2(2-羟基乙氧基)乙酰胺 | 123-85-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2(2-羟基乙氧基)乙酰胺
• 中文别名: 2-(2-羟基乙氧基)乙酰胺
• 英文名称: 2-(2-hydroxyethoxy)-acetamide
• 英文别名: 2-(2-hydroxyethoxy)acetamide；hydroxyethoxy acetamide；O-(2-Hydroxyaethyl)glycolamid；(2-Hydroxy-ethoxy)-acetamid
• CAS: 123-85-3
• 化学式: C₄H₉NO₃
• mdl: MFCD00047894
• 分子量: 119.12
• InChiKey: INNWRDCESBMSQK-UHFFFAOYSA-N

物化性质

• 熔点：
  83-84 °C(Solv: chloroform (67-66-3))
• 沸点：
  338.6±22.0 °C(Predicted)
• 密度：
  1.200±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2924199090

SDS

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SECTION 1: Identification of the substance/mixture and of the company/undertaking
Product identifiers
Product name : O-(2-HYDROXYETHYL)-GLYCOLAMIDE
REACH No. : A registration number is not available for this substance as the substance
or its uses are exempted from registration, the annual tonnage does not
require a registration or the registration is envisaged for a later
registration deadline.
CAS-No. : 123-85-3
Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances

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SECTION 2: Hazards identification
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Eye irritation (Category 2), H319
For the full text of the H-Statements mentioned in this Section, see Section 16.
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Xi Irritant R36
For the full text of the R-phrases mentioned in this Section, see Section 16.
Label elements
Labelling according Regulation (EC) No 1272/2008
Pictogram
Signal word Warning
Hazard statement(s)
H319 Causes serious eye irritation.
Precautionary statement(s)
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
Supplemental Hazard none
Statements
Other hazards - none

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SECTION 3: Composition/information on ingredients
Substances
Formula : C4H9NO3
Molecular Weight : 119,12 g/mol
CAS-No. : 123-85-3
Hazardous ingredients according to Regulation (EC) No 1272/2008
Component Classification Concentration
O-(2-HYDROXYETHYL)-GLYCOLAMIDE
CAS-No. 123-85-3 Eye Irrit. 2; H319 <= 100 %
Hazardous ingredients according to Directive 1999/45/EC
Component Classification Concentration
O-(2-HYDROXYETHYL)-GLYCOLAMIDE
CAS-No. 123-85-3 Xi, R36 <= 100 %
For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

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SECTION 4: First aid measures
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
section 11
Indication of any immediate medical attention and special treatment needed
no data available

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SECTION 5: Firefighting measures
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, nitrogen oxides (NOx)
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

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SECTION 6: Accidental release measures
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure
adequate ventilation. Avoid breathing dust.
For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
Reference to other sections
For disposal see section 13.

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SECTION 7: Handling and storage
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire
protection.
For precautions see section 2.2.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Specific end use(s)
A part from the uses mentioned in section 1.2 no other specific uses are stipulated

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SECTION 8: Exposure controls/personal protection
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested
and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
impervious clothing, The type of protective equipment must be selected according to the
concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher
level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges.
Use respirators and components tested and approved under appropriate government standards
such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Do not let product enter drains.

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SECTION 9: Physical and chemical properties
Information on basic physical and chemical properties
a) Appearance Form: solid
b) Odour no data available
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing Melting point/range: 91 - 93 °C
point
f) Initial boiling point and 338,6 °C at 1.013 hPa
boiling range
g) Flash point no data available
h) Evapouration rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower no data available
flammability or
explosive limits
k) Vapour pressure no data available
l) Vapour density no data available
m) Relative density no data available
n) Water solubility no data available
o) Partition coefficient: n- log Pow: -1,726
octanol/water
p) Auto-ignition no data available
temperature
q) Decomposition no data available
temperature
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
Other safety information
no data available

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SECTION 10: Stability and reactivity
Reactivity
no data available
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available
In the event of fire: see section 5

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SECTION 11: Toxicological information
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitisation
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Additional Information
RTECS: AC3110000
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.

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SECTION 12: Ecological information
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
Other adverse effects
no data available

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SECTION 13: Disposal considerations
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed
professional waste disposal service to dispose of this material. Dissolve or mix the material with a
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.

