2'-苯胺基-6'-(二乙胺基)-3'-甲氧基螺[异苯并呋喃-1(3H)-9'[9H]-占吨]-3-酮 | 82773-20-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 中文名称: 2'-苯胺基-6'-(二乙胺基)-3'-甲氧基螺[异苯并呋喃-1(3H)-9'[9H]-占吨]-3-酮
• 英文名称: O⁶-Isopropylguanosin
• 英文别名: O⁶-isopropyl-guanosine；O-Isopropylguanosine；(2R,3R,4S,5R)-2-(2-amino-6-propan-2-yloxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
• CAS: 82773-20-4
• 化学式: C₁₃H₁₉N₅O₅
• 分子量: 325.324
• InChiKey: WGBLLRVMAHKTDI-WOUKDFQISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  149
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• Optimized oncolytic viruses and uses thereof
  申请人：Sator Therapeutics LLC

  公开号：US11253558B2

  公开（公告）日：2022-02-22

  Methods of inhibiting or reducing tumor growth are disclosed. A composition containing at least one selected oncolytic virus is administered within a tumor of a patient. The virus kills cancerous cells and induces a systemic and lasting anti-tumor immunity that is also compatible with other cancer treatments. Also disclosed are methods of creating synthetic viruses for targeting cancerous tumors.

  本研究公开了抑制或减少肿瘤生长的方法。一种含有至少一种精选溶瘤病毒的组合物被注射到患者的肿瘤内。该病毒可杀死癌细胞，诱导全身性持久抗肿瘤免疫力，并可与其他癌症治疗方法相容。此外，还公开了针对癌症肿瘤的合成病毒的制造方法。
• Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA
  申请人：Loeb A. Lawrence

  公开号：US20050187180A1

  公开（公告）日：2005-08-25

  The present invention is directed to the identification and use of ribonucleoside analogs to induce the mutation of an RNA virus, including BVDV, HIV and HCV, or a virus which otherwise replicates through an RNA intermediate. The increase in the mutation rate of the virus results in reduced viability of progeny generations of the virus, thereby inhibiting viral replication. In addition to these methods and related compositions, the invention provides methods and combinatorial chemistry libraries for screening ribonucleoside analogs for mutagenic potential.

  本发明涉及核糖核苷类似物的鉴定和使用，以诱导 RNA 病毒（包括 BVDV、HIV 和 HCV）或以其他方式通过 RNA 中间体复制的病毒发生变异。病毒变异率的增加会导致病毒后代的存活率降低，从而抑制病毒复制。除了这些方法和相关组合物之外，本发明还提供了筛选核糖核苷类似物诱变潜力的方法和组合化学文库。
• CONTINUOUS DIRECTED EVOLUTION OF PROTEINS AND NUCLEIC ACIDS
  申请人：President and Fellows of Harvard College

  公开号：EP2342336B1

  公开（公告）日：2016-12-14
• OPTIMIZED ONCOLYTIC VIRUSES AND USES THEREOF
  申请人：Sator Therapeutics LLC

  公开号：EP3518947A1

  公开（公告）日：2019-08-07
• US9023594B2
  申请人：——

  公开号：US9023594B2

  公开（公告）日：2015-05-05