2-(1,3-二甲基-2,6-二氧-1,2,3,6-四氢-7H-嘌呤-7-基)-N-[4-(1-甲基丙基)苯基]乙酰胺 | 332117-28-9

• 物质功能分类: 生物化工 - 生化试剂 - 激动剂抑制剂
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 中文名称: 2-(1,3-二甲基-2,6-二氧-1,2,3,6-四氢-7H-嘌呤-7-基)-N-[4-(1-甲基丙基)苯基]乙酰胺
• 中文别名: TCS5861528抑制剂；1,2,3,6-四氢-1,3-二甲基-N-[4-(1-甲基丙基)苯基]-2,6-二氧代-7H-嘌呤-7-乙酰胺
• 英文名称: Chembridge-5861528
• 英文别名: N-(4-butan-2-ylphenyl)-2-(1,3-dimethyl-2,6-dioxopurin-7-yl)acetamide
• CAS: 332117-28-9
• 化学式: C₁₉H₂₃N₅O₃
• 分子量: 369.4
• InChiKey: ZUTUWJYMCADJHD-UHFFFAOYSA-N

物化性质

• 密度：
  1.30±0.1 g/cm3(Predicted)
• 溶解度：
  DMSO：74 mg/mL（200.31 mM；需要超声波和加热）

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  87.5
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

文献信息

• Methods and compositions for treating pain
  申请人：Moran M. Magdalene

  公开号：US20070219222A1

  公开（公告）日：2007-09-20

  The present application relates to compounds and methods for treating pain, incontinence and other conditions.

  本申请涉及化合物和治疗疼痛、失禁和其他疾病的方法。
• METHODS AND COMPOSITIONS FOR TREATING PAIN
  申请人：MORAN MAGDALENE M.

  公开号：US20100267750A1

  公开（公告）日：2010-10-21

  The present application relates to compounds and methods for treating pain, incontinence and other conditions.

  本申请涉及化合物和治疗疼痛、失禁和其他疾病的方法。
• Spider venom peptides and methods of use for modulating sodium channels
  申请人：THE UNIVERSITY OF QUEENSLAND

  公开号：US10662229B2

  公开（公告）日：2020-05-26

  This invention relates to peptides and their use for modulating sodium channels. More particularly, the present invention relates to peptides from the venom of the tarantula Pamphobeteus nigricolor and their use in methods of inhibiting Nav1.7 and for treating or preventing conditions associated with Nav1.7 activity such as neuropathic, inflammatory and nociceptive pain.

  本发明涉及肽及其用于调节钠通道的用途。更具体地说，本发明涉及从狼蛛 Pamphobeteus nigricolor 的毒液中提取的肽及其在抑制 Nav1.7 的方法中的用途，以及在治疗或预防与 Nav1.7 活性相关的疾病（如神经性、炎症性和痛觉性疼痛）中的用途。
• SPIDER VENOM PEPTIDES AND METHODS OF USE FOR MODULATING SODIUM CHANNELS.
  申请人：The University of Queensland

  公开号：EP3472192A1

  公开（公告）日：2019-04-24
• METHODS OF INSECT CONTROL
  申请人：Garrity Paul

  公开号：US20110151018A1

  公开（公告）日：2011-06-23

  The present invention is directed towards methods of inhibiting thermo- and chemo-sensing in insects and pests by inhibiting TRPA1 ion gated channel or family members. The present invention is also directed towards methods of insect control by modulating the TRPA1 ion gated channel or family members. The methods are applicable to a wide variety of insects and pests including agricultural and horticultural pests.