摩熵化学
数据库官网
小程序
打开微信扫一扫
首页 分子通 化学资讯 化学百科 反应查询 关于我们
请输入关键词

2-(3-乙氧基-4-羟基苯基)-2-羟基乙酸 | 39549-22-9

中文名称
2-(3-乙氧基-4-羟基苯基)-2-羟基乙酸
中文别名
——
英文名称
3-ethoxy-4-hydroxymandelic acid
英文别名
3-ethoxy-4-hydroxy-mandelic acid;4-Hydroxy-3-aethoxy-DL-mandelsaeure;3-Aethoxy-4-hydroxy-mandelsaeure;(3-ethoxy-4-hydroxyphenyl)hydroxy-acetic acid;4-hydroxy-3-ethoxyphenylglycolic acid;3-ethoxy-p-hydroxymandelic acid;2-(3-ethoxy-4-hydroxyphenyl)-2-hydroxyacetic acid
2-(3-乙氧基-4-羟基苯基)-2-羟基乙酸化学式
CAS
39549-22-9
化学式
C10H12O5
mdl
——
分子量
212.202
InChiKey
YOIZTLBZAMFVPK-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    425.2±45.0 °C(Predicted)
  • 密度:
    1.377±0.06 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    0.8
  • 重原子数:
    15
  • 可旋转键数:
    4
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.3
  • 拓扑面积:
    87
  • 氢给体数:
    3
  • 氢受体数:
    5

安全信息

  • 海关编码:
    2918990090

SDS

SDS:dd9160983fc9fcdce0ff8062755e1f85
查看

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量
  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    参考文献:
    名称:
    Design, synthesis, and evaluation of phenylpiperazine-phenylacetate derivatives as rapid recovery hypnotic agents
    摘要:
    DOI:
    10.1016/j.bmcl.2021.128497
  • 作为产物:
    参考文献:
    名称:
    Pharmaceutical compositions of short-acting sedative hypnotic agent
    摘要:
    本发明提供了一种药物组合物,该组合物包括一种苯乙酸酯化合物,用于在哺乳动物中诱导或维持全身麻醉或镇静,以及制备此类组合物的方法和使用此类组合物诱导或维持麻醉或镇静的方法。
    公开号:
    US20050020674A1
点击查看最新优质反应信息

