1H-咪唑,4-苯氧基- | 104672-19-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1H-咪唑,4-苯氧基-
• 英文名称: 4(5)-phenoxyimidazole
• 英文别名: 5-phenoxy-1H-imidazole
• CAS: 104672-19-7
• 化学式: C₉H₈N₂O
• 分子量: 160.175
• InChiKey: PCRODLZZZPRWHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-重氮咪唑 、 苯甲醚 以14%的产率得到
  参考文献：
  名称：

  AMICK, T. J.;SHECHTER, H., TETRAHEDRON LETT., 1986, 27, N 8, 901-904

  摘要：

  DOI：

文献信息

• Method of treating cancer
  申请人：Rosen Neal

  公开号：US20050137207A1

  公开（公告）日：2005-06-23

  The present invention relates to methods of treating cancer using a combination of a compound which is an antineoplastic agent and a compound which is a inhibitor of prenyl-protein transferase, which methods comprise administering to said mammal, either sequentially in any order or simultaneously, amounts of at least two therapeutic agents selected from a group consisting of a compound which is an antineoplastic agent and a compound which is a inhibitor of prenyl-protein transferase. The invention also relates to methods of preparing such compositions.

  本发明涉及使用一种抗肿瘤剂和一种前尼蛋白转移酶抑制剂的组合治疗癌症的方法，该方法包括向所述哺乳动物施用来自以下组中至少两种治疗剂的量，所述组包括一种抗肿瘤剂和一种前尼蛋白转移酶抑制剂，所述治疗剂可以按任何顺序依次或同时施用。该发明还涉及制备这种组合物的方法。
• N-(Phenoxyalkyl) carboxamides and their use as antiarrhythmic agents
  申请人：American Cyanamid Company

  公开号：EP0792873A1

  公开（公告）日：1997-09-03

  The present invention relates to substituted ω-[phenoxy, phenylthio, phenylsulfinyl, phenylsulfonyl] [alkyl, alkenyl or alkynyl]amine carboxamides, sulfonamides and phosphonylamides which are useful as antiarrhythmic agents.

  本发明涉及替代的ω-[苯氧基、苯硫基、苯亚硫基、苯砜基][烷基、烯基或炔基]胺羧酰胺、磺胺和磷酰胺，其作为抗心律失常药物具有用途。
• Carbenic reactions of 4-diazo-4-imidazole with benzene derivatives
  作者：T.J. Amick、H. Shechter

  DOI：10.1016/s0040-4039(00)84132-5

  日期：1986.1

  The electrophilic behavior of 4H-imidazolylidene is greatly modified by coordinating groups in benzene derivatives undergoing substitution.

  4H-咪唑基亚烷基的亲电子行为可通过配位进行取代的苯衍生物中的基团大大改变。
• [EN] A METHOD OF TREATING ENDOMETRIOSIS<br/>[FR] PROCEDE POUR TRAITER L'ENDOMETRIOSE
  申请人：MERCK & CO INC

  公开号：WO2000025789A1

  公开（公告）日：2000-05-11

  A method of preventing and treating endometriosis, uterine fibroids, dysfunctional uterine bleeding and endometrial hyperplasia is disclosed which is comprised of administering to a mammalian patient in need of such treatment an effective amount of a prenyl-protein transferase inhibitor.

  本发明揭示了一种预防和治疗子宫内膜异位症、子宫肌瘤、功能性子宫出血和子宫内膜增生的方法，包括向需要此类治疗的哺乳动物患者投予有效量的戊二酰基-蛋白转移酶抑制剂。
• INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
  申请人：MERCK & CO., INC.

  公开号：EP0862435A1

  公开（公告）日：1998-09-09