2,2'-氧基二(2-丙醇) | 72986-46-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2,2'-氧基二(2-丙醇)
• 中文别名: (4Z)-4-[2-(5-氨基甲酰-2-甲氧苯基)肼亚基]-N-(2-乙氧苯基)-3-羰基-3,4-二氢萘-2-甲酰胺
• 英文名称: 2,2'-Oxydipropan-2-ol
• 英文别名: 2-(2-hydroxypropan-2-yloxy)propan-2-ol
• CAS: 72986-46-0
• 化学式: C₆H₁₄O₃
• 分子量: 134.17
• InChiKey: PRHCBRXAHBBRKA-UHFFFAOYSA-N

物化性质

• 沸点：
  93.0±15.0 °C(Predicted)
• 密度：
  1.039±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• COMPLEXING AGENTS FOR COMPOSITIONS CONTAINING INCLUSION COMPLEXES
  申请人：California Institute of Technology

  公开号：US20170049903A1

  公开（公告）日：2017-02-23

  The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent. According to the method, a therapeutically effective amount of a therapeutic composition of the invention is administered to a mammal (e.g. person or animal) in recognized need of the therapeutic. Also disclosed are compounds having the formula:

  该发明提供了一种含有聚合物和治疗剂的颗粒复合物的组合物。该组合物还包含一种络合剂。聚合物与络合剂在宿主-客体或客体-宿主相互作用中相互作用，形成包含复合物。该发明的治疗组合物可用于传递治疗剂并治疗各种疾病。颗粒复合物的聚合物和络合剂均可用于向治疗组合物引入功能。该发明还涉及一种制备组合物的方法。该方法将治疗剂、具有宿主或客体功能的聚合物以及具有客体或宿主功能的络合剂结合在一起，形成治疗组合物。络合剂与聚合物形成包含复合物。该发明还涉及一种传递治疗剂的方法。根据该方法，在确实需要治疗的已知需要治疗的哺乳动物（例如人或动物）体内给予该发明的治疗组合物的治疗有效量。还披露了具有以下结构的化合物：
• [EN] COMPOSITION AND METHOD FOR PROMOTING HAIR GROWTH<br/>[FR] COMPOSITION ET METHODE POUR FAVORISER LA CROISSANCE CAPILLAIRE
  申请人：SUCAMPO AG

  公开号：WO2005013928A1

  公开（公告）日：2005-02-17

  The present invention provides a method and composition for promoting hair growth in a mammal which comprises a prostaglandin compound having two hetero atoms at the 15 position as an active ingredient thereof.

  本发明提供了一种促进哺乳动物头发生长的方法和组合物，其包括一种在15位置具有两个杂原子的前列腺素化合物作为活性成分。
• Method for treating central nervous system disorders
  申请人：Ueno Ryuji

  公开号：US20060194880A1

  公开（公告）日：2006-08-31

  The present invention provides a method for treating a central nervous system disorder in a mammalian subject, which comprises administering an effective amount of a 11-deoxy-prostaglandin compound to a subject in need thereof. The invention also provide novel 11-deoxy-prostaglandin compound.

  本发明提供了一种治疗哺乳动物主体中枢神经系统障碍的方法，包括向需要治疗的主体投予有效量的11-去氧前列腺素化合物。本发明还提供了新的11-去氧前列腺素化合物。
• Method for treating peripheral vascular diseases
  申请人：Ueno Ryuji

  公开号：US20060247317A1

  公开（公告）日：2006-11-02

  The present invention provides a method for treating peripheral vascular diseases in a mammalian subject, which comprises administering to the patient in need thereof an effective amount of 11-deoxy-prostaglandin compound.

  本发明提供了一种治疗哺乳动物主体的外周血管疾病的方法，包括向需要的患者施用有效量的11-去氧前列腺素化合物。
• LINEAR CYCLODEXTRIN COPOLYMERS
  申请人：California Institute of Technology

  公开号：US20180030207A1

  公开（公告）日：2018-02-01

  Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described. Methods of preparing such copolymers are also described. The linear cyclodextrin copolymer and linear oxidized cyclodextrin copolymer of the invention may be used as a delivery vehicle of various therapeutic agents.

  本发明涉及线性环糊精共聚物和线性氧化环糊精共聚物，其中包含未氧化和/或氧化的环糊精基团集成到聚合物骨架中。本发明还描述了制备这种共聚物的方法。本发明的线性环糊精共聚物和线性氧化环糊精共聚物可用作各种治疗剂的输送载体。