2-[5-(2-methoxyphenoxy)-2-morpholin-4-yl-6-[[(E)-2-phenylethenyl]sulfonylamino]pyrimidin-4-yl]oxyethyl N-pyridin-2-ylcarbamate

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[5-(2-methoxyphenoxy)-2-morpholin-4-yl-6-[[(E)-2-phenylethenyl]sulfonylamino]pyrimidin-4-yl]oxyethyl N-pyridin-2-ylcarbamate
• 化学式: C₃₁H₃₂N₆O₈S
• 分子量: 648.7
• InChiKey: HREHOYSFDWWVER-HYARGMPZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  46
• 可旋转键数：
  14
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  172
• 氢给体数：
  2
• 氢受体数：
  13

文献信息

• [EN] NOVEL SULFONYLAMINO-PYRIMIDINES<br/>[FR] NOUVELLES SULFONYLAMINO-PYRIMIDINES
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2002083650A1

  公开（公告）日：2002-10-24

  The invention relates to novel sulfonylamino-pyrimidines and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as endothelin receptor antagonists.