2-(3-ethoxypyridin-2-ylmethoxy)-3,7-bis(2-fluorophenyl)pyrazolo[1,5-d][1,2,4]triazine | 265643-37-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(3-ethoxypyridin-2-ylmethoxy)-3,7-bis(2-fluorophenyl)pyrazolo[1,5-d][1,2,4]triazine
• 英文别名: 2-[(3-Ethoxypyridin-2-yl)methoxy]-3,7-bis(2-fluorophenyl)pyrazolo[1,5-d][1,2,4]triazine
• CAS: 265643-37-6
• 化学式: C₂₅H₁₉F₂N₅O₂
• 分子量: 459.455
• InChiKey: HDSKRTBTTGXKAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  74.4
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• PYRAZOLO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS
  申请人：Merck Sharp & Dohme Limited

  公开号：EP1121361A1

  公开（公告）日：2001-08-08
• IMIDAZO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS
  申请人：MERCK SHARP & DOHME LTD.

  公开号：EP1409488A1

  公开（公告）日：2004-04-21
• US6476030B1
  申请人：——

  公开号：US6476030B1

  公开（公告）日：2002-11-05
• [EN] PYRAZOLO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS<br/>[FR] DERIVES PYRAZOLO-TRIAZINE UTILISES EN TANT QUE LIGANDS DES RECEPTEURS GABA
  申请人：MERCK SHARP & DOHME

  公开号：WO2000023449A1

  公开（公告）日：2000-04-27

  A class of substituted pyrazolo[1,5-d][1,2,4]triazine derivatives, possessing an optionally substituted cycloalkyl, phenyl or heteroaryl substituent at the 7-position and a substituted alkoxy moiety at the 2-position, are selective ligands for GABAA receptors, in particular having high affinity for the α2 and/or α3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.
• [EN] IMIDAZO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS<br/>[FR] DERIVES D'IMIDAZO-TRIAZINE UTILES COMME LIGANDS POUR LES RECEPTEURS GABA
  申请人：MERCK SHARP & DOHME

  公开号：WO2003008418A1

  公开（公告）日：2003-01-30

  A class of 7-phenylimidazo[1,2-b][1,2,4]triazine derivatives, substituted at the meta position of the phenyl ring by a (cyano)(fluoro)phenyl moiety, being selective ligands for GABAA receptors, in particular having good affinity for the α2 and/or α3 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety and convulsions.