1-(3-acetylphenyl)sulfonyl-N-[(2-fluorophenyl)methyl]piperidine-4-carboxamide

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(3-acetylphenyl)sulfonyl-N-[(2-fluorophenyl)methyl]piperidine-4-carboxamide
• 化学式: C₂₁H₂₃FN₂O₄S
• 分子量: 418.5
• InChiKey: CQACRIPCMZWOGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  91.9
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• INHIBITOR OF CITRATE TRANSPORTER AND THEIR USE IN THERAPY
  申请人：Eternygen GmbH

  公开号：US20200087258A1

  公开（公告）日：2020-03-19

  The present invention relates to a compound of general formula (I) for use in treating diseases depending on the activity of a citrate transporter, wherein the compound has the general formula (I) wherein R1 is Aryl, substituted aryl, styryl, or bicyclic; V is SO 2 ; W is N with n and n1 are 1 and X is C═O, or W is C with n and n1 are 0 or 1 and X is CH 2 or C═O, Y is N—H or N-methyl and R2 is benzyl, substituted benzyl or CH 2 (2-pyridyl). Further, it relates to the use of a compound of general formula (I) for preparing a medicament and its use for the treatment of obesity and diabetes, in particular type 2 diabetes and other metabolic diseases as well as for the treatment of age related diseases.