1-碘甲基-1-环己醇 | 107535-41-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-碘甲基-1-环己醇
• 英文名称: 1-Iodomethylcyclohexanol
• 英文别名: 1-(Iodomethyl)cyclohexan-1-ol
• CAS: 107535-41-1
• 化学式: C₇H₁₃IO
• 分子量: 240.084
• InChiKey: OKIIOMJZFIPEKS-UHFFFAOYSA-N

物化性质

• 熔点：
  70.4 °C(Solv: hexane (110-54-3))
• 沸点：
  265.2±13.0 °C(Predicted)
• 密度：
  1.693±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  亚甲基环己烷 在 N-碘代丁二酰亚胺 、 水 作用下， 以 various solvent(s) 为溶剂， 反应 1.5h， 以96%的产率得到1-碘甲基-1-环己醇
  参考文献：
  名称：

  Green approach for the conversion of olefins into vic-halohydrins using N-halosuccinimides in ionic liquids

  摘要：

  Alkenes undergo smooth bromo- and iodohydroxylation with N-bromo- and N-iodosuccinimides/water, respectively, using the air and moisture stable ionic liquid [bmim]BF4 as a novel recyclable reaction medium in high to quantitative yields. N-Halosuccinimides show enhanced reactivity in ionic liquids thereby reducing the reaction times and improving the yields considerably. (c) 2005 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2005.03.108

文献信息

• [EN] GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE<br/>[FR] INHIBITEURS DE GLYCOLATE OXYDASE POUR LE TRAITEMENT D'UNE MALADIE
  申请人：BIOMARIN PHARM INC

  公开号：WO2020257487A1

  公开（公告）日：2020-12-24

  Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with a defect in glyoxylate metabolism, for example a disease or disorder associated with the enzyme glycolate oxidase (GO) or alterations in oxalate metabolism. Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

  本文描述了化合物、制备这种化合物的方法、含有这种化合物的药物组合物和药物，以及使用这种化合物治疗或预防与甘氧酸代谢缺陷相关的疾病或紊乱的方法，例如与甘氧酸氧化酶（GO）或草酸代谢变化相关的疾病或紊乱。这些疾病或紊乱包括与产生过多草酸相关的甘氧酸代谢紊乱，例如原发性高草酸尿症。
• The reaction of carbonyl compounds with diiodomethane in the presence of samarium: Novel syntheses of iodohydrins and cyclopropanols
  作者：Tsuneo Imamoto、Toshiaki Takeyama、Hiroyasu Koto

  DOI：10.1016/s0040-4039(00)84764-4

  日期：1986.1

  The iodomethylation of carbonyl compounds giving iodohydrins has been achieved under ordinary conditions by the use of diiodomethane and samarium. A novel synthesis of cyclopropanols from α-haloketones or 1,2-dibenzoylethane is also described.

  在通常条件下，通过使用二碘甲烷和sa可以实现羰基化合物的碘甲基化，从而得到碘醇。还描述了由α-卤代酮或1，2-二苯甲酰基乙烷新型合成环丙醇。
• [EN] PYRIMIDINE CARBOXAMIDES AS SODIUM CHANNEL BLOCKERS<br/>[FR] PYRIMIDINE CARBOXAMIDES À TITRE DE BLOQUEURS DES CANAUX SODIQUES
  申请人：PURDUE PHARMA LP

  公开号：WO2014135955A1

  公开（公告）日：2014-09-12

  The present disclosure provides substituted pyrimidine carboxamides of Formula (I) and the pharmaceutically acceptable salts and solvates thereof, wherein A1, X, A2, W1, W2, W3, E, Z, and R4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.

  本公开提供了公式（I）的取代嘧啶羧酰胺及其在药学上可接受的盐和溶剂化合物，其中A1、X、A2、W1、W2、W3、E、Z和R4的定义如规范中所述。本公开还涉及使用公式（I）的化合物治疗对钠通道阻断有反应的疾病。本公开的化合物特别适用于治疗疼痛。
• [EN] PYRIMIDINES AS SODIUM CHANNEL BLOCKERS<br/>[FR] PYRIMIDINES UTILISÉES COMME BLOQUEURS DE CANAUX SODIQUES
  申请人：PURDUE PHARMA LP

  公开号：WO2013030665A1

  公开（公告）日：2013-03-07

  The present disclosure provides substituted pyrimidine compounds of Formula (I), and the pharmaceutically acceptable salts, prodrugs, and solvates thereof, wherein A1, X, A2, W1, W2, W3, E, Z, and R4 are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.

  本公开提供了式（I）的取代嘧啶化合物，以及其药用可接受的盐、前药和溶剂化合物，其中A1、X、A2、W1、W2、W3、E、Z和R4的定义如规范中所述。本公开还涉及使用式（I）的化合物来治疗对钠通道阻滞有响应的疾病。本公开的化合物特别适用于治疗疼痛。
• Very Rapid Preparation of SmI2 by Sonic Treatment of Iodoform and Metallic Samarium
  作者：José M. Concellón、Humberto Rodríguez-Solla、Eva Bardales、Mónica Huerta

  DOI：10.1002/ejoc.200210669

  日期：2003.5

  A very rapid preparation of SmI2 by sonication of a mixture of metallic samarium and iodoform in THF is described. To prove the synthetic applications of the obtained SmI2 several high-yielding reactions were carried out. Preliminary results for the generation of SmI2 in THF by sonication from diiodomethane, 1,2-diiodoethane, or iodine are also described. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451

  描述了通过在 THF 中对金属钐和碘仿的混合物进行超声处理来非常快速地制备 SmI2。为了证明所获得的 的合成应用，进行了几个高产率反应。还描述了通过超声处理从二碘甲烷、1,2-二碘乙烷或碘在 THF 中生成 的初步结果。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)