2,3-二溴-2-甲基丁烷 | 594-51-4

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机溴化物
• 中文名称: 2,3-二溴-2-甲基丁烷
• 中文别名: 2,3-二溴异戊烷；2-甲基-2,3-二溴丁烷
• 英文名称: 2,3-dibromo-2-methylbutane
• 英文别名: 2,3-dibromo-3-methylbutane；2,3-dibromo-2-methyl-butane；2,3-Dibrom-2-methyl-butan；Trimethylaethylenbromid；Trimethylaethylen-dibromid；2,3-Dibromo-2-methylbutan
• CAS: 594-51-4
• 化学式: C₅H₁₀Br₂
• 分子量: 229.942
• InChiKey: XLTWAJQKAGLQDX-UHFFFAOYSA-N

物化性质

• 熔点：
  14.85°C
• 沸点：
  189°C (estimate)
• 密度：
  1.7099 (estimate)
• 保留指数：
  972

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  2,3-二溴-2-甲基丁烷 在 soda lime 作用下， 生成 天然橡胶
  参考文献：
  名称：

  Aschan, Chemisches Zentralblatt, 1918, vol. 89, # II, p. 939

  摘要：

  DOI：
• 作为产物：
  描述：

  新戊基碘 在 溴 、 Petroleum ether 作用下， 生成 2,3-二溴-2-甲基丁烷
  参考文献：
  名称：

  The Reactions of Alkyl Iodides with Halogens¹

  摘要：

  DOI：

  10.1021/ja01626a029

文献信息

• Pharmacological examination of contractile responses of the guinea-pig isolated ileum produced by μ-opioid receptor antagonists in the presence of, and following exposure to, morphine
  作者：M K Mundey、A Ali、R Mason、V G Wilson

  DOI：10.1038/sj.bjp.0703659

  日期：2000.11

  We have assessed the potential of several μ‐opioid receptor antagonists to elicit a response in the guinea‐pig isolated ileum in the presence of, and following overnight exposure to, morphine. Naloxone, D‐Phe‐Cys‐Tyr‐D‐Trp‐Orn‐Thr‐Pen‐Thr‐NH2 (CTOP), (−)‐5,9α‐diethyl‐2‐(3‐furyl‐methyl)‐2′‐hydroxy‐6,7‐benzomorphan (MR2266), but not D‐Phe‐Cys‐Tyr‐D‐Trp‐Arg‐Thr‐Pen‐Thr‐NH2 (CTAP), produced a transient inhibition of electrically‐evoked contractions of the guinea‐pig ileum. The effect of 1 μM CTOP, but not that to MR2266, was inhibited by 1 μM somatostatin. Naloxone (0.3 μM), CTOP (3 μM), CTAP (3 μM) and MR2266 (0.3 μM) antagonized the inhibitory effect of morphine on electrically‐evoked contractions of the guinea‐pig to a similar degree and, following 60 min exposure to morphine, produced non‐sustained contractions. The response to 3 μM CTOP was significantly smaller than that to 3 μM CTAP. None of the antagonists produced a response in the absence of morphine. Following overnight exposure of the ileum to 0.3 μM morphine (4°C), and repeated washing to remove the agonist, all four antagonists elicited non‐sustained contractions. However, the responses to 3 μM CTOP and 0.3 μM MR2266 were significantly smaller than those elicited by 0.3 μM naloxone and 3 μM CTAP. Somatostatin (1 μM) significantly reduced naloxone‐induced contractions, but not those to CTAP. While all four μ‐opioid antagonists elicited contractions in the presence of, and following prolonged exposure to, morphine, differences between them were noted which may be a consequence of non‐opioid actions. British Journal of Pharmacology (2000) 131, 893–902; doi:10.1038/sj.bjp.0703659

  我们评估了多种μ‐阿片受体拮抗剂在 Guinea 猪离体回肠中诱发反应的潜力，这些测试是在有吗啡存在的情况下，以及在经过一夜吗啡预处理后进行的。 纳洛酮、CTOP、MR2266，但不包括 CTAP，在 Guinea 猪回肠中诱发了短暂的电刺激收缩抑制。1 μM CTOP 的作用被 1 μM 生长抑素抑制，而 MR2266 的作用未受抑制。 纳洛酮（0.3 μM）、CTOP（3 μM）、CTAP（3 μM）和 MR2266（0.3 μM）均以类似程度拮抗了吗啡对 Guinea 猪回肠电刺激收缩的抑制作用。经过 60 分钟吗啡处理后，拮抗剂诱发了非持续性收缩。在同样的浓度下，CTOP 诱发的反应明显小于 CTAP。在没有吗啡的情况下，所有拮抗剂均未诱发反应。 经过一夜的 0.3 μM 吗啡预处理（4°C），并经过多次清洗以去除激动剂后，四种拮抗剂均诱发了非持续性收缩。然而，3 μM CTOP 和 0.3 μM MR2266 诱发的反应显著小于 0.3 μM 纳洛酮和 3 μM CTAP 诱发的反应。生长抑素（1 μM）显著抑制了纳洛酮诱发的收缩，但未抑制 CTAP 诱发的收缩。 虽然所有四种 μ-阿片受体拮抗剂均可在吗啡存在下以及长期吗啡处理后诱发收缩，但它们之间存在差异，这可能是由于非阿片作用所致。 《英国药理学杂志》（2000 年）第 131 卷，893–902 页；DOI：10.1038/sj.bjp.0703659
• Bromochlorination of Alkenes with Dichlorobromate (1−) Ion. IV. Regiochemistry of Bromochlorinations of Alkenes with Molecular Bromine Chloride and Dichlorobromate (1−) Ion
  作者：Takeshi Negoro、Yoshitsugu Ikeda

  DOI：10.1246/bcsj.59.2547

  日期：1986.8

  The regioselectivity of the addition of molecular bromine chloride to alkenes is dependent on both the steric and electronic effects of the alkyl substituent. In contrast, the regioselectivity of the addition of dichlorobromate (1−) ion to alkenes is controlled mainly by the steric effect of the substituent.

  将氯化溴分子加成到烯烃上的区域选择性取决于烷基取代基的空间和电子效应。相比之下，二氯溴酸盐 (1-) 离子加成到烯烃上的区域选择性主要受取代基的空间效应控制。
• Nuclear magnetic resonance spectroscopy. Barriers to internal rotation in some halogenated methylbutanes
  作者：John D. Roberts、Bruce L. Hawkins、Wolfgang Bremser、S. Borcic

  DOI：10.1021/ja00747a022

  日期：1971.9

  Barriers to internal rotation about the C(2)-C(3) bonds have been determined for ten closely related halogenated methylbutanes by detailed line-shape analysis of their nuclear magnetic resonance spectra. The experimental barriers range from 9 to 16 kcal/mol. In addition, for some of the compounds investigated, free energy differences were obtained for rotational isomers under conditions of slow conformational

  十种密切相关的卤代甲基丁烷通过对其核磁共振谱的详细线形分析确定了 C(2)-C(3) 键内部旋转的障碍。实验屏障范围为 9 至 16 kcal/mol。此外，对于一些研究的化合物，在缓慢的构象交换条件下获得了旋转异构体的自由能差异。结果根据可能的非键相互作用进行讨论。
• Bicyclic-aromatic compounds
  申请人：Centre International de Recherches Dermatologiques Galderma

  公开号：US06147255A1

  公开（公告）日：2000-11-14

  The invention relates to novel bicyclic aromatic compounds which have the general formula (I): ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, respiratory, cardiovascular and ophthalmological complaints in particular), or alternatively in cosmetic compositions.

  该发明涉及具有一般式(I)的新型双环芳香化合物：##STR1## 以及这些化合物在制备用于人类或兽医药物（特别是皮肤科、风湿科、呼吸科、心血管科和眼科疾病）的药物组合物中的用途，或者在化妆品组合物中的用途。
• The nucleophilic contribution of the solvent in olefin bromination. I. Steric inhibition to nucleophilic solvation in alkene bromination via brominium ions
  作者：Marie Francoise Ruasse、Ben Li Zhang

  DOI：10.1021/jo00191a031

  日期：1984.8