis of a 6-sialyl lactose analogue using a pH-responsive water-soluble polymer support
  作者：Wenjun Wang、Lei Li、Chen Jin、Yujie Niu、Sen Li、Ji Ma、Linfeng Li、Yu Liu、Li Cai、Wei Zhao、Peng George Wang

  DOI：10.1016/j.bmcl.2011.04.076

  日期：2011.9

  The Letter describes a strategy for the enzymatic synthesis of glycans based on a pH-responsive water-soluble polymer. In neutral condition, the polymer is water-soluble and convenient for in-solution enzymatic synthesis, whereas in acidic condition (pH lower than 4.0), the polymer disconnects with the product and becomes insoluble, which can be easily removed. A 6-Sialyl lactose analogue was synthesized as a model reaction using this approach. (C) 2011 Published by Elsevier Ltd.