2,3,3-三甲基戊-4-烯酸 | 61740-75-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 2,3,3-三甲基戊-4-烯酸
• 英文名称: 2,3,3-trimethyl-pent-4-enoic acid
• 英文别名: 2,3,3-trimethylpent-4-enoic acid；2,3,3-Trimethyl-4-pentensaeure；4-Pentenoic acid, 2,3,3-trimethyl-
• CAS: 61740-75-8
• 化学式: C₈H₁₄O₂
• mdl: MFCD19228776
• 分子量: 142.198
• InChiKey: QRSJWGNRSRRNEC-UHFFFAOYSA-N

物化性质

• 沸点：
  75-78 °C(Press: 20 Torr)
• 密度：
  0.943±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.625
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,3,3-三甲基戊-4-烯酸 在 lithium aluminium tetrahydride 作用下， 生成 trimethyl-2,3,3 penten-4 ol-1
  参考文献：
  名称：

  Substituent rearrangement and elimination during noncatalyzed Fischer indole synthesis

  摘要：

  DOI：

  10.1021/jo00431a012
• 作为产物：
  描述：

  ethyl 2,3,3-trimethylpent-4-enoate 以77%的产率得到
  参考文献：
  名称：

  GUENTHER, H. J.;GUNTRUM, E.;JAEGER, V., LIEBIGS ANN. CHEM., 1984, N 1, 15-30

  摘要：

  DOI：

文献信息

• Substituted inmidazoles as bombesin receptor subtype-3 modulators
  申请人：Chen David

  公开号：US20100022598A1

  公开（公告）日：2010-01-28

  Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes.

  某些新型取代咪唑是人类炸弹素受体的配体，特别是人类炸弹素受体亚型-3（BRS-3）的选择性配体。因此，它们对于治疗、控制或预防对BRS-3调节敏感的疾病和紊乱，如肥胖症和糖尿病，具有用处。
• Synthesis of Difluoromethylene-Containing 1,2,4-Oxadiazole Compounds via the Reaction of 5-(Difluoroiodomethyl)-3-phenyl-1,2,4-oxadiazole with Unsaturated Compounds Initiated by Sodium Dithionite
  作者：Fanhong Wu、Xueyan Yang、Zhonghua Wang、Xiang Fang、Xianjin Yang、Yongjia Shen

  DOI：10.1055/s-2007-983705

  日期：2007.6

  5-(Difluoroiodomethyl)-3-phenyl-1,2,4-oxadiazole, syn­thesized by the iodination of the corresponding zinc reagent of 5-(bromodifluoromethyl)-3-phenyl-1,2,4-oxadiazole, reacted with various unsaturated compounds, such as alkenes, alkynes, pent-4-en-1-ols, and pent-4-enoic acids, in the presence of sodium dithionite and sodium hydrogen carbonate in aqueous acetonitrile solution at ambient temperature to afford various difluoromethylenated 1,2,4-oxadiazole-containing compounds, including γ-butyrolactones and tetrahydrofurans, in moderate yields.

  5-(二氟碘甲基)-3-苯基-1,2,4-恶二唑，由 5-(溴二氟甲基)-3-苯基-1,2,4-恶二唑的相应锌试剂碘化合成，与各种不饱和化合物，如烯、炔、戊-4-烯-1-醇和戊-4-烯酸反应、在二亚硫酸钠和碳酸氢钠的存在下，在乙腈水溶液中于常温下反应，得到各种二氟甲基化的含 1,2,4-恶二唑的化合物，包括δ-丁内酯和四氢呋喃，收率适中。
• POLYMERIZATION OF OLEFINS
  申请人：——

  公开号：US20030212225A1

  公开（公告）日：2003-11-13

  Olefins containing selected functional groups such as silyl, ether and alkenyl, and often containing a blocking group, may be copolymerized with unsubstituted olefins such as ethylene and propylene in the presence of certain coordination compounds of nickel or palladium. The resulting polymers are useful as molding resins, elastomers, in adhesives and for films.

  含有选择性功能基团（如硅基、醚基和烯基）的烯烃，通常含有阻塞基团，可以与未取代的烯烃（如乙烯和丙烯）在镍或钯的某些配位化合物存在下共聚合。所得的聚合物可用作成型树脂、弹性体、粘合剂和薄膜。
• Substituted imidazoles as bombesin receptor subtype-3 modulators
  申请人：Chen David

  公开号：US20100004280A1

  公开（公告）日：2010-01-07

  Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes.

  某些新型取代咪唑是人类炸弹素受体的配体，特别是人类炸弹素受体亚型-3（BRS-3）的选择性配体。它们因此可用于治疗、控制或预防对BRS-3调节敏感的疾病和障碍，例如肥胖症和糖尿病。
• SUBSTITUTED IMIDAZOLES AS BOMBESIN RECEPTOR SUBTYPE-3 MODULATORS
  申请人：Chen David

  公开号：US20120088788A1

  公开（公告）日：2012-04-12

  Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes.

  某些新型取代咪唑是人类炸弹素受体的配体，特别是人类炸弹素受体亚型3（BRS-3）的选择性配体。因此，它们可用于治疗、控制或预防对BRS-3调节敏感的疾病和障碍，例如肥胖症和糖尿病。