(2R,3S,4R,5S)-2-(hydroxymethyl)-5-(1H-indol-3-yloxy)oxolane-3,4-diol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3S,4R,5S)-2-(hydroxymethyl)-5-(1H-indol-3-yloxy)oxolane-3,4-diol
• 化学式: C₁₃H₁₅NO₅
• 分子量: 265.26
• InChiKey: KXYDVHGEAGAFNE-FDYHWXHSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  94.9
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Enzyme substrates
  申请人：——

  公开号：US20040259181A1

  公开（公告）日：2004-12-23

  This invention provides new methods for detecting enzyme activity using enzyme substrates comprising an enzyme cleavable portion and a chromogenic portion. The enzyme cleavable portion is a &bgr;-D-ribofuranosyl group and the chromogenic portion forms a detectable indicator following enzyme cleavage. In one aspect of this invention the chromogenic &bgr;-D-ribofuranoside substrate forms a coloured substantially non-diffusable indicator. A second aspect of this invention provides novel chromogenic &bgr;-D-ribofuranosides.

  本发明提供了使用酶底物检测酶活性的新方法，酶底物包括酶可裂解部分和发色部分。酶可裂解部分是一个 &bgr;-D-呋喃核糖基团，发色部分在酶裂解后形成可检测的指示剂。在本发明的一个方面中，发色性 &bgr;-D-ribofuranoside 底物形成一种有色的基本上不可扩散的指示剂。本发明的第二个方面提供了新型的发色性&bgr;-D-呋喃核苷。
• ENZYME SUBSTRATES FOR DETECTING BETA-D-RIBOFURANOSIDASE ACTIVITY
  申请人：Burton, Michael

  公开号：EP1438424B1

  公开（公告）日：2006-01-18
• Enzyme Substrates
  申请人：Burton Michael

  公开号：US20080193959A1

  公开（公告）日：2008-08-14

  This invention provides new methods for detecting enzyme activity using enzyme substrates comprising an enzyme cleavable portion and a chromogenic portion. The enzyme cleavable portion is a β-D-ribofuranosyl group and the chromogenic portion forms a detectable indicator following enzyme cleavage. In one aspect of this invention the chromogenic β-D-ribofuranoside substrate forms a coloured substantially non-diffusable indicator. A second aspect of this invention provides novel chromogenic β-D-ribofuranosides.
• US7384763B2
  申请人：——

  公开号：US7384763B2

  公开（公告）日：2008-06-10
• US7709223B2
  申请人：——

  公开号：US7709223B2

  公开（公告）日：2010-05-04