2-Cyclopentyl-7,7-dimethyl-4-(3-thienyl)-3-(4-trifluoromethylbenzoyl)-5,6,7,8-tetrahydro-quinolin-5-one | 221191-63-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Cyclopentyl-7,7-dimethyl-4-(3-thienyl)-3-(4-trifluoromethylbenzoyl)-5,6,7,8-tetrahydro-quinolin-5-one
• 英文别名: 2-Cyclopentyl-7,7-dimethyl-4-(thien-3-yl)-3-(4-trifluoromethylbenzoyl)-5,6,7,8-tetrahydro-quinolin-5-one；2-Cyclopentyl-7,7-dimethyl-4-thiophen-3-yl-3-[4-(trifluoromethyl)benzoyl]-6,8-dihydroquinolin-5-one
• CAS: 221191-63-5
• 化学式: C₂₈H₂₆F₃NO₂S
• 分子量: 497.581
• InChiKey: PMBDQVVHJJWYLO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  35
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  75.3
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• Hetero-tetrahydroquinolines
  申请人：——

  公开号：US20020062024A1

  公开（公告）日：2002-05-23

  Hetero-tetrahydroquinolines can be prepared either by condensing correspondingly substituted hetero-tetrahydroquinoline aldehydes with the desired substituent or by reducing the corresponding keto-substituted hetero-tetrahydroquinolines, followed by introduction of the desired substituent by customary methods. The hetero-tetrahydroquinolines are suitable for use as active compounds in medicaments, in particular in medicaments for treating artheriosclerosis and dyslipidaemias.

  杂-四氢喹啉的制备方法可以是将相应取代的杂-四氢喹啉醛与所需的取代基缩合，也可以是还原相应的酮取代的杂-四氢喹啉，然后通过常规方法引入所需的取代基。杂四氢喹啉适合用作药物中的活性化合物，特别是治疗动脉硬化和血脂异常的药物。
• [DE] 4-HETEROARYL-TETRAHYDROCHINOLINE UND IHRE VERWENDUNG ALS INHIBITOREN DES CHOLESTERIN-ESTER-TRANSFER-PROTEINS (CTEP)<br/>[EN] 4-HETEROARYL-TETRAHYDROQUINOLINES AND THEIR USE AS INHIBITORS OF THE CHOLESTERIN-ESTER TRANSFER PROTEIN<br/>[FR] 4-HETEROARYLE-TETRAHYDROQUINOLEINES ET LEUR UTILISATION COMME INHIBITEURS DE LA PROTEINE DE TRANSFERT CHOLESTERINE-ESTER
  申请人：BAYER AKTIENGESELLSCHAFT

  公开号：WO1999014215A1

  公开（公告）日：1999-03-25

  (DE) Hetero-Tetrahydrochinoline können hergestellt werden, indem man entweder entsprechend substituierte Hetero-Tetrahydrochinolin-Aldehyde mit dem gewünschten Substituenten kondensiert oder die entsprechenden Keto-substituierten Hetero-Tetrahydrochinoline reduziert und anschließend den gewünschten Substituenten nach üblichen Methoden einführt. Die Hetero-Tetrahydrochinoline eignen sich als Wirkstoffe in Arzneimittel, insbesondere in Arzneimitteln zur Behandlung von Artheriosklerose und Dyslipidämien.(EN) The invention concerns hetero-tetrahydroquinolines obtained either by corresponding condensation of heterotetrahydroquinolines aldehydes substituted, with the desired substituent, or by reduction of corresponding keto-substituted hetero-tetrahydroquinolines, then by introducing the desired substituents by the usual methods. Said hetero-tetrahydroquinolines are used as active principles, particularly in medicines for treating arterial sclerosis and dyslipemia.(FR) L'invention concerne des hétéro-tétrahydroquinoléines obtenues soit par condensation correspondante d'aldéhydes d'hétéro-tétrahydroquinoléine substitués, avec le substituant voulu, soit par réduction des hétéro-tétrahydroquinoléines substituées par céto, correspondantes, puis introduction des substituants voulus selon des méthodes habituelles. Ces hétéro-tétrahydroquinoléines s'utilisent comme principes actifs dans des médicaments, notamment dans des médicaments destinés au traitement de l'artériosclérose et de dyslipidémies.

  异型四氢青⇄B quake不能人事获取，可以通过相应类型的异型四hydroChinoline醛用正确的取代基方式制备，或者对相应的酮取代异型四氢Chinoline进行还原后，通过常规方法添加所需的取代基。异型四氢青⇄B chloride作为活性成分，尤其是用于治疗动脉硬化的药物和脂蛋白异常。( translate 解释按照中文版本翻译即可，其他版本的翻译暂不详细展示。 )
• 4-HETEROARYL-TETRAHYDROCHINOLINE UND IHRE VERWENDUNG ALS INHIBITOREN DES CHOLESTERIN-ESTER-TRANSFER-PROTEINS (CTEP)
  申请人：Bayer Aktiengesellschaft

  公开号：EP1017692A1

  公开（公告）日：2000-07-12
• 4-heteroaryl-tetrahydroquinolines and their use as inhibitors of the cholesterin-ester transfer protein
  申请人：Stoltefuß Jürgen

  公开号：US20060069112A1

  公开（公告）日：2006-03-30

  Hetero-tetrahydroquinolines can be prepared either by condensing correspondingly substituted hetero-tetrahydroquinoline aldehydes with the desired substituent or by reducing the corresponding keto-substituted hetero-tetrahydroquinolines, followed by introduction of the desired substituent by customary methods. The hetero-tetrahydroquinolines are suitable for use as active compounds in medicaments, in particular in medicaments for treating artheriosclerosis and dyslipidaemias.
• 4-HETEROARYL-TETRAHYDROQUINOLINES AND THEIR USE AS INHIBITORS OF THE CHOLESTERIN-ESTER TRANSFER PROTEIN
  申请人：STOLTEFUSS JURGEN

  公开号：US20070142420A1

  公开（公告）日：2007-06-21

  Hetero-tetrahydroquinolines can be prepared either by condensing correspondingly substituted hetero-tetrahydroquinoline aldehydes with the desired substituent or by reducing the corresponding keto-substituted hetero-tetrahydroquinolines, followed by introduction of the desired substituent by customary methods. The hetero-tetrahydroquinolines are suitable for use as active compounds in medicaments, in particular in medicaments for treating artheriosclerosis and dyslipidaemias.