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SECTION 14: Transport information
UN number
ADR/RID: - IMDG: - IATA: -
UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
Transport hazard class(es)
ADR/RID: - IMDG: - IATA: -
Packaging group
ADR/RID: - IMDG: - IATA: -
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
no data available

---

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SECTION 15 - REGULATORY INFORMATION
N/A

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2(2-羟基乙氧基)乙酰胺 在 吡啶 、 氯化亚砜 作用下， 以 氯仿 、 水 为溶剂， 以91%的产率得到2-(2-氯乙氧基)乙酰胺
  参考文献：
  名称：

  4-Homoisotwistane derivatives

  摘要：

  一种新类的4-同构扭环衍生物的公式，其中R.sub.1是氢原子或C.sub.1-C.sub.3烷基，R.sub.2是烷基，苯基，可以是未取代或取代为C.sub.1-C.sub.3烷基，C.sub.1-C.sub.3烷氧基，硝基或卤原子（以下简称“可选择取代苯基”），公式为--A--OH的基团，其中A是C.sub.1-C.sub.3烷基；公式为--A--B的基团，其中A如上定义，B是卤原子，或公式为##STR2##的基团，其中A如上定义，R.sub.3和R.sub.4独立地是氢原子或C.sub.1-C.sub.3烷基，或R.sub.3和R.sub.4可以与与之连接的相邻氮原子一起形成吡咯烷，哌啶，吗啉，苯酞亚胺或哌嗪，这些衍生物具有强大的抗病毒活性，例如通过将公式为##STR3##的化合物与公式为R.sub.5 OY的化合物反应制备，其中R.sub.1如上定义，X是卤素，R.sub.5具有与R.sub.2相同的含义，除了公式--A--B的基团外，其中A和B如上定义，Y是碱金属。

  公开号：

  US04318925A1
• 作为产物：
  描述：

  1,4-二氧六环-2-酮 在 ammonium hydroxide 作用下， 生成 2(2-羟基乙氧基)乙酰胺
  参考文献：
  名称：

  Kuznetsov,N.V.; Krasavtsev,I.I., Soviet progress in chemistry, 1978, vol. 44, # 7, p. 77 - 80

  摘要：

  DOI：

文献信息

• KUZNETSOV N. V.; KRASAVTSEV I. I., UKR. XIM. ZH., 1978, 44, HO 7, 744-747
  作者：KUZNETSOV N. V.、 KRASAVTSEV I. I.

  DOI：——

  日期：——
• 4-Homoisotwistane derivatives
  申请人：Sumitomo Chemical Co., Ltd.

  公开号：US04318925A1

  公开（公告）日：1982-03-09

  A new class of 4-homoisotwistane derivatives of the formula, ##STR1## wherein R.sub.1 is a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group, and R.sub.2 is an alkyl group, a phenyl group which may be either unsubstituted or substituted with a C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, nitro group or a halogen atom (hereinafter referred to as "an optionally substituted phenyl group"), a group of the formula, --A--OH in which A is a C.sub.1 -C.sub.3 alkylene group; a group of the formula, --A--B in which A is as defined as above and B is a halogen atom, or a group of the formula, ##STR2## in which A is as defined above and R.sub.3 and R.sub.4 are independently a hydrogen atom or a C.sub.1 -C.sub.3 alkyl group or R.sub.3 and R.sub.4 may, when taken together with the adjacent nitrogen atom to which R.sub.3 and R.sub.4 are linked, form pyrrolidine, piperidine, morpholine, phthalimide or piperazine, which have been found to possess potent antiviral activity, are prepared, for example by reacting a compound of the formula, ##STR3## wherein R.sub.1 is as defined above and X is halogen, with a compound of the formula, R.sub.5 OY wherein R.sub.5 has the same meanings as R.sub.2 with the exception of the group of the formula --A--B wherein A and B are as defined above and Y is alkali metal.

  一种新类的4-同构扭环衍生物的公式，其中R.sub.1是氢原子或C.sub.1-C.sub.3烷基，R.sub.2是烷基，苯基，可以是未取代或取代为C.sub.1-C.sub.3烷基，C.sub.1-C.sub.3烷氧基，硝基或卤原子（以下简称“可选择取代苯基”），公式为--A--OH的基团，其中A是C.sub.1-C.sub.3烷基；公式为--A--B的基团，其中A如上定义，B是卤原子，或公式为##STR2##的基团，其中A如上定义，R.sub.3和R.sub.4独立地是氢原子或C.sub.1-C.sub.3烷基，或R.sub.3和R.sub.4可以与与之连接的相邻氮原子一起形成吡咯烷，哌啶，吗啉，苯酞亚胺或哌嗪，这些衍生物具有强大的抗病毒活性，例如通过将公式为##STR3##的化合物与公式为R.sub.5 OY的化合物反应制备，其中R.sub.1如上定义，X是卤素，R.sub.5具有与R.sub.2相同的含义，除了公式--A--B的基团外，其中A和B如上定义，Y是碱金属。
• Kuznetsov,N.V.; Krasavtsev,I.I., Soviet progress in chemistry, 1978, vol. 44, # 7, p. 77 - 80
  作者：Kuznetsov,N.V.、Krasavtsev,I.I.

  DOI：——

  日期：——

表征谱图