15,15-二甲基-2,5,8,11,14-五氧杂十六烷 | 53627-29-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 15,15-二甲基-2,5,8,11,14-五氧杂十六烷
• 英文名称: 15,15-Dimethyl-2,5,8,11,14-pentaoxahexadecane
• 英文别名: 2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]-2-methylpropane
• CAS: 53627-29-5
• 化学式: C₁₃H₂₈O₅
• 分子量: 264.36
• InChiKey: JUVLNFFZRNEVSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  18
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• Verfahren zur Herstellung von Kronenethern
  申请人：Consortium für elektrochemische Industrie GmbH

  公开号：EP0176076A1

  公开（公告）日：1986-04-02

  Die Erfindung betrifft ein Verfahren zur Herstellung von makrocyclischen Polyethern durch Cyclisieren von a, w-Diolen mit α,ω-Dichloriden oder durch Cyclisieren von a,w-Chlorhydrinen in Gegenwart von Kaliumhydroxid und Dimethylsulfoxid, wobei die Cyclisierungsreaktion in Gegenwart von 18 bis 50 Gew.-% bezogen auf das Gesamtgewicht des Gemisches Wasser/Dimethylsulfoxid/Kaliumhydroxid, an Wasser durchgeführt wird, das zusätzlich zu ggf. bei der Cyclisierungsreaktion gebildetem Wasser dem Reaktionsgemisch zugeführt wurde.

  本发明涉及一种通过 a,w-二醇与α,ω-二氯的环化反应或通过 a,w-氯醇在氢氧化钾和二甲基亚砜存在下的环化反应制备大环聚醚的工艺，其中环化反应是在水/二甲基亚砜/氢氧化钾混合物总重量的 18%至 50%（以重量计）的水存在下进行的，除了在环化反应过程中形成的任何水之外，还有加入到反应混合物中的水。以水/二甲基亚砜/氢氧化钾混合物的总重量为基准，添加到反应混合物中的水的 重量百分比，不包括在循环反应过程中形成的任何水。
• Novel cc-1065 Analogs and Their Conjugates
  申请人：Beusker Patrick Henry

  公开号：US20110207767A1

  公开（公告）日：2011-08-25

  This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.
• NOVEL CONJUGATES OF CC-1065 ANALOGS AND BIFUNCTIONAL LINKERS
  申请人：Beusker Patrick Henry

  公开号：US20130224227A1

  公开（公告）日：2013-08-29

  This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.
• Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers
  申请人：SYNTARGA BV

  公开号：US20170274090A1

  公开（公告）日：2017-09-28

  This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.
• US4088590A
  申请人：——

  公开号：US4088590A

  公开（公告）日：1978-05-09