2,6-二乙基-4-吡啶胺 | 144291-54-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2,6-二乙基-4-吡啶胺
• 英文名称: 4-amino-2,6-diethylpyridine
• 英文别名: 2,6-diethylpyridin-4-amine
• CAS: 144291-54-3
• 化学式: C₉H₁₄N₂
• 分子量: 150.224
• InChiKey: SVXHCEPTSILAHL-UHFFFAOYSA-N

物化性质

• 沸点：
  269.6±35.0 °C(Predicted)
• 密度：
  0.997±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,6-二乙基-4-吡啶胺 在 碘 、 [双(三氟乙酰氧基)碘]苯 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 以54 %的产率得到4-amino-2,6-diethyl-3-iodopyridine
  参考文献：
  名称：

  [EN] DUAL-ACTING ANGIOTENSIN AND ENDOTHELIN RECEPTOR ANTAGONISTS
  [FR] ANTAGONISTES DU RÉCEPTEUR DE L'ENDOTHÉLINE ET DE L'ANGIOTENSINE À DOUBLE ACTION

  摘要：

  The present disclosure relates generally to dual-acting angiotensin and endothelin receptor antagonists, or pharmaceutically acceptable salts, isotopically enriched analogs, stereoisomers, mixtures of stereoisomers, or prodrugs thereof, and methods of making and using the same.

  公开号：

  WO2023224963A1
• 作为产物：
  描述：

  2,6-二乙基吡喃-4-酮 在 ammonium hydroxide 、 硫酸 、 水 作用下， 以 乙腈 为溶剂， 反应 2.5h， 生成 2,6-二乙基-4-吡啶胺
  参考文献：
  名称：

  A Convenient, One-Stage Transformation of 2,6-Diethyl-4(H)-pyranone to 4-Amino-2,6-diethylpyridine

  摘要：

  The development of the title process and its application on a large scale is described.

  DOI：

  10.1080/00397919408010173

文献信息

• 1,6-naphthyridone derivatives having angiotensin II antagonist activity
  申请人：Imperial Chemical Industries PLC

  公开号：US05217976A1

  公开（公告）日：1993-06-08

  The invention concerns pharmaceutically useful compounds of the formula I, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, Ra, Rb, A, X and Z have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.

  这项发明涉及公式I中的药用化合物，其中R.sup.1、R.sup.2、R.sup.3、R.sup.4、Ra、Rb、A、X和Z具有本文中定义的各种含义，以及它们的无毒盐和含有它们的药物组合物。这些新化合物在治疗高血压和充血性心力衰竭等疾病方面具有价值。该发明还涉及新化合物的制造工艺以及这些化合物在医疗治疗中的应用。
• Pyridinyl compounds which are useful as angiotensin II antagonists
  申请人：Imperial Chemical Industries PLC

  公开号：US05236937A1

  公开（公告）日：1993-08-17

  The invention concerns pharmaceutically useful compounds of the formula I, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, Rz, X and Z have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment. ##STR1##

  这项发明涉及公式I中的药用化合物，其中R.sup.1、R.sup.2、R.sup.3、R.sup.4、R.sup.5、R.sup.6、R.sup.7、Rz、X和Z具有本文所定义的各种含义，以及它们的无毒盐和含有它们的药物组合物。这些新型化合物对治疗高血压和充血性心力衰竭等疾病具有价值。该发明还涉及新型化合物的制备过程以及化合物在医学治疗中的应用。
• Substituted benzoxazole, benzthiazole, and benzimidazole derivatives as
  申请人：Imperial Chemical Industries PLC

  公开号：US05387592A1

  公开（公告）日：1995-02-07

  The invention concerns pharmaceutically useful compounds of the formula I, in which Q, X, Z and Ra have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them for treating conditions as hypertension and congestive heart failure.

  本发明涉及公式I中的具有药用价值的化合物，其中Q，X，Z和Ra具有所述定义的各种含义，以及它们的非毒性盐和含有它们的药物组合物，用于治疗高血压和充血性心力衰竭等疾病。
• Fused pyridine derivatives useful as angiotensin II antagonists
  申请人：Imperial Chemical Industries PLC

  公开号：US05373015A1

  公开（公告）日：1994-12-13

  The invention concerns pharmaceutically useful compounds of the formula I, in which Q, X, Z, G.sup.1, G.sup.2, G.sup.3 and G.sup.4 have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure.

  该发明涉及公式I的药物有用化合物，其中Q、X、Z、G.sup.1、G.sup.2、G.sup.3和G.sup.4具有本文所定义的各种含义，以及它们的非毒性盐和含有它们的药物组合物。这些新型化合物在治疗高血压和充血性心力衰竭等疾病方面具有价值。
• Heterocyclic compounds
  申请人：Imperial Chemical Industries PLC

  公开号：US05281613A1

  公开（公告）日：1994-01-25

  The invention concerns pharmaceutically useful compounds of the formula I, in which Q, X, G.sup.1, Z and Ra have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.

  本发明涉及公式I的药用化合物，其中Q，X，G.sup.1，Z和Ra具有本文中定义的各种含义，以及它们的非毒性盐和包含它们的药物组合物。这些新型化合物在治疗高血压和充血性心力衰竭等疾病方面具有价值。本发明还涉及制造新型化合物的过程以及化合物在医疗治疗中的使用。