2,4-二甲基-2-(羟基甲基)戊二醛 | 63951-48-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2,4-二甲基-2-(羟基甲基)戊二醛
• 英文名称: Pentanedial, 2-(hydroxymethyl)-2,4-dimethyl-
• 英文别名: 2-methoxy-2,4-dimethylpentanedial
• CAS: 63951-48-4
• 化学式: C₈H₁₄O₃
• 分子量: 158.19
• InChiKey: CKURPKAGDUSTMO-UHFFFAOYSA-N

物化性质

• 沸点：
  223.28°C (rough estimate)
• 密度：
  1.0543 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Stabilization of functional proteins
  申请人：Modrovich, Ivan E.

  公开号：EP0562624A2

  公开（公告）日：1993-09-29

  Labile analytes are stabilized by reaction with a biostabilizer in the presence of a condensing or linking agent.

  在冷凝剂或连接剂存在的情况下，易变分析物通过与生物稳定剂反应而得到稳定。
• COVALENTLY-LINKED COMPLEXES OF HIV TAT AND ENV PROTEINS
  申请人：Novartis Ag

  公开号：EP2001508A2

  公开（公告）日：2008-12-17
• HIV ENV PROTEINS WITH MODIFICATIONS IN THE V3 LOOP
  申请人：Novartis AG

  公开号：EP2192918A1

  公开（公告）日：2010-06-09
• Covalently-linked complexes of HIV Tat and Env proteins
  申请人：Sharma Victoria

  公开号：US20080300385A1

  公开（公告）日：2008-12-04

  Complexes of HIV Env and Tat proteins are advantageous as immunogens compared to Tat or Env alone, but they may dissociate when combined with a vaccine adjuvant. To avoid dissociation, complexes of Env and Tat are stabilized by the use of covalent cross linking. The extent of cross linking is important to the binding properties of the complexes, and so is controlled to avoid the loss of Env's ability to bind specifically to CD4 and Tat's ability to bind specifically to anti-Tat monoclonal antibodies.
• Covalently linked complexes of HIV TAT and ENV PROTEINS
  申请人：Barnett Susan W.

  公开号：US20110257377A1

  公开（公告）日：2011-10-20

  Complexes of HIV Env and Tat proteins are advantageous as immunogens compared to Tat or Env alone, but they may dissociate when combined with a vaccine adjuvant. To avoid dissociation, complexes of Env and Tat are stabilized by the use of covalent cross linking. The extent of cross linking is important to the binding properties of the complexes, and so is controlled to avoid the loss of Env's ability to bind specifically to CD4 and Tat's ability to bind specifically to anti-Tat monoclonal antibodies.