2,3-二氢-3-羟基-2-亚胺-6-苯氧基嘧啶-4-胺 | 84370-86-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2,3-二氢-3-羟基-2-亚胺-6-苯氧基嘧啶-4-胺
• 英文名称: 2,3-Dihydro-3-hydroxy-2-imino-6-phenoxypyrimidin-4-amine
• 英文别名: 3-hydroxy-2-imino-6-phenoxypyrimidin-4-amine
• CAS: 84370-86-5
• 化学式: C₁₀H₁₀N₄O₂
• 分子量: 218.21
• InChiKey: GNQSEISTGYFZSL-UHFFFAOYSA-N

物化性质

• 沸点：
  359.2±45.0 °C(Predicted)
• 密度：
  1.46±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  94.9
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• CONJUGATE OF MINOXIDIL AND PEPTIDE
  申请人：CAREGEN CO., LTD.

  公开号：US20190192677A1

  公开（公告）日：2019-06-27

  The present invention relates to a composition for preventing hair loss and, more specifically, to a compound having a structure in which Minoxidil and a peptide are chemically connected, and to a pharmaceutical composition or cosmetic composition for preventing hair loss or promoting hair growth comprising the compound. The compound having a structure in which Minoxidil and a peptide are chemically connected according to the present invention has not only excellent physiological activity such as hair loss reduction, hair growth promotion or cell growth promotion, but also excellent stability in water, and can therefore be useful as a composition for preventing hair loss and promoting hair growth.

  本发明涉及一种用于预防脱发的组合物，更具体地说，涉及一种具有米诺地尔和肽化学连接的结构的化合物，以及包括该化合物的用于预防脱发或促进生发的药用组合物或化妆品组合物。根据本发明，具有米诺地尔和肽化学连接结构的化合物不仅具有出色的生理活性，如减少脱发、促进生发或促进细胞生长，而且在水中具有出色的稳定性，因此可以作为一种预防脱发和促进生发的组合物。
• COMPOSITION FOR PROMOTING HAIR GROWTH OR PREVENTING HAIR LOSS
  申请人：NEOPHARM CO., LTD.

  公开号：US20160354293A1

  公开（公告）日：2016-12-08

  The present invention relates to a composition for promoting hair growth, preventing hair loss, or relieving inflammation, and more specifically, to a composition which has excellent stability to the skin, has no side effects, and exhibits excellent effects of hair growth promotion and hair loss prevention by promoting hair growth and delaying hair loss. The composition according to the present invention contains a material belonging to a ceramidase inhibitor, glycol, C1-C5 lower alcohol, and water, and thus the composition is safe, has no side effects, can be continuously used for a long period of time, has an excellent effect of hair growth promotion or hair loss prevention by significantly promoting hair growth, and exhibits an inflammation relieving effect as well as a hair growth promoting effect, additionally.

  本发明涉及一种促进头发生长、预防脱发或缓解炎症的组合物，更具体地说，涉及一种对皮肤具有优异稳定性、无副作用，并通过促进头发生长和延缓脱发而展现出优异的促进头发生长和预防脱发的效果的组合物。根据本发明的组合物含有属于酯酶抑制剂、甘醇、C1-C5低级醇和水的材料，因此该组合物安全、无副作用，可长期连续使用，通过显著促进头发生长，具有出色的促进头发生长或预防脱发的效果，并表现出缓解炎症以及促进头发生长的效果。
• Improved penetrating topical pharmaceutical compositions
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0249397A2

  公开（公告）日：1987-12-16

  Topical pharmaceutical compositions containing a specific 6-amino-1,2-dihydro-1-hydroxy-2-iminopyrimidine component and a penetration-enhancing vehicle are disclosed. The vehicle comprises a binary combination of a C₃-C₄ diol or C₃-C₆ triol and a specific C₁₆ or C₁₈ alcohol polar lipid compound. The vehicle provides marked transepidermal and percutaneous delivery of the iminopyrimidine compound. These compositions, when applied topically, act to stimulate the growth of mammalian hair on the body.

  本发明公开了含有特定 6-氨基-1,2-二氢-1-羟基-2-亚氨基嘧啶成分和渗透增强载体的外用药物组合物。 载体包括 C₃-C₄ 二醇或 C₃-C₆ 三醇与特定 C₁₆ 或 C₁₈ 醇极性脂质化合物的二元组合。 载体可明显地经表皮和经皮传递亚氨基嘧啶化合物。 这些组合物外用时可刺激哺乳动物身体毛发的生长。
• LACTOBACILLUS CURVATUS WIKIM55 HAVING ACTIVITY OF PROMOTING HAIR GROWTH, AND COMPOSITION CONTAINING SAME.
  申请人：Korea Food Research Institute

  公开号：EP3636744A2

  公开（公告）日：2020-04-15

  The present disclosure relates to novel Lactobacillus curvatus WIKIM55 isolated from kimchi, and a composition containing the same. The Lactobacillus curvatus WIKIM55 according to the present disclosure is a probiotic having activities of promoting hair growth and can be diversely applied for intestinal regulation and promotion of hair growth in humans or animals.

  本公开涉及从泡菜中分离出的新型卷曲乳杆菌 WIKIM55，以及含有该乳杆菌的组合物。根据本公开，卷曲乳杆菌 WIKIM55 是一种益生菌，具有促进毛发生长的活性，可广泛应用于人类或动物的肠道调节和促进毛发生长。
• COMPOSITION FOR PREVENTING HAIR LOSS AND STIMULATING HAIR GROWTH
  申请人：MOTHER"S PHARMACEUTICAL CO.,LTD.

  公开号：EP3760214A1

  公开（公告）日：2021-01-06

  The present disclosure relates to a composition including a Centipeda minima extract and the fraction thereof as an active ingredient. Since the composition of the present disclosure promotes the production and growth of hair, the composition not only presents excellent effects in the prevention, amelioration, and treatment of hair-loss, but may also be used for promoting hair-growth.

  本公开涉及一种以蜈蚣提取物及其馏分为活性成分的组合物。由于本公开的组合物能促进毛发的生成和生长，因此该组合物不仅在预防、改善和治疗脱发方面具有极佳的效果，还可用于促进毛发生长。