文献信息

  • METHOD FOR PREPARING P-HYDROXYMANDELIC COMPOUNDS IN STIRRED REACTORS
    申请人:Rhodia Operations
    公开号:US20170183283A1
    公开(公告)日:2017-06-29
    The process allows the preparation of a p-hydroxymandelic compound, comprising at least one step of condensation of at least one aromatic compound bearing at least one hydroxyl group and whose para position is free, with glyoxylic acid, the condensation reaction being performed in at least one reactor equipped with at least one mixing means, the specific mixing power being between 0.1 kW/m 3 and 15 kW/m 3 . In addition, the invention also relates to a process for preparing a 4-hydroxyaromatic aldehyde by oxidation of this p-hydroxymandelic compound.
    该过程允许制备一种p-羟基苯乙酸化合物,包括至少一步将至少一种带有至少一个羟基且对位空闲的芳香化合物与乙醛酸进行缩合的步骤,缩合反应在至少一个配备至少一个混合手段的反应器中进行,具体混合功率在0.1 kW/m3和15 kW/m3之间。此外,该发明还涉及通过氧化该p-羟基苯乙酸化合物制备4-羟基芳香醛的过程。
  • Method for separating mandelic compounds in salified form and use of same for preparing aromatic aldehyde
    申请人:RHODIA OPERATIONS
    公开号:US20160318839A1
    公开(公告)日:2016-11-03
    The invention describes a method for separating a mandelic compound in salified form from an aqueous reaction medium resulting from the condensation reaction of a hydroxylated aromatic compound with glyoxylic acid in a basic medium, said method comprising a) decanting said reaction medium in such a way as to recover an organic phase formed from the excess of said aromatic compound and an aqueous phase formed from said mandelic compound and a quantity of the excess of said aromatic compound and b) bringing said aqueous phase into contact with an adsorbent support, resulting in the selective adsorption of said aromatic compound and the recovery of an aqueous flow comprising said mandelic compound in salified form, which is subjected to an oxidation step before being converted into hydroxyaromatic aldehyde by electrodialysis.
    该发明描述了一种从含盐形式的苯甲酸类化合物中分离的方法,该化合物是从在碱性介质中羟基芳香化合物与乙醛酸进行缩合反应所得的水相反应介质中分离出来的。该方法包括a) 将所述反应介质倾析,以便从所述芳香化合物的过量形成的有机相和从所述苯甲酸类化合物及所述芳香化合物的过量量形成的水相中回收;b) 将所述水相与吸附支撑物接触,导致选择性吸附所述芳香化合物并回收含盐形式的所述苯甲酸类化合物的水流,然后在将其转化为羟基芳香醛之前,通过电渗析进行氧化处理。
  • METHOD FOR PREPARING OPTIONALLY SUBSTITUTED P-HYDROXYMANDELIC COMPOUNDS AND DERIVATIVES THEREOF
    申请人:Heinisch Bruno
    公开号:US20110009664A1
    公开(公告)日:2011-01-13
    The invention relates to a method for preparing optionally substituted P-hydroxymandelic compounds and derivatives thereof. The method for preparing the mandelic compounds of the invention comprises condensing in water, in the presence of an alkaline agent, an aromatic compound bearing at least one hydroxyl group and having a free para position, with glycoxylic acid, wherein said method is characterised in that said reaction is carried out in a piston-flow reactor.
    该发明涉及一种制备可选择取代的P-羟基苯乙酸化合物及其衍生物的方法。该发明的制备苯乙酸化合物的方法包括在水中,在碱性剂的存在下,将至少含有一个羟基且具有一个自由对位的芳香化合物与乙醛酸缩合,其中所述方法的特征在于该反应是在活塞流反应器中进行的。
  • 具有提高的药代动力学性能和麻醉性能的苯 基乙酸酯类化合物
    申请人:济南蓝丹医药科技有限公司
    公开号:CN105272871B
    公开(公告)日:2017-08-22
    具有提高的药代动力学性能和麻醉性能的苯基乙酸酯类化合物。本发明提供一种式(I)所示的苯基乙酸酯类化合物。其中R1为L1OC(O)L2,L1为取代或未取代的C1‑C6烷基,L2为取代或未取代的C1‑C6烷基;R2为单卤代,多卤代或者未取代的C1‑C6烷基,C3‑C6环烷基,C2‑C6烯基或炔基;R3、R4各自独立地为(C1‑C6)烷基。本发明化合物具有短效镇静催眠以及麻醉的诱导和维持作用,且具有更短的麻醉后行为恢复时间。
  • Process for preparing mandelic aromatic compounds and aromatic aldehyde compounds
    申请人:RHODIA OPERATIONS
    公开号:US20160297735A1
    公开(公告)日:2016-10-13
    A process for preparing an aromatic compound or compounds where at least one mandelic group —CHOH—COOH is described, comprising a reaction for condensation of at least one aromatic compound with glyoxylic acid or derivatives thereof, wherein said condensation reaction is carried out substantially in the absence of any acid or any base added to the reaction medium. The condensation reaction is followed by an oxidation reaction in order to obtain aromatic aldehyde.
    描述了一种制备芳香化合物的方法,其中至少有一个苯乙酸基团—CHOH—COOH,包括将至少一种芳香化合物与乙二醛酸或其衍生物进行缩合反应的步骤,其中所述缩合反应在基本上不添加任何酸或任何碱到反应介质中进行。缩合反应后进行氧化反应以获得芳香醛。
查看更多