1-脱氧-1-(甲基氨基)六糖醇-己-1-烯桥呋喃糖-3-酮糖(1:1) | 17146-87-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-脱氧-1-(甲基氨基)六糖醇-己-1-烯桥呋喃糖-3-酮糖(1:1)
• 英文名称: Methylglucamine ascorbate
• 英文别名: (2R)-2-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxy-2H-furan-5-one;(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol
• CAS: 17146-87-1
• 化学式: C13H25NO11
• 分子量: 371.34
• InChiKey: WOPGPABMXQSCHS-PSIKLALISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.77
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  220
• 氢给体数：
  10
• 氢受体数：
  12

文献信息

• Contrast agents for magnetic resonance imaging
  申请人：Duke University

  公开号：US10111970B2

  公开（公告）日：2018-10-30

  Ascorbate or a pharmaceutically acceptable salt thereof is described for use in carrying out a method, or for the preparation of a medicament for carrying out a method, of enhancing a magnetic resonance imaging (MRI) image of a body or body region such as an organ or organ region in a subject. The method is carried out by parenterally administering ascorbate or a pharmaceutically acceptable salt thereof to the subject in an MRI image-enhancing amount; and then generating, by MRI of the subject, an image of the body or body region. The ascorbate or pharmaceutically acceptable salt thereof enhances the MRI image.

  本发明描述了抗坏血酸或其药学上可接受的盐，用于实施一种方法或制备一种用于实施方法的药物，以增强受试者身体或身体区域（如器官或器官区域）的磁共振成像（MRI）图像。该方法通过向受试者肠外给予一定量的抗坏血酸盐或其药学上可接受的盐，以增强核磁共振成像；然后通过受试者的核磁共振成像生成身体或身体区域的图像。抗坏血酸或其药学上可接受的盐可增强核磁共振成像。
• Ascorbate formulations and methods of use as contrast agents
  申请人：Duke University

  公开号：US10286089B2

  公开（公告）日：2019-05-14

  A sterile aqueous composition suitable for use as an MRI contrast agent includes 100 to 600 mM ascorbate; and 100-600 mM sodium, meglumine, or a combination thereof. The composition preferably has an osmolarity of 200 to 1400 mOsm/L.

  适合用作核磁共振成像造影剂的无菌水溶液组合物包括 100 至 600 毫摩尔抗坏血酸；以及 100-600 毫摩尔钠、巨霉素或它们的组合。组合物的渗透压最好为 200 至 1400 mOsm/L。
• ASCORBATE FORMULATIONS AND METHODS OF USE AS CONTRAST AGENTS
  申请人：Duke University

  公开号：EP3183008A1

  公开（公告）日：2017-06-28
• CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING
  申请人：Laderx LLC

  公开号：EP3183009A1

  公开（公告）日：2017-06-28
• Contrast Agents for Magnetic Resonance Imaging
  申请人：Duke University

  公开号：US20170189559A1

  公开（公告）日：2017-07-06

  Ascorbate or a pharmaceutically acceptable salt thereof is described for use in carrying out a method, or for the preparation of a medicament for carrying out a method, of enhancing a magnetic resonance imaging (MRI) image of a body or body region such as an organ or organ region in a subject. The method is carried out by parenterally administering ascorbate or a pharmaceutically acceptable salt thereof to the subject in an MRI image-enhancing amount; and then generating, by MRI of the subject, an image of the body or body region. The ascorbate or pharmaceutically acceptable salt thereof enhances the MRI